Effect of prednisone administration on coagulation variables in healthy<scp>B</scp>eagle dogs

Rose, Lara; Dunn, Marilyn; Allegret, Virginie; Bédard, Christian

doi:10.1111/j.1939-165x.2011.00364.x

Cited by 60 publications

(79 citation statements)

References 33 publications

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“…There were no significant changes in any of the remaining hemostatic indices that were measured during prednisone administration. The results of our study are in contrast to previous studies that have demonstrated changes in multiple indices of hemostasis during prednisone treatment . In one previous study, in contrast to our study, platelet aggregation with ADP as an agonist increased when dogs were administered immunosuppressive dosages of prednisone .…”

Section: Discussioncontrasting

confidence: 99%

“…Unfortunately, a direct comparison between this previous study and our study cannot be made because differences in the aggregometry protocol and ADP concentration used do not provide consistent conditions to allow assessment of the effects of prednisone on platelet aggregation. Previous studies utilizing thromboelastography have suggested that healthy dogs became hypercoagulable while receiving glucocorticoid treatment . Although thromboelastography was not used in our study, a very similar method, viscoelastometry, was used, and no significant differences before and after treatment with prednisone were detected.…”

Section: Discussionmentioning

confidence: 77%

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Effects of immunosuppressive agents on the hemostatic system in normal dogs

Thomason

Archer

Wills

et al. 2018

Veterinary Internal Medicne

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BackgroundIn dogs, the effects of immunosuppressive medications on hemostasis are not well known.Hypothesis/ObjectivesThe objective was to determine the effects of immunosuppressive medications on primary and secondary hemostasis. Our hypothesis was that cyclosporine and prednisone would increase markers of hypercoagulability and thromboxane synthesis, while azathioprine, mycophenolate mofetil, and leflunomide would have minimal effects on hemostasis.AnimalsEight healthy dogs.MethodsA randomized, cross‐over study used aggregometry, the PFA‐100 platelet function analyzer, viscoelastometry, platelet count, and prothrombin and activated partial thromboplastin times to evaluate hemostasis during the administration of prednisone, azathioprine, cyclosporine, mycophenolate mofetil, and leflunomide for 1 week each at standard oral doses. Urine 11‐dehydro‐thromboxane‐B2 (11‐dTXB2) and 6‐keto‐prostaglandin‐F1α (6‐keto‐PGF1α) concentrations, normalized to urine creatinine concentration, were measured.ResultsThe aggregometry amplitude decreased from 51 ± 21 to 27 ± 14 (P = .002) during leflunomide treatment (ADP activation), but there were no differences in amplitude (P = .240) for any medications when platelets were activated with collagen. For all medications, there were no significant differences in viscoelastometry indices (ACT, P = .666; ClotRate, P = .340; and platelet function, P = .411) and platelet count (P = .552). Compared with pretreatment values, urinary 11‐dTXB2‐to‐creatinine ratio increased (P = .001) after drug administration (from 3.7 ± 0.6 to 5.6 ± 1.1). Cyclosporine was associated with an increase (P < .001) in the 6‐keto‐PGF1α‐to‐creatinine ratio (from 10.3 ± 4.6 to 22.1 ± 5.3).Conclusions and Clinical ImportanceMost immunosuppressive drugs do not enhance platelet function or coagulation in healthy dogs, suggesting that these medications might not predispose hypercoagulable dogs to thromboembolism. The results of our study need to be correlated with the clinical outcomes of hypercoagulable dogs.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 77%

Effects of immunosuppressive agents on the hemostatic system in normal dogs

Thomason

Archer

Wills

et al. 2018

Veterinary Internal Medicne

View full text Add to dashboard Cite

show abstract

“…The lack of statistical difference in the parameters between anti-inflammatory and immunosuppressive doses, observed by Rose et al [10] and the present study, suggests that there is no dose-dependent effect of prednisone on the hemostatic system in a two-week protocol.…”

Section: Resultscontrasting

confidence: 57%

“…The correlation between increased platelet count and hypercortisolism is extremely controversial, as most of the studies aimed to demonstrate this correlation have evaluated patients with immune-mediated disorders (e.g., immune-mediated thrombocytopenia), and consequently, an increase of platelet number would be expected after corticotherapy due to a diminution of platelet destruction [10]. …”

Section: Resultsmentioning

confidence: 99%

“…Although it is impossible to determine if prednisone administration is the only cause, it is reasonable to conclude that glucocorticoids may contribute to a hypercoagulable condition [34]. A study made by Rose et al proved the hypercoagulable condition using both anti-inflammatory and immunosuppressive doses in dogs treated for two weeks with prednisone, which was confirmed by thromboelastographic changes [10]. …”

Section: Resultsmentioning

confidence: 99%

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Hemostatic profile and thromboembolic risk in healthy dogs treated with prednisone: a randomized controlled trial

et al. 2013

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BackgroundThrombosis has been associated to some diseases like hyperadrenocorticism (HAC). Several drugs can alter the balance, such as the corticosteroid prednisone, used mainly for its anti-inflammatory and immunosuppressive effects. It is known that hypercortisolism can stimulate thrombi formation by increasing coagulation factors and decreasing fibrinolysis. However it is not known how prednisone administration affects hemostasis in dogs and if it is dose dependent. The aim of this study, therefore, was to demonstrate the effects of prednisone administration on dogs’ hemostatic profile.ResultsSignificant decrease of antithrombin levels was observed in both groups (anti-inflammatory and immunosuppressive doses) after 15 days of treatment. An increase of platelet aggregation was observed in dogs receiving immunosuppressive doses of prednisone (Group II).ConclusionsFrom the results obtained in our study, it is not possible to infer that hypercortisolism can increase the thromboembolic risk, despite the decreased anticoagulant factors (antithrombin levels).

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