Impaired neural regulation of insulin secretion related to the leptin receptor gene mutation in Wistar fatty rats

Ohnuma, Hiroshi; Yamatani, Keiichi; Daimon, Makoto; Inamori, Masahiko; Manaka, Hideo; Sasaki, Hideo; Kato, Takeshi

doi:10.1016/s0031-9384(00)00297-3

Cited by 5 publications

(2 citation statements)

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“…In fact, a common genetic factor in SHR and WKY has already been proposed by others. Interestingly, it has been related to diminished sensitivity to vagal activity [26], which argues in favor of the secondary role of hypertension in the development of insulin resistance in this animal model. However, the lack of definition in genetics [27] between SHR, WKY, and WIS, from which both the previous 2 strains were derived, further disturbs the analysis of this animal model.…”

Section: Insulin Resistance and Hypertensionmentioning

confidence: 79%

Hepatic parasympathetic role in insulin resistance on an animal model of hypertension

2007

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Section: Insulin Resistance and Hypertensionmentioning

confidence: 79%

Hepatic parasympathetic role in insulin resistance on an animal model of hypertension

2007

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“…Leptin deficiency in both mice and humans causes morbid obesity and diabetes, and replacement treatment leads to decreased food intake, normalized glucose homeostasis, and increased energy expenditure [32, 52–55]. Two genetic markers adjacent to human LEP gene have been found to be modestly associated with NTDs possibly via an inherited effect, irrespective of maternal BMI [56].…”

Section: Discussionmentioning

confidence: 99%

Maternal–fetal metabolic gene–gene interactions and risk of neural tube defects

Lupo

Mitchell

Canfield

et al. 2014

Molecular Genetics and Metabolism

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Single-gene analyses indicate that maternal genes associated with metabolic conditions (e.g., obesity) may influence the risk of neural tube defects (NTDs). However, to our knowledge, there have been no assessments of maternal-fetal metabolic gene-gene interactions and NTDs. We investigated 23 single nucleotide polymorphisms among 7 maternal metabolic genes (ADRB3, ENPP1, FTO, LEP, PPARG, PPARGC1A, and TCF7L2) and 2 fetal metabolic genes (SLC2A2 and UCP2). Samples were obtained from 737 NTD case-parent triads included in the National Birth Defects Prevention Study for birth years 1999–2007. We used a 2-step approach to evaluate maternal-fetal gene-gene interactions. First, a case-only approach was applied to screen all potential maternal and fetal interactions (n=76), as this design provides greater power in the assessment of gene-gene interactions compared to other approaches. Specifically, ordinal logistic regression was used to calculate the odds ratio (OR) and 95% confidence interval (CI) for each maternal-fetal gene-gene interaction, assuming a log-additive model of inheritance. Due to the number of comparisons, we calculated a corrected p-value (q-value) using the false discovery rate. Second, we confirmed all statistically significant interactions (q<0.05) using a log-linear approach among case-parent triads. In step 1, there were 5 maternal-fetal gene-gene interactions with q<0.05. The “top hit” was an interaction between maternal ENPP1 rs1044498 and fetal SLC2A2 rs6785233 (interaction OR=3.65, 95% CI: 2.32–5.74, p=2.09×10−8, q=0.001), which was confirmed in step 2 (p=0.00004). Our findings suggest that maternal metabolic genes associated with hyperglycemia and insulin resistance and fetal metabolic genes involved in glucose homeostasis may interact to increase the risk of NTDs.

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A mixture of Salacia reticulata (Kotala himbutu) aqueous extract and cyclodextrin reduces body weight gain, visceral fat accumulation, and total cholesterol and insulin increases in male Wistar fatty rats

et al. 2009

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Impaired neural regulation of insulin secretion related to the leptin receptor gene mutation in Wistar fatty rats

Cited by 5 publications

References 20 publications

Hepatic parasympathetic role in insulin resistance on an animal model of hypertension

Hepatic parasympathetic role in insulin resistance on an animal model of hypertension

Maternal–fetal metabolic gene–gene interactions and risk of neural tube defects

A mixture of Salacia reticulata (Kotala himbutu) aqueous extract and cyclodextrin reduces body weight gain, visceral fat accumulation, and total cholesterol and insulin increases in male Wistar fatty rats

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