Effect of polyHIPE porosity on its hydrodynamic properties

Mravljak, Rok; Bizjak, Ožbej; Podlogar, Matejka; Podgornik, Aleš

doi:10.1016/j.polymertesting.2020.106590

Cited by 13 publications

(26 citation statements)

References 40 publications

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“…PolyHIPE polymers exhibited a typical microstructure and high uniformity. In Figure 1 a, porous structure uniformity is demonstrated via five assembled SEM images showing the cross-section of the entire polymer (at 35× magnification) and further confirmed by uniform peaks shown in Figure 1 d obtained by the overlapping pulse response experiments performed at different flow rates [ 34 ]. The higher-magnification SEM images in Figure 1 b,c show the open polyHIPE morphology with spherical void pores (VPs) connected with circular interconnecting pores (IPs) with the corresponding pore size distributions fitted with the log-normal distribution curve ( Figure 1 e,f).…”

Section: Resultsmentioning

confidence: 57%

“…The higher-magnification SEM images in Figure 1 b,c show the open polyHIPE morphology with spherical void pores (VPs) connected with circular interconnecting pores (IPs) with the corresponding pore size distributions fitted with the log-normal distribution curve ( Figure 1 e,f). The absence of dead-end pores proves that the entire surface can be fully accessed by convection [ 34 ], and therefore no diffusion limitations, which would potentially affect the catalytic reaction, are expected.…”

Section: Resultsmentioning

confidence: 99%

“…Hydrodynamic properties and homogeneity were evaluated with pulse experiments [ 34 ] and scanning electron microscopy (SEM) imaging. An amount of 40 μL of diluted aqueous acetone solution was injected at a flow rate of 1–3 mL/min on the high-performance liquid chromatography (HPLC) equipment (ÄKTAexplorer, Uppsala, Sweden).…”

Section: Methodsmentioning

confidence: 99%

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Flow-Through PolyHIPE Silver-Based Catalytic Reactor

et al. 2021

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Catalytic reactors performing continuously are an important step towards more efficient and controllable processes compared to the batch operation mode. For this purpose, homogenous high internal phase emulsion polymer materials with an immobilized silver catalyst were prepared and used as a continuous plug flow reactor. Porous material with epoxide groups was functionalized to bear aldehyde groups which were used to reduce silver ions using Tollens reagent. Investigation of various parameters revealed that the mass of deposited silver depends on the aldehyde concentration as well as the composition of Tollens reagent. Nanoparticles formed on the pore surface showed high crystallinity with a cuboctahedra crystal shape and highly uniform surface coverage. The example of the 4-nitrophenol catalytic reduction in a continuous process was studied and demonstrated to be dependent on the mass of deposited silver. Furthermore, productivity increased with the volumetric silver density and flow rate, and it was preserved during prolonged usage and storage.

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Section: Resultsmentioning

confidence: 57%

Section: Resultsmentioning

confidence: 99%

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Flow-Through PolyHIPE Silver-Based Catalytic Reactor

et al. 2021

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“…PolyHIPE particles were synthesized using a similar composition reported previously for polyHIPE monolith preparation [ 48 ]. To prepare 30 mL of HIPE, first, the organic phase was prepared in a tall 100 mL beaker consisting of 2.188 g GMA, 1.003 g EGDMA, 0.348 g PL121, and 0.016 g IC819.…”

Section: Methodsmentioning

confidence: 99%

Bacteriophage Delivery Systems Based on Composite PolyHIPE/Nanocellulose Hydrogel Particles

et al. 2021

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The role of bacteriophage therapy in medicine has recently regained an important place. Oral phage delivery for gastrointestinal treatment, transport through the stomach, and fast release in the duodenum is one of such applications. In this work, an efficient polyHIPE/hydrogel system for targeted delivery of bacteriophages with rapid release at the target site is presented. T7 bacteriophages were encapsulated in low crosslinked anionic nanocellulose-based hydrogels, which successfully protected phages at pH < 3.9 (stomach) and completely lost the hydrogel network at a pH above 3.9 (duodenum), allowing their release. Hydrogels with entrapped phages were crosslinked within highly porous spherical polyHIPE particles with an average diameter of 24 μm. PolyHIPE scaffold protects the hydrogels from mechanical stimuli during transport, preventing the collapse of the hydrogel structure and the unwanted phage release. On the other hand, small particle size, due to the large surface-to-volume ratio, enables rapid release at the target site. As a consequence, a fast zero-order release was achieved, providing improved patient compliance and reduced frequency of drug administration. The proposed system therefore exhibits significant potential for a targeted drug delivery in medicine and pharmacy.

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“…Due to high porosity and macroporous structure of polyHIPEs, this kind of monoliths have attracted attention as chromatographic stationary phases for different modes of HPLC and solid-phase extraction [85][86][87]. Recently, the preparation of polyHIPE monoliths for thin layer chromatography was reported by Yin et al [48].…”

Section: Polyhipe Monolithic Layersmentioning

confidence: 99%

Macroporous Polymer Monoliths in Thin Layer Format

2021

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Nowadays, macroporous polymer monoliths represent widely used stationary phases for a number of dynamic interphase mass exchange processes such as high-performance liquid chromatography, gas chromatography, electrochromatography, solid-phase extraction, and flow-through solid-state biocatalysis. This review represents the first summary in the field of current achievements on the preparation of macroporous polymer monolithic layers, as well as their application as solid phases for thin-layer chromatography and different kinds of microarray.

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Effect of polyHIPE porosity on its hydrodynamic properties

Cited by 13 publications

References 40 publications

Flow-Through PolyHIPE Silver-Based Catalytic Reactor

Flow-Through PolyHIPE Silver-Based Catalytic Reactor

Bacteriophage Delivery Systems Based on Composite PolyHIPE/Nanocellulose Hydrogel Particles

Macroporous Polymer Monoliths in Thin Layer Format

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