Effect of porous structure of macroporous polymer supports on resolution in high-performance membrane chromatography of proteins

An Introduction to Monolithic Disks as Stationary Phases for High Performance Biochromatography

“…Over the last decade, a variety of polymer-based microgranulated sorbents (including a number of methacrylate-based ones) have become available as alternatives to silica-based beads, which as are known to cause problems in biochromatography. These polymeric beads are obtained by free radical copolymerization [27]. As a consequence of the polymerization conditions (presence of a porogen), these particles have a macroporous structure (Figure 3.b).…”

“…The space between such clusters of microglobules is relatively large (macropores), while between the globules smaller pores, so-called mesopores, are located. It has since been challenged whether this distinction is really necessary or whether the monolithic stationary phases should simply be considered as extremely porous (A50%) structures containing a set of highly cross-linked flow through pores with rather rough surface [27].…”

Nanofibre fabrication in a temperature and humidity controlled environment for improved fibre consistency

“…This study is particularly relevant to membrane operations which are commonly limited by poor membrane pore size uniformity and axial and radial diffusion which results in poor system dispersion, yielding low utilisation of membrane capacity [16,17]. Previous studies have highlighted the importance of designing a membrane with regards to the proposed system and operating conditions, optimising the membrane pore size by balancing mass transfer against and fouling issues [18][19][20].…”

Entropically driven self-assembly of colloidal crystals on templates in space

“…For example, macroporous polymers have been used as catalytic surfaces and supports, 165,166 separation and adsorbent media, [167][168][169] biomaterials, [170][171][172][173] and chromatographic materials. [174][175][176] Similarly macroporous ceramics can be employed as lightweight thermal and electrical insulators, as well as for catalysis. [177][178][179][180] Colloidal crystals are also of fundamental interest.…”