Effect of postconditioning on mitochondrial dysfunction in experimental aortic cross-clamping

Charles, Anne-Laure; Guilbert, Anne-Sophie; Bouitbir, Jamal; Marco, Paola Goette-Di; Enache, Irina; Zoll, Joffrey; Piquard, François; Gény, Bernard

doi:10.1002/bjs.7384

Cited by 49 publications

(62 citation statements)

References 79 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Such post-conditioning has been shown to reduce reperfusion-induced injury on occlusion of other vascular beds. 33 Third, we measured mitochondrial activity after gut IR in liver only. A multi-organ approach is severely hampered by the need to extract mitochondria from fresh tissue and measure oxygen consumption immediately.…”

Section: Discussionmentioning

confidence: 99%

Methylene Blue Protects Liver Oxidative Capacity after Gut Ischaemia–Reperfusion in the Rat

Collange

Charles

Bouitbir

et al. 2013

European Journal of Vascular and Endovascular Surgery

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Methylene Blue Protects Liver Oxidative Capacity after Gut Ischaemia–Reperfusion in the Rat

Collange

Charles

Bouitbir

et al. 2013

European Journal of Vascular and Endovascular Surgery

View full text Add to dashboard Cite

show abstract

“…With reoxygenation, the respiratory chain of undamaged mitochondria produces ATP and the mitochondrial membrane potential is recovered. However, in cells subjected to ischemia, reperfusion further alters the activity of mitochondrial complexes I-IV as described in experimental models and PAD (28,108,146,147,176,179). The impaired function decreases ATP synthesis (Fig.…”

Section: ϩmentioning

confidence: 89%

Chronology of mitochondrial and cellular events during skeletal muscle ischemia-reperfusion

Paradis

Charles

Meyer

et al. 2016

American Journal of Physiology-Cell Physiology

127

View full text Add to dashboard Cite

Peripheral artery disease (PAD) is a common circulatory disorder of the lower limb arteries that reduces functional capacity and quality of life of patients. Despite relatively effective available treatments, PAD is a serious public health issue associated with significant morbidity and mortality. Ischemia-reperfusion (I/R) cycles during PAD are responsible for insufficient oxygen supply, mitochondriopathy, free radical production, and inflammation and lead to events that contribute to myocyte death and remote organ failure. However, the chronology of mitochondrial and cellular events during the ischemic period and at the moment of reperfusion in skeletal muscle fibers has been poorly reviewed. Thus, after a review of the basal myocyte state and normal mitochondrial biology, we discuss the physiopathology of ischemia and reperfusion at the mitochondrial and cellular levels. First we describe the chronology of the deleterious biochemical and mitochondrial mechanisms activated by I/R. Then we discuss skeletal muscle I/R injury in the muscle environment, mitochondrial dynamics, and inflammation. A better understanding of the chronology of the events underlying I/R will allow us to identify key factors in the development of this pathology and point to suitable new therapies. Emerging data on mitochondrial dynamics should help identify new molecular and therapeutic targets and develop protective strategies against PAD.peripheral artery disease; ischemia-reperfusion; skeletal muscle; mitochondria; oxidative stress PERIPHERAL ARTERY DISEASE (PAD) refers to a common circulatory disorder of the lower limb caused by chronic narrowing of the arteries (e.g., stenosis and occlusion) or atherosclerosis. PAD represents a broad spectrum of disease severity, ranging from asymptomatic disease to frequent pain when walking (i.e., intermittent claudication or limping) or critical limb ischemia associated with decubitus pain and/or ulcers (114,126).PAD is known to be associated with reduced functional capacity and quality of life. It is a major cause of limb amputation, as well as an increased risk factor for myocardial infarction, stroke, and death. The incidence of PAD varies with age, from 3-10% in young people to 15-20% in people Ͼ70 yr of age, and is asymptomatic in 40% of the cases (1), with greater prevalence among men. The major PAD risk factors, including smoking, diabetes mellitus, dyslipidemia, hypertension, and obesity, are the same as those for cardiovascular and cerebrovascular diseases (35).Three main complementary treatment options improve the functional status and other clinical outcomes in PAD patients (54). 1) Optimization of medical therapy (i.e., pharmacotherapy) reduces the risk of cardiac ischemia, increases the distance a patient can walk, and improves the functional capacity of patients. 2) When possible, exercise training, a noninvasive and nonpharmacological therapy, improves walking ability and has protective effects in patients with PAD characterized by intermittent claudication and infrainguinal lesions...

show abstract

“…Besides the heart (Skyschally et al,2009), postconditioning is also effective in salvage of ischemic skeletal muscle from reperfusion injury and the mechanism likely involves inhibition of opening of the mPTP and/or reduced oxidative stress (Szijarto et al,2009;Tsubota et al, 2010;Park et al, 2010;Guyrkovic et al, 2011;Mc Allister et al, 2008;Charles et al, 2011). There are few human studies, but it has been showed that postconditioning by intermittent early reperfusion reduces ischemia/reperfusion injury, that might depend on K(ATP) channel activation, and is mimicked by inhibition of the mPTP at reperfusion (Okorie et al, 2011).…”

Section: Ischemic Pre-and Post-conditioningmentioning

confidence: 99%

Skeletal Muscle Mitochondrial Function in Peripheral Arterial Disease: Usefulness of Muscle Biopsy

Lejay¹,

Charles²,

Zoll³

et al. 2012

Muscle Biopsy

View full text Add to dashboard Cite

Effect of postconditioning on mitochondrial dysfunction in experimental aortic cross-clamping

Cited by 49 publications

References 79 publications

Methylene Blue Protects Liver Oxidative Capacity after Gut Ischaemia–Reperfusion in the Rat

Methylene Blue Protects Liver Oxidative Capacity after Gut Ischaemia–Reperfusion in the Rat

Chronology of mitochondrial and cellular events during skeletal muscle ischemia-reperfusion

Skeletal Muscle Mitochondrial Function in Peripheral Arterial Disease: Usefulness of Muscle Biopsy

Contact Info

Product

Resources

About