Effect of Pre- and Post-Surgery Treatment with Risedronate on Trabecular Bone Loss in Ovariectomized Rats

Iwamoto, Jun; Takeda, Tsuyoshi; Satō, Yoshihiro; Shen, Chwan‐Li; Yeh, James K.

doi:10.1538/expanim.55.457

Cited by 5 publications

(2 citation statements)

References 18 publications

(17 reference statements)

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“…In the present study, 7 days after ovariectomy no differences in body weight were observed between groups as previously reported [49]. An increase in body weight in OVX mice was observed at the end of the experiments.…”

Section: Discussionsupporting

confidence: 90%

Aqueous Extract of Black Maca (Lepidium meyenii) on Memory Impairment Induced by Ovariectomy in Mice

Rubio

Wang

Liu

et al. 2011

Evidence-Based Complementary and Alternative Medicine

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The present study aims to test two different doses of aqueous extract of black maca on learning and memory in ovariectomized (OVX) mice and their relation with malonalehyde (MDA), acetylcholinesterase (Ache) and monoamine oxidase (MAO) brain levels. Female mice were divided into five groups: (i) naive (control), (ii) sham, (iii) OVX mice and OVX mice treated with (iv) 0.50 g kg−1 and (v) 2.00 g kg−1 black maca. Mice were orally treated with distilled water or black maca during 35 days starting 7 days after surgery. Memory and learning were assessed using the water Morris maze (from day 23–27) and the step-down avoidance test (days 34 and 35). At the end of each treatment, mice were sacrificed by decapitation and brains were dissected out for MDA, Ache and MAO determinations. Black maca (0.5 and 2.0 g/kg) increased step-down latency when compared to OVX control mice. Black maca decreased MDA and Ache levels in OVX mice; whereas, no differences were observed in MAO levels. Finally, black maca improved experimental memory impairment induced by ovariectomy, due in part, by its antioxidant and Ache inhibitory activities.

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Section: Discussionsupporting

confidence: 90%

Aqueous Extract of Black Maca (Lepidium meyenii) on Memory Impairment Induced by Ovariectomy in Mice

Rubio

Wang

Liu

et al. 2011

Evidence-Based Complementary and Alternative Medicine

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“…A second group (6/time point) received an OVX and was assigned to 2, 6, or 12 week time points. Statistical power analysis was conducted a priori, based on literature data from sham and OVX Sprague–Dawley rats (bone volume fraction: BV/TV = 0.18 ± 0.04 for sham and 0.06 ± 0.02 for OVX at 10 weeks post‐OVX). A difference in BV/TV of 0.06 (one half the 0.12 difference between the sham and OVX groups) between groups could be detected with a power of 90% with a p = 0.05.…”

Section: Methodsmentioning

confidence: 99%

Early Changes in Cement–Bone Fixation Using a Novel Rat Knee Replacement Model

Mann

Miller

Amendola

et al. 2019

Journal Orthopaedic Research

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Trabecular resorption from interdigitated regions between cement and bone has been found in postmortem‐retrieved knee replacements, but the viability of interdigitated bone, and the mechanism responsible for this bone loss is not known. In this work, a Sprague–Dawley (age 12 weeks) rat knee replacement model with an interdigitated cement–bone interface was developed. Morphological and cellular changes in the interdigitated region of the knee replacement over time (0, 2, 6, or 12 weeks) were determined for ovariectomy (OVX) and Sham OVX treatment groups. Interdigitated bone volume fraction (BV/TV) increased with time for Sham OVX (0.022 BV/TV/wk) and OVX (0.015 BV/TV/wk) group, but the rate of increase was greater for the Sham OVX group (p = 0.0064). Tissue mineral density followed a similar increase with time in the interdigitated regions. Trabecular resorption, when it did occur, started at the cement border with medullary‐adjacent bone in the presence of osteoclasts. There was substantial loss of viable bone (~80% empty osteocyte lacunae) in the interdigitated regions. Pre‐surgical fluorochrome labels remained in the interdigitated regions, and did not diminish with time, indicating that the bone was not remodeling. There was also some evidence of continued surface mineralization in the interdigitated region after cementing of the knee, but this diminished over time. Statement of clinical significance: Interdigitated bone with cement provides mechanical stability for success of knee replacements. Improved understanding of the fate of the interdigitated bone over time could lead to a better understanding of the loosening process and interventions to prevent loss of fixation. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:2163–2171, 2019

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Ovariectomy impairs spatial memory: prevention and reversal by a soy isoflavone diet

et al. 2008

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Since a previous study has shown that ovariectomy impairs spatial memory, we, herein, investigate the influence of pre- and post-treatment with a soy diet on the effects elicited by ovariectomy on spatial memory. In the pre-treatment, 20-day-old female Wistar rats were first fed for 60 days on a standard diet with casein (control) or a soy diet. At 80 days of age, the animals were assigned to one of the following groups: sham (submitted to surgery without removal of ovaries) and ovariectomized. One week after surgery, the rats were submitted to behavioral testing. In the post-treatment, 80-day-old female rats were assigned to one of the following groups: sham and ovariectomized. One week after surgery, animals were fed for 30 days with the same diet described above. Then, rats were submitted to water maze testing. Pre-treatment for two months before ovariectomy with the soy diet effectively prevented the increase in latency in finding the platform on the fifth day of training in the ovariectomized group. Ovariectomized rats subjected to soy diet post-treatment reversed the increase in latency to find the platform in the ovariectomized group on the fifth day of training and, the decrease in the time spent in target quadrant, the increase in the time spent in opposite quadrant and the latency to cross the platform location. Results show that both pre- and post-treatment protected against the impairment of memory, caused by ovariectomy. Post-treatment reversed various parameters of memory reference, indicating that post-treatment was more efficient than pre-treatment. Based on these findings, we suggest that soy diet (rich in isoflavones) may represent a novel therapeutic strategy to prevent or to treat cognitive symptoms found in some menopausal women.

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Effect of Pre- and Post-Surgery Treatment with Risedronate on Trabecular Bone Loss in Ovariectomized Rats

Cited by 5 publications

References 18 publications

Aqueous Extract of Black Maca (Lepidium meyenii) on Memory Impairment Induced by Ovariectomy in Mice

Aqueous Extract of Black Maca (Lepidium meyenii) on Memory Impairment Induced by Ovariectomy in Mice

Early Changes in Cement–Bone Fixation Using a Novel Rat Knee Replacement Model

Ovariectomy impairs spatial memory: prevention and reversal by a soy isoflavone diet

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