Effect of Preconception, Prenatal and Postnatal Exposure to Ambient Air Pollution on Laryngitis in Southern Chinese Children

Abstract

Environmental exposure is considered to be a main triggering factor of laryngitis, a common upper respiratory tract infection, especially in developing countries. However, unclear detrimental air pollutants and lack of understanding on their early-life exposure and laryngitis warrant further investigation. Therefore, a retrospective cohort including 2328 preschool children was conducted during 2015–2016 in Shenzhen, China. We measured ambient air quality of PM10, SO2 and NO2 in 12 monitoring stations, and obtained childhood laryngitis prevalence and confounding covariates by questionnaire. Multiple logistic regression analysis showed that the lifetime prevalence of childhood laryngitis (12.2%) was associated with an interquartile range increase in late preconception (adjusted odds ratio: 1.43, 95% confidence interval: 1.06‒1.92), prenatal (1.35, 1.02–1.79) and early-postnatal (1.32, 1.11‒1.57) exposure to SO2. Sensitivity analysis revealed that this relationship appeared more obvious among boys without parental atopy, mold/damp stains, or window condensation. Nevertheless, there was no evidence for the association between early-life PM10 and NO2 exposure and childhood laryngitis. These findings suggest that early-life exposure to SO2 significantly increases risk of childhood laryngitis. Preventive measures need to be implemented to mitigate industrial air pollution.

Эффективные Стратегии Профилактики Острого Ларингита У Детей: Современные Подходы

“…-Климатические условия: Холодный и сухой воздух также может способствовать развитию заболевания [7].…”

Structural racism, air pollution and the association with adverse birth outcomes in the United States: the value of examining intergenerational associations

“…Numerous studies conducted to date have evaluated long-term or pregnancy-wide exposure to air pollution and birth outcomes within a single generation ( 39 ). Others have evaluated pre- and postnatal exposures on child health outcomes ( 40 ). However, exposure to air pollution may have health impacts across generations that may not be fully accounted for using only prenatal exposures or exposures within a given generation.…”