Effect of Polysaccharides and Human Plasma Lipoproteins on the Secretion of Cystatin C by Peritoneal Macrophages from Normal and Tumor Bearing Mice

Poteryaeva, O. N.; Polyakov, L. M.; Короленко, Т. А.; Зуева, Т. В.; Russkikh, G. S.; Панин, Л. Е.

doi:10.1023/b:biry.0000022060.42486.8b

Cited by 2 publications

(2 citation statements)

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“…Peritoneal macrophages from mice with experimental HA-1 hepatoma secreted ascitic fluid compared to those from intact mice secreted more Cystatin C with maximum polysaccha-ride-stimulated secretion after 30 min of incubation. LDL and HDL induced Cystatin C secretion by tumor macrophages also 79 .…”

Section: Neoplasiamentioning

confidence: 84%

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Clinical Role, Diagnostic and Prognostic Value of Human Cystatin C Through the Body

Viniegra¹,

Shiguetomi²,

Glogauer³

2018

CMRJ

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Cystatin C is a low-molecular-weight biomarker that meets the conditions necessary to be a marker of the glomerular filtration rate. This endogenous cysteine proteinase inhibitor belonging to the type 2 cystatin superfamily plays a key role in health and disease. Human cystatin C is encoded by the CST3 gene, ubiquitously expressed at moderate levels throughout the body, given it is produced in all nucleated cells in a constant amount. It is present in all human body fluids, and may be determined in the serum, plasma, capillary blood and urine. In this review, we present and discuss most of the available data from the literature for the use of cystatin C in clinical practice. In addition to a kidney function marker, studies suggest cystatin C could be used as a marker for cardiovascular risk assessment, in predicting and detecting preeclampsia, in patients with malignant neoformations, etc. Local cystatin C deficiency has also been demonstrated in atherosclerosis, aneurismal lesions, among others, suggesting a protective role of cystatin C. Far beyond its humble beginning, it promises uses from prognosis to treatments for everything from prostate cancer to periodontal disease. Cystatin C has begun its journey into a multitude of disciplines; we can only begin to imagine the many more purposes yet to find going forward.

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Section: Neoplasiamentioning

confidence: 84%

“…Some studies have shown that malignant conditions and liver disorders can bring about alterations in serum Cystatin C level 33 . Mice that have hepatocellular carcinoma induced produce ascitic fluid rich in peritoneal macrophages that secrete Cystatin C even more intensely than those of intact mice 79 .…”

Section: Livermentioning

confidence: 96%