Skeletal Muscle Mitochondrial Function in Peripheral Arterial Disease: Usefulness of Muscle Biopsy

Lejay, Anne; Charles, Anne; Zoll, Joffrey; Bouitbir, Jamal; Thaveau, Fabien; Piquard, François; Gény, Bernard

doi:10.5772/31674

Cited by 4 publications

(4 citation statements)

References 76 publications

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“…It should be noted that in this research we studied the process of recovery of the dynamics of muscle contraction after long-term alcohol intoxication 1 month after the cessation of alcohol consumption. The choice of this particular term is related to data (Jung et al, 2011;de la Monte et al, 2014), which show that with complete abstinence from alcohol, the muscular and nervous systems recover for at least 30 days.…”

Section: Methodsmentioning

confidence: 99%

The effect of C60 fullerenes on the recovery of muscle soleus contraction dynamics in rats after chronic alcoholization

Nozdrenko,

Nan,

Motuziuk

et al. 2024

Biol. Stud.

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Background. It has been shown that the available therapeutic agents do not eliminate the consequences of miotic pathologies in chronic alcoholism, the most significant of which are disturbances in the dynamics of muscle contraction. A positive effect of biocompatible water-soluble C60 fullerenes on the contraction parameters of damaged muscles has been established. In addition, administration of C60 fullerene aqueous solution during chronic alcoholization of rats protects muscle tissue from damage caused by oxidative stress. Materials and Methods. Biomechanical parameters such as the values of the minimum and maximum contraction force and the muscle force impulse were evaluated using tensometry. The blood levels of creatine phosphokinase and lactate dehydrogenase, creatinine and lactate as well as the level of oxidative processes in muscle tissue of experimental animals (content of hydrogen peroxide, activity of catalase, glutathione peroxidase and superoxide dismutase) as markers of muscle damage were determined using methods of biochemical analysis. Results. The C60 fullerene aqueous solution effect on the skeletal muscle contraction dynamics in rats after chronic alcoholization for 9 months and cessation of alcohol consumption for 1 month was investigated. It was established that water-soluble C60 fullerenes (daily dose of 1 mg/kg) reduce the effects of chronic alcoholization by 35–40±2 % on the studied biomechanical parameters and by 20±1 % on the studied biochemical parameters compared to the group of alcoholized animals, thus increasing the energy capabilities of the muscular system. Conclusions. The obtained data indicate a pronounced protective effect of C60 fullerenes on the muscle soleus contraction dynamics during the development of alcoholic myopathy, which opens up the potential possibility of their use for the prevention and correction of miotic damage.

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Section: Methodsmentioning

confidence: 99%

The effect of C60 fullerenes on the recovery of muscle soleus contraction dynamics in rats after chronic alcoholization

Nozdrenko,

Nan,

Motuziuk

et al. 2024

Biol. Stud.

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“…Одним з наслідків хронічного вживання алкоголю є дисфункція мітохондрій [17], внаслідок чого продукується ще більше вільних радикалів [18]. Окрім того, алкоголь та ацетальдегід є потужніми інгібіторами синтези м'язового білка.…”

Section: результати та їх обговоренняunclassified

Dynamics of Contraction of the musculus soleus of Rats in Chronic Alcoholization and Therapeutic Action of Water-Soluble C60 Fullerenes

2019

Nanosist. Nanomater. Nanotehnol.

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 2019 ІМÔ (Інститут металофізики ім. Ã. В. Курдюмова НÀН Óкраїни) Надруковано в Óкраїні. Ôотокопіювання дозволено тільки відповідно до ліцензії 400 Д. М. НОЗДРЕНКО, О. П. МОТÓЗЮК, К. І. БОÃÓЦЬКÀ та ін. пии треморных флюктуаций силовых ответов мышцы. Ключові слова: С 60-фуллерен, musculus soleus, скорочення-розслабляння м'яза, алкогольна міопатія.

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“…I/R during PAD results in insuf-ficient oxygen supply secondary to reduced blood flow, mitochondriopathy leading to reduced energy supply, oxidative stress (i.e., imbalance between free radical production and elimination), and inflammation, which lead to intermittent claudication, limb pain at rest, ulcers, and, potentially, limb loss and increased morbidity/mortality (13,39,71,95,114,162) (Fig. 1).…”

mentioning

confidence: 99%

Chronology of mitochondrial and cellular events during skeletal muscle ischemia-reperfusion

Paradis

Charles

Meyer

et al. 2016

American Journal of Physiology-Cell Physiology

100

127

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Peripheral artery disease (PAD) is a common circulatory disorder of the lower limb arteries that reduces functional capacity and quality of life of patients. Despite relatively effective available treatments, PAD is a serious public health issue associated with significant morbidity and mortality. Ischemia-reperfusion (I/R) cycles during PAD are responsible for insufficient oxygen supply, mitochondriopathy, free radical production, and inflammation and lead to events that contribute to myocyte death and remote organ failure. However, the chronology of mitochondrial and cellular events during the ischemic period and at the moment of reperfusion in skeletal muscle fibers has been poorly reviewed. Thus, after a review of the basal myocyte state and normal mitochondrial biology, we discuss the physiopathology of ischemia and reperfusion at the mitochondrial and cellular levels. First we describe the chronology of the deleterious biochemical and mitochondrial mechanisms activated by I/R. Then we discuss skeletal muscle I/R injury in the muscle environment, mitochondrial dynamics, and inflammation. A better understanding of the chronology of the events underlying I/R will allow us to identify key factors in the development of this pathology and point to suitable new therapies. Emerging data on mitochondrial dynamics should help identify new molecular and therapeutic targets and develop protective strategies against PAD.peripheral artery disease; ischemia-reperfusion; skeletal muscle; mitochondria; oxidative stress PERIPHERAL ARTERY DISEASE (PAD) refers to a common circulatory disorder of the lower limb caused by chronic narrowing of the arteries (e.g., stenosis and occlusion) or atherosclerosis. PAD represents a broad spectrum of disease severity, ranging from asymptomatic disease to frequent pain when walking (i.e., intermittent claudication or limping) or critical limb ischemia associated with decubitus pain and/or ulcers (114,126).PAD is known to be associated with reduced functional capacity and quality of life. It is a major cause of limb amputation, as well as an increased risk factor for myocardial infarction, stroke, and death. The incidence of PAD varies with age, from 3-10% in young people to 15-20% in people Ͼ70 yr of age, and is asymptomatic in 40% of the cases (1), with greater prevalence among men. The major PAD risk factors, including smoking, diabetes mellitus, dyslipidemia, hypertension, and obesity, are the same as those for cardiovascular and cerebrovascular diseases (35).Three main complementary treatment options improve the functional status and other clinical outcomes in PAD patients (54). 1) Optimization of medical therapy (i.e., pharmacotherapy) reduces the risk of cardiac ischemia, increases the distance a patient can walk, and improves the functional capacity of patients. 2) When possible, exercise training, a noninvasive and nonpharmacological therapy, improves walking ability and has protective effects in patients with PAD characterized by intermittent claudication and infrainguinal lesions...

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Skeletal Muscle Mitochondrial Function in Peripheral Arterial Disease: Usefulness of Muscle Biopsy

Cited by 4 publications

References 76 publications

The effect of C60 fullerenes on the recovery of muscle soleus contraction dynamics in rats after chronic alcoholization

The effect of C60 fullerenes on the recovery of muscle soleus contraction dynamics in rats after chronic alcoholization

Dynamics of Contraction of the musculus soleus of Rats in Chronic Alcoholization and Therapeutic Action of Water-Soluble C60 Fullerenes

Chronology of mitochondrial and cellular events during skeletal muscle ischemia-reperfusion

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