Effect of Polymer Molecular Weight on the Production of Drug Nanoparticles

Characterisation of Chitosan-Coated Vesicles Encapsulating DNA Suitable for Gene Delivery

“…55 It is essential therefore that the assay used to determine absorption is independent of molecular weight or else a false estimate of the extent of absorption could result. 56 The extent of chitosan-binding obtained from the UV/Vis assay in the present study was much higher than had been expected. It was unfortunate that it was not possible to compare the values obtained here with literature values.…”

Ultrasonic degradation for molecular weight reduction of pharmaceutical cellulose ethers

“…Of particular relevance to the present study is the use of hydrophilic polymers, such as HMPC, to produce nanoparticles of hydrophobic drug via wet bead milling (Goodwin, 2006;Sepassi et al, 2007). When preparing these polymer-coated nanoparticles using the limited molecular weight range of HPMC commercially available, it was noticed that stable nanoparticles were produced more rapidly and over a wider range of polymer concentrations when the lower molecular weight polymers were used.…”

Interaction Studies Between Indomethacin Nanocrystals and PEO/PPO Copolymer Stabilizers

“…However, often too many variables with stabilizers and drug compounds make the systematic analysis complicated. Accordingly, the effect of molecular weight has been studied with different HPMC grades as a stabilizer for nabumetone nanocrystals (17), whereas Lee et al (18,19) studied the interactions by using polymers with different amine acid units in order to understand the effect of chain composition, morphology and functional groups on drug nanocrystal stabilization. As of today, the selection of proper stabilizer for nanocrystallization is mostly based on trial and error.…”