Effect of premature serum progesterone rise on embryo transfer outcomes and the role of blastocyst culture and transfer in assisted reproductive technology cycles with premature progesterone rise

Abstract

PPR did not significantly compromise the clinical outcomes in this series. However, shifting to blastocyst transfer probably could increase the live birth in cycles with PPR.

Area under the curve of temporal estrogen and progesterone measurements during assisted reproductive technology: Which hormone is the main determinant of cycle outcome?

“…20 In our data, there were both cleavage and blastocyst stage embryo transfers, although there are many conflicting results on the impact of embryo stage on implantation in cycles with impaired endometrial receptivity. 21,22 According to our results, clinical pregnancy and implantation rates were similar between groups with the transfer of two different embryo stages. Subgroup analyses showed that only the predictive value of AUCEM remained statistically significant for the cycle outcome in a subgroup of women with blastocyst transfers.…”

“…In our data, there were both cleavage and blastocyst stage embryo transfers, although there are many conflicting results on the impact of embryo stage on implantation in cycles with impaired endometrial receptivity . According to our results, clinical pregnancy and implantation rates were similar between groups with the transfer of two different embryo stages.…”

The impact of progesterone level on day of hCG injection in IVF Cycles on clinical pregnancy rate

“…[ 2 14 ] There was no concomitant rise in LH levels on the day of trigger in association with premature progesterone elevation in our study. In the study by Huang et al .,[ 25 ] the incidence of PPR was 13.02%. The incidence of PPR in the GnRH agonist subgroup (18%) was significantly higher than in the GnRH antagonist subgroup (9.31%).…”

The validity of progesterone level on hCG injection day in the prediction of IVF/ICSI cycles’ outcome

“…The incidence of PER in our study was 55.5% (142/256), based on a cut-off level of 1.5nmol/L for P 4 . This igure is high if compared with igures of 13.19% [19], 13.02% [18] and 38.3% [7]. However, comparison is dif icult when the de inition of PE is different in various studies.…”

“…Lower pregnancy rate and higher pregnancy loss with PE in IVF cycles had been observed in studies conducted by Silverberg, et al [4], although the mechanism of this remains controversial [4,13]. Then, several authors investigated the effect of PE during the IVF cycles with GnRH analogues, some of these reported negative impact on the live birth and pregnancy rate, while others didn't ind any association [14][15][16][17][18]. T he aim of this study was to assess the validity of progesterone level on hCG day (P 4 ) in the prediction of IVF/ ICSI cycles' outcome in a Saudi setting.…”