Effect of Polymer Molecular Weight on Nanocomminution of Poorly Soluble Drug

Choi, Ji-Yeun; Park, Chul Ho; Lee, Jonghwi

doi:10.1080/10717540802039113

Cited by 58 publications

(24 citation statements)

References 25 publications

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“…Choi et al [13] observed that for cellulose derivatives, shorter chain lengths provided a better (short-term) stabilization due to an increased rate of diffusion and adsorption. For the cellulose derivatives under investigation this observation could be confirmed in the present study.…”

Section: Resultsmentioning

confidence: 98%

“…Therefore, the selection of an adequate stabilizer for the system under investigation becomes a major challenge. Up to now, no quick and rational stabilizer selection method exists although several attempts were made to correlate physicochemical properties of the drug substance to those of adequate stabilizing agents [11][12][13][14] determination of adsorption isotherms [15] can help to understand the interactions between API and stabilizer and to identify an adequate stabilizer concentration. As this method is very time consuming, particularly for unknown systems, screening studies are still required to identify a suitable formulation.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Process parameter dependent growth phenomena of naproxen nanosuspension manufactured by wet media milling

Bitterlich¹,

Laabs²,

Krautstrunk³

et al. 2015

European Journal of Pharmaceutics and Biopharmaceutics

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Section: Resultsmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Process parameter dependent growth phenomena of naproxen nanosuspension manufactured by wet media milling

Bitterlich¹,

Laabs²,

Krautstrunk³

et al. 2015

European Journal of Pharmaceutics and Biopharmaceutics

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“…The nanoencapsulation of DMEO yielded entrapment efficiencies of 89.53±0.307, 89.46±0.211, 90.31±0.352% with particle sizes of 227.55±0.231, 253.96±0.012, and 255.09±0.455 nm, respectively. It is generally considered that higher molecular weight polymers have less entropy loss related to their fast motion, which results in a higher affinity to drug surfaces 10 , and they therefore perhaps have better steric formation. The charge along the polymer chains can build a strong double layer surrounding the particles, granting electrostatic stabilization and therefore smaller particle size 11 .…”

Section: Discussionmentioning

confidence: 99%

“…DMEO was previously synthesized and characterized as a white powder 10 . 10 mg of DMEO was dissolved in 10 mL of methanol, which was then added to polymeric nanocapsules.…”

Section: Methodsmentioning

confidence: 99%

Characterization and stability evaluation of nanoencapsulated epoxylignans

et al. 2018

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3',6-dimethoxy-3'',4''-(methylenedioxy)-2,5-epoxylignan-4'-ol (DMEO), an epoxylignan isolated from Piper nigrum, has currently captured attention for its potential antitumor effect. However, low stability is limiting its therapeutic application. The application of nanocapsulation would be the main strategy for overcoming this problem. DMEO-loaded nanocapsules were prepared by an emulsion-diffusion method using Eudragit RL 100 (at concentrations of 1, 1.5 and 2%) and polyvinyl alcohol. As the polymer content increased, the encapsulation efficiency and mean particle size also increased. After 6 months of storage at 25°C (0% RH), no crystalline peaks were observed in the diffraction patterns of all nanocapsules, thereby suggested that the physical stability of nanoencapsulated DMEO was not affected by the concentration ratio of the polymer−stabilizer combinations.

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“…The suspension stability can also be affected by the molecular weight of the polymer used. As shown by Choi [15] , 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 the effects on particle size reduction were more pronounced with lower molecular weight polymers early during milling, but this difference disappeared upon prolonged milling. The study concluded that the kinetic aspects of polymer molecular weight are important and suggest that a polymer with a lower molecular weight is more suitable for efficient stabilization in wet media milling.…”

Section: Introductionmentioning

confidence: 87%

Polymeric Stabilization of Nano‐Scale HMX Suspensions During Wet Milling

Doukkali

Gauthier

Patel

et al. 2019

Propellants Explo Pyrotec

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The focus of this paper is to investigate the polymeric stabilization of cyclotetramethylene tetranitramine (HMX) suspensions using polyvinylpyrrolidone (PVP). The PVP adsorption on HMX surface was studied using zeta potential measurements, which revealed that the shorter PVP polymer chain (lesser molecular weight) adsorbed better than the longer one (greater molecular weight). This study also showed that the solvent dramatically affects the PVP adsorption. A turbidity test was conducted, showing that lower molecular weight PVP offers better stability. This stability is enhanced by increasing the ethanol concentration. The depletion mechanism was responsible for HMX stabilization with ethanol. Finally, a milling study was conducted to compare the HMX with and without a stabilization mechanism. This study indicated that PVP in 50 % water/50 % ethanol was able to stabilize HMX by depletion and reduce the size to 180 nm within 10 minutes of milling. Strong aggregation was observed for HMX milled in the absence of the stabilization mechanism. The stabilization techniques discussed in this study appeared to lead to a shorter processing time and a more efficient milling process when utilized. Under comparable milling conditions, a particle size of 180 nm could be achieved with stabilization compared to 500 nm without. Such a dramatic improvement of the milling process bodes well for future nanoHMX production, as well as that of similar materials.

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Effect of Polymer Molecular Weight on Nanocomminution of Poorly Soluble Drug

Cited by 58 publications

References 25 publications

Process parameter dependent growth phenomena of naproxen nanosuspension manufactured by wet media milling

Process parameter dependent growth phenomena of naproxen nanosuspension manufactured by wet media milling

Characterization and stability evaluation of nanoencapsulated epoxylignans

Polymeric Stabilization of Nano‐Scale HMX Suspensions During Wet Milling

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