Abstract:Cystatin C is a low-molecular-weight biomarker that meets the conditions necessary to be a marker of the glomerular filtration rate. This endogenous cysteine proteinase inhibitor belonging to the type 2 cystatin superfamily plays a key role in health and disease. Human cystatin C is encoded by the CST3 gene, ubiquitously expressed at moderate levels throughout the body, given it is produced in all nucleated cells in a constant amount. It is present in all human body fluids, and may be determined in the serum, … Show more
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