Effect of pregnancy on insulin metabolism in spontaneously hyperensive rats

Tanigawa, Keiichiro; Miura, Toshihiro; Ishihara, Eriko; Kawaguchi, Mikiko

doi:10.1016/s0026-0495(99)90139-7

Cited by 2 publications

(2 citation statements)

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“…Conversely, we found that in SHR, pregnancy remarkably reduced pressure at delivery, confirming previous data (Zamorano et al 1980, Lindheimer et al 1983, Ahokas & Sibai 1990. The pressure decrease near term was not associated with an alteration of insulin resistance (Tanigawa et al 1999) and could be related to an increase of nitric oxide in pregnancy (Conrad et al 1993), or the release of hypotensive substances by the placenta (Nakanishi et al 1980), or the modification of the reninangiotensin system (Ahokas et al 1989).…”

Section: Discussionsupporting

confidence: 91%

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Maternal adaptations to pregnancy in spontaneously hypertensive rats: leptin and ghrelin evaluation

Raso

Bianco

Iacono

et al. 2007

Journal of Endocrinology

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Leptin and/or ghrelin, initially thought to be considered messengers of energy metabolism, are now considered to play a role in normal and complicated pregnancy. In this study, pregnant, spontaneously hypertensive rats (SHR) have been used to evaluate, for the first time, the modification of leptin and ghrelin both at serum and tissue levels. In SHR, we evaluate plasma leptin level and tissue protein expression in both placenta and adipose tissue at the end of gestation (day 20) versus normotensive Wistar-Kyoto (WKY) animals. The expression of functional leptin receptor (Ob-Rb) in peripheral tissues and in the hypothalamus was evaluated. Moreover, we measured plasma ghrelin level and its mRNA expression in the stomach and placenta. SHR strain presented significantly lower plasma leptin levels when compared with those found in pregnant or not WKY controls. Interestingly, in the placenta, leptin gene expression was higher in SHR than normotensive WKY. Moreover, we demonstrated a resistance to the effects of leptin via 'downregulation' of hypothalamic receptors in pregnant SHR. Conversely, SHR presented significantly higher ghrelin plasma levels when compared with those found in pregnant or not WKY. However, we observed that ghrelin level in the stomach of SHR did not change during pregnancy, and on the opposite, mRNA ghrelin in the placenta of SHR was lower than that of normotensive rats, suggesting a different production of this hormone in the fetal-placental unit. These data gain further insight into metabolic hormone modifications observed in a model of pre-existing hypertension associated with pregnancy.

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Section: Discussionsupporting

confidence: 91%

“…Unlike another study (Tanigawa et al 1999), the normotensive pregnant rats that we examined showed no change in blood pressure during the gestational period. Conversely, we found that in SHR, pregnancy remarkably reduced pressure at delivery, confirming previous data (Zamorano et al 1980, Lindheimer et al 1983, Ahokas & Sibai 1990.…”

Section: Discussioncontrasting

confidence: 61%