Effect of Polyvinylpyrrolidone-Iodine Liposomal Hydrogel on Wound Microcirculation in SKH1-&lt;i&gt;hr&lt;/i&gt; Hairless Mice

Langer, Stefan; Botteck, Nikolaj Matthias; Bosse, B.; Reimer, Karen; Vogt, Peter M.; Steinau, Hans-Ulrich; Müeller, Stefan

doi:10.1159/000091524

Cited by 27 publications

(12 citation statements)

References 52 publications

(35 reference statements)

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“…The effect of PVP-iodine liposomal hydrogel on wound healing and microcirculation was tested in the same animal model in 2005. The result was significantly speedier wound healing/angiogenesis compared to the control group and no effect on the microcirculatory parameters [5] . In the same model but a different study, PVP-iodine (10%) again showed the fastest angiogenesis but the slowest epithelialization of the wound -compared to silver sulphadiazine, silver nitrate, bacitracin, sodium hydrochloride and mafenide acetate [9] .…”

Section: Discussionmentioning

confidence: 82%

“…Using this mark a full-thickness dermal layer extending down to the underlying cartilage was excised by means of microsurgical scissors (Fine Science Tools GmbH, Heidelberg, Germany) under an operating microscope (Leica, Wetzlar, Germany). The preparation provided a full-thickness dermal wound of approximately 5 mm in surface area with a depth of approximately 120 m. The wound model had previously been described [3][4][5] .…”

Section: Wound Creationmentioning

confidence: 99%

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Evaluation of a Novel Polihexanide-Preserved Wound Covering Gel on Dermal Wound Healing

Goertz

Ring²,

Knie³

et al. 2009

Eur Surg Res

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Objective: Daily wound assessment, including dressing changes and the removal of old ointments causes discomfort for the patient. We therefore developed a new thermoreversible and transparent gel formulation that allows for filling wounds of different shapes and depths. The aim of the study was to investigate the effect of a wound covering gel on wound healing and the skin’s microcirculation. Materials and Methods: Investigations were carried out in a standardized and reproducible wound model (hairless mice SKH1/hr, n = 30). Three groups were studied by intravital fluorescence microscopy: treatment with polihexanide-preserved wound covering gel, a formulation containing 3% povidone (PVP)-iodine, and physiological saline for control. Microcirculatory standard parameters were analysed. Results: The non-perfused area vanished within 14 days due to angiogenesis. The venular diameter, oedema formation and functional capillary density showed no significant differences between the three groups. Conclusion: The use of the newly developed wound covering gel has no toxic effects on microcirculation and angiogenesis and reveals no significant differences in the overall assessment of microcirculation compared to the control group and the well-established PVP-iodine. The transparent antibacterial wound covering gel allows for direct wound assessment. Due to its thermoreversible gel formulation it enables good wound contact and easy handling.

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Section: Discussionmentioning

confidence: 82%

Section: Wound Creationmentioning

confidence: 99%

Evaluation of a Novel Polihexanide-Preserved Wound Covering Gel on Dermal Wound Healing

Goertz

Ring²,

Knie³

et al. 2009

Eur Surg Res

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“…Currently, among the various irrigation solutions, normal saline, iodophor and hydrogen peroxide are all used in the clinic (12). It has been reported that the iodine in iodophor can kill bacteria, improve microcirculation at the wound surface, promote wound healing and release iodine compounds with anti-inflammatory effects (13)(14)(15); however, iodophor has toxic effects on in vitro-cultured human skin fibroblasts and immunocytes. In addition, iodine can induce and aggravate hyperthyroidism and hypothyroidism, and iodine at high concentrations can promote apoptosis, which is disadvantageous to wound healing.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of different irrigation solutions on the early debridement of open fracture in rats

Cheng

Zhang

et al. 2015

Experimental and Therapeutic Medicine

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Abstract. Contaminating bacteria are only found on wound surfaces in the initial stages of open fractures; therefore, effective debridement is critical for bacterial infection prevention and the reduction of inflammatory reactions. Various irrigation solutions are currently being used; however, a comprehensive study on their efficacy is lacking. In the present study, a comparison of the effects of normal saline, iodophor and hydrogen peroxide as the irrigation solutions for debridement of open femur fractures in rat models was conducted. It was revealed that all three solutions were comparably effective in bacterial removal while normal saline was superior in minimizing adverse wound inflammation; therefore, the use of normal saline for routine debridement is recommended in the early-stage treatment of open fractures in the trauma clinic and in relief fieldwork.

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“…In animal experiments, the healing of skin wounds was significantly delayed by 2% PVP-I [161]. For PVP-I-L, proliferation and improvement of microcirculation have been demonstrated in in vitro and animal experiments [30,162,163]. In animal models, the application of C-I promotes epithelial cell regeneration and thus wound healing [164,165].…”

Section: Iodophorementioning

confidence: 99%

Consensus on Wound Antisepsis: Update 2018

Krämer

Dissemond²,

Kim³

et al. 2017

Skin Pharmacol Physiol

242

215

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Wound antisepsis has undergone a renaissance due to the introduction of highly effective wound-compatible antimicrobial agents and the spread of multidrug-resistant organisms (MDROs). However, a strict indication must be set for the application of these agents. An infected or critically colonized wound must be treated antiseptically. In addition, systemic antibiotic therapy is required in case the infection spreads. If applied preventively, the Wounds-at-Risk Score allows an assessment of the risk for infection and thus appropriateness of the indication. The content of this updated consensus recommendation still largely consists of discussing properties of octenidine dihydrochloride (OCT), polihexanide, and iodophores. The evaluations of hypochlorite, taurolidine, and silver ions have been updated. For critically colonized and infected chronic wounds as well as for burns, polihexanide is classified as the active agent of choice. The combination 0.1% OCT/phenoxyethanol (PE) solution is suitable for acute, contaminated, and traumatic wounds, including MRSA-colonized wounds due to its deep action. For chronic wounds, preparations with 0.05% OCT are preferable. For bite, stab/puncture, and gunshot wounds, polyvinylpyrrolidone (PVP)-iodine is the first choice, while polihexanide and hypochlorite are superior to PVP-iodine for the treatment of contaminated acute and chronic wounds. For the decolonization of wounds colonized or infected with MDROs, the combination of OCT/PE is preferred. For peritoneal rinsing or rinsing of other cavities with a lack of drainage potential as well as the risk of central nervous system exposure, hypochlorite is the superior active agent. Silver-sulfadiazine is classified as dispensable, while dyes, organic mercury compounds, and hydrogen peroxide alone are classified as obsolete. As promising prospects, acetic acid, the combination of negative pressure wound therapy with the instillation of antiseptics (NPWTi), and cold atmospheric plasma are also subjects of this assessment.

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Effect of Polyvinylpyrrolidone-Iodine Liposomal Hydrogel on Wound Microcirculation in SKH1-<i>hr</i> Hairless Mice

Cited by 27 publications

References 52 publications

Evaluation of a Novel Polihexanide-Preserved Wound Covering Gel on Dermal Wound Healing

Evaluation of a Novel Polihexanide-Preserved Wound Covering Gel on Dermal Wound Healing

Efficacy of different irrigation solutions on the early debridement of open fracture in rats

Consensus on Wound Antisepsis: Update 2018

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