Effect of polysaccharides from Tibetan turnip (Brassica rapaL.) on the gut microbiome afterin vitrofermentation andin vivometabolism

Qian, He; Li, Lin; Liu, Chang; Hua, Hanyi; Zhao, Wenjin; Zhu, Hongkang; Cheng, Yuliang; Guo, Yahui

doi:10.1039/d1fo03821d

Cited by 10 publications

(9 citation statements)

References 52 publications

(54 reference statements)

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“…The function of polysaccharides depends on their molecular weight and structure. According to our previous study, the Mw of TTP did not change significantly after gastrointestinal digestion, indicating that TTP was not easily degraded ( Liu et al, 2022 ). In the intestine, anaerobes use glucose (31.28%) and mannose (19.82%) in TTP to produce acetic acid.…”

Section: Discussionmentioning

confidence: 85%

Healthy regulation of Tibetan Brassica rapa L. polysaccharides on alleviating hyperlipidemia: A rodent study

Hua

Liu

Zhu

et al. 2023

Food Chemistry: Molecular Sciences

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Section: Discussionmentioning

confidence: 85%

Healthy regulation of Tibetan Brassica rapa L. polysaccharides on alleviating hyperlipidemia: A rodent study

Hua

Liu

Zhu

et al. 2023

Food Chemistry: Molecular Sciences

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“…We have discovered that Brassica rapa L. extract can optimize probiotics in vitro fermentation, suggesting its potential function in gut health [15]. These findings provide a theoretical basis for the deep investigation of the bioactive mechanism of Brassica rapa L. through its influence on the gut-muscle axis.…”

Section: Introductionmentioning

confidence: 79%

Aqueous Extract of Brassica rapa L.’s Impact on Modulating Exercise-Induced Fatigue via Gut–Muscle Axis

Wang,

Zhu,

Cheng

et al. 2023

Nutrients

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Exercise-induced fatigue is a common physiological response to prolonged physical activity, often associated with changes in gut microbiota and metabolic responses. This study investigates the potential role of Brassica rapa L. in modulating these responses. Using an animal model subjected to chronic exercise-induced stress, we explored the effects of Brassica rapa L. on fatigue-related biomarkers, energy metabolism genes, inflammatory responses, intestinal integrity, and gut microbiota composition. Our findings revealed that Brassica rapa L. exhibits significant antioxidant activity and effectively modulates physiological responses to fatigue. It influences gene expression related to the tricarboxylic acid (TCA) cycle in muscle tissue through the AMPK/PGC-1α/TFAM signaling pathway. Furthermore, Brassica rapa L. has been found to alleviate inflammation by inhibiting lipopolysaccharide (LPS) infection and suppressing the activation of the NF-κB pathway. It also maintains intestinal integrity and controls Gram-negative bacterial growth. A correlation analysis identified several pathogenic bacteria linked with inflammation and energy metabolism, as well as beneficial probiotic bacteria associated with improved energy metabolism and reduced inflammation. These findings underscore Brassica rapa L.’s potential for managing prolonged exercise-induced fatigue, paving the way for future therapeutic applications. The results highlight its impact on gut microbiota modulation and its role in nutrition science and sports medicine.

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“…Research showed that the abundance of Firmicutes in obese patients was higher, while the abundance of Bacteroidetes was significantly lower than that in healthy people. Liu et al also found that the ratio of Firmicutes/Bacteroidetes in the gut microbiota of healthy people was high [21]. Previous studies have shown that the increase in Bacteroidetes was associated with overweight and obesity in pregnant women, which may increase the risk of intrauterine diseases in pregnant women [22,23].…”

Section: Changes In Community Structure and Compositionmentioning

confidence: 96%

The Dynamic Changes in the Composition and Diversity of Vaginal Microbiota in Women of Different Pregnancy Periods

Hu,

Sun,

et al. 2023

Microorganisms

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The vaginal microbiota undergoes subtle changes during pregnancy, which may affect different pregnancy responses. This study used the Illumina MiSeq high-throughput sequencing method to analyze the 16S rRNA gene amplicons of pregnant women and the vaginal microbiota structure of pregnant women at different pregnancy periods. There were a total of 15 pregnant women, with 45 samples were taken from these women, within half a year before becoming pregnant, in the last trimester, and 42 days postpartum. Before and after pregnancy, the female vaginal microbiota was mainly composed of Firmicutes, followed by Actinobacteriota and Proteobacteria. The abundance of Lactobacillus was relatively high. The α-diversity and microbial abundance were relatively low, and there was no significant difference in microbial composition between the two. After childbirth, the diversity and abundance of women’s vaginal bacterial communities were higher, with a decrease in the number of Firmicutes and a higher abundance of Actinobacteria, Proteobacteria, and Bacteroidota. There was a significant difference in the microbial community structure before and after pregnancy. This study showed that the microbiota structure of the vagina of pregnant women was similar to before pregnancy, but after childbirth, there were significant changes in the microbiota of the vagina, with a decrease in the number of probiotics and an increase in the number of harmful bacteria, increasing the risk of illness.

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Effect of polysaccharides from Tibetan turnip (Brassica rapaL.) on the gut microbiome afterin vitrofermentation andin vivometabolism

Abstract: Tibetan turnip ( Brassica rapa L. ) polysaccharide (TTP) is an active ingredient and has been studied for many years due to its biological effect. There are few studies on...

Cited by 10 publications

References 52 publications

Healthy regulation of Tibetan Brassica rapa L. polysaccharides on alleviating hyperlipidemia: A rodent study

Healthy regulation of Tibetan Brassica rapa L. polysaccharides on alleviating hyperlipidemia: A rodent study

Aqueous Extract of Brassica rapa L.’s Impact on Modulating Exercise-Induced Fatigue via Gut–Muscle Axis

The Dynamic Changes in the Composition and Diversity of Vaginal Microbiota in Women of Different Pregnancy Periods

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