Effect of poly(ethylene oxide)-silane graft molecular weight on the colloidal properties of iron oxide nanoparticles for biomedical applications

Monocorevs.multicore magnetic iron oxide nanoparticles: uptake by glioblastoma cells and efficiency for magnetic hyperthermia

“…17 In previous reports studying stealth IONPs in vitro or in vivo, phosphonic acid anchors were rather grafted along the polymer backbone, either in a block structure with PEG 18,19 or as a statistical copolymer with PEG sidechains. 20 Other types of anchoring moieties are also used for IONP pegylation, like nitrodopamine 21 or silanes 22,23 . In the present study, the near infrared (NIR) fluorescent dye DY700 that is stable under in vitro conditions and has low cytotoxicity 24 was also grafted using the phosphonate pre-functionalisation strategy in order to easily track the IONPs incubated with cells.…”

Magnetic iron oxide nanoparticles: Recent trends in design and synthesis of magnetoresponsive nanosystems

“…In the latter polymer functional groups are anchored to the IONP's surface, forming brush-like chains. As demonstrated, for example, in the work of Rinaldi and co-authors [110,111], covalent anchoring in many instances can enhance colloidal stability as compared with the adsorption of coating molecules. If a chemical surface modification is used, all the applied chemicals and by-products should be removed in order to reduce the chemical hazard of the formulation [112].…”

“…Besides these one should consider the hydration effects, the hydrophobic interactions and the steric stabilization [113]. In case of magnetic particles, the attraction between magnetic dipoles, the magnetic dipolar interaction also should be considered [114] to get theoretical stability predictions comparable to experimental results [111].…”

Folate-Conjugated pH-Responsive Nanocarrier Designed for Active Tumor Targeting and Controlled Release of Gemcitabine

“…To fulfil this purpose, in the first step, PEG (Mw=1500 g/mmol) was oxidized by Jones reagent [28]. Then, 5 g of PEG was dissolved in 30 mL of acetone and then it was heated to transform into a clear and homogeneous solution.…”