Monocore<i>vs.</i>multicore magnetic iron oxide nanoparticles: uptake by glioblastoma cells and efficiency for magnetic hyperthermia

Hemery, Gauvin; Genevois, Coralie; Couillaud, Franck; Lacomme, Sabrina; Gontier, Etienne; Ibarboure, Emmanuel; Lecommandoux, Sébastien; Garanger, Élisabeth; Sandre, Olivier

doi:10.1039/c7me00061h

Cited by 59 publications

(50 citation statements)

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“…They show high magnetic properties (specific magnetizations close to those of the bulk maghemite and magnetic susceptibility per particle χ up to 100) and are superparamagnetic despite their relatively large size. More recently, the same authors have managed to stabilize their multicore particles in water thank to polyethylene glycol (PEG) molecules with phosphonate anchoring groups; they internalized their IONPs into cancer cells and provoked the cell death by heating nanoparticles with an alternating radiofrequency magnetic field (so-called magnetic hyperthermia) [ 37 ].…”

Section: Introductionmentioning

confidence: 99%

“…Comparison of these timescales will inform us whether the field-induced aggregation is fast enough to enhance the efficiency of magnetic separation. To assess realistic behaviors in conditions close to immunoassays, the multicore IONPs will be covered with biocompatible PEG molecules at molar mass 6000 g/mol and grafting densities corresponding to the repulsive polymer brush regime [ 37 ]. The effect of the grafted layer thickness will be inspected by comparing performances of PEGylated multicore IONPs with citrated ones, citrates being the most common ligand used in the literature to disperse nanoflowers in water [ 38 , 39 ].…”

Section: Introductionmentioning

confidence: 99%

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Kinetics of Aggregation and Magnetic Separation of Multicore Iron Oxide Nanoparticles: Effect of the Grafted Layer Thickness

et al. 2018

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In this work, we have studied field-induced aggregation and magnetic separation—realized in a microfluidic channel equipped with a single magnetizable micropillar—of multicore iron oxide nanoparticles (IONPs) also called “nanoflowers” of an average size of 27 ± 4 nm and covered by either a citrate or polyethylene (PEG) monolayer having a thickness of 0.2–1 nm and 3.4–7.8 nm, respectively. The thickness of the adsorbed molecular layer is shown to strongly affect the magnetic dipolar coupling parameter because thicker molecular layers result in larger separation distances between nanoparticle metal oxide multicores thus decreasing dipolar magnetic forces between them. This simple geometrical constraint effect leads to the following important features related to the aggregation and magnetic separation processes: (a) Thinner citrate layer on the IONP surface promotes faster and stronger field-induced aggregation resulting in longer and thicker bulk needle-like aggregates as compared to those obtained with a thicker PEG layer; (b) A stronger aggregation of citrated IONPs leads to an enhanced retention capacity of these IONPs by a magnetized micropillar during magnetic separation. However, the capture efficiency Λ at the beginning of the magnetic separation seems to be almost independent of the adsorbed layer thickness. This is explained by the fact that only a small portion of nanoparticles composes bulk aggregates, while the main part of nanoparticles forms chains whose capture efficiency is independent of the adsorbed layer thickness but depends solely on the Mason number Ma. More precisely, the capture efficiency shows a power law trend Λ∝Ma−n, with n ≈ 1.4–1.7 at 300 < Ma < 104, in agreement with a new theoretical model. Besides these fundamental issues, the current work shows that the multicore IONPs with a size of about 30 nm have a good potential for use in biomedical sensor applications where an efficient low-field magnetic separation is required. In these applications, the nanoparticle surface design should be carried out in a close feedback with the magnetic separation study in order to find a compromise between biological functionalities of the adsorbed molecular layer and magnetic separation efficiency.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Kinetics of Aggregation and Magnetic Separation of Multicore Iron Oxide Nanoparticles: Effect of the Grafted Layer Thickness

et al. 2018

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“…10,11 They have attracted considerable attention for hyperthermia applications, owing to their ability to generate heat when exposed to an alternating magnetic field (AMF). [12][13][14][15][16][17][18][19][20] However, iron oxide nanoparticles are rarely used without coating protection due to their easy aggregation, their quick biodegradation, and their further loss of magnetic properties. 21,22 The iron oxide surface is usually modified with an inorganic layer, [23][24][25] such as silica, metal oxide or metal sulfide or by the grafting of organic molecules, including surfactants, biomolecules or polymers 26,27 such as polyacrylic acid 28 or dextran.…”

Section: Introductionmentioning

confidence: 99%

Thermal Polymerization on the Surface of Iron Oxide Nanoparticles Mediated by Magnetic Hyperthermia: Implications for Multishell Grafting and Environmental Applications

Griffete

Fresnais

Espinosa

et al. 2018

ACS Appl. Nano Mater.

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“…12,13 3. Results and Discussion 14 These results are conrmed using SEM image, and SEM image also provides useful information about particles size and morphology [ Fig. 1(c)].…”

Section: Characterization Techniquementioning

confidence: 58%

Casein-Coated Iron Oxide Nanoparticles for in vitro Hyperthermia for Cancer Therapy

Bani

Hatamie

Haghpanahi

et al. 2019

SPIN

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Iron oxide nanoparticles (NPs) have been a very appealing choice in magnetic-mediated hyperthermia for cancer therapy. The responses of NPs to hyperthermia as a cancer treatment method are complex and variable. Herein, the heating properties of the casein-coated magnetic NPs (MNPs) under an alternating magnetic field were investigated. The casein-coated MNPs were synthesized via one-pot chemical method. The casein-coated MNPs were characterized using transmission electron microscopy (TEM), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDAX), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), zeta potential, dynamic light scattering (DLS), and vibrating sample magnetometer (VSM) analysis. TEM images of casein-coated MNPs show that their shapes are spherical and their core sizes are between 20[Formula: see text]nm and 25[Formula: see text]nm. The FTIR and EDAX results confirmed the presence of casein on the surface of MNPs. The VSM shows the superparamagnetic nature of iron oxide and casein-coated iron oxide NPs with the magnetic saturation of 60[Formula: see text]emu/g and 44.86[Formula: see text]emu/g, respectively, at room temperature. Furthermore, hyperthermia tests for casein-coated MNPs with various concentrations and frequencies are performed. Hyperthermia results show that lower concentrations of casein-coated MNPs dispatch higher heating into their surrounding medium, whereas maximum specific absorption rate occurs at the concentration of 1[Formula: see text]mg/mL for the frequency of 150[Formula: see text]kHz. Findings of this study suggest that casein-coated MNPs have great potential as an anticancer agent in hyperthermia cancer therapy.

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Monocorevs.multicore magnetic iron oxide nanoparticles: uptake by glioblastoma cells and efficiency for magnetic hyperthermia

Abstract: PEGylated magnetic iron oxide nanoparticles (IONPs) were synthesised with the aim to provide proof of concept results of remote cancer cell killing by magnetic fluid hyperthermia.

Cited by 59 publications

References 40 publications

Kinetics of Aggregation and Magnetic Separation of Multicore Iron Oxide Nanoparticles: Effect of the Grafted Layer Thickness

Kinetics of Aggregation and Magnetic Separation of Multicore Iron Oxide Nanoparticles: Effect of the Grafted Layer Thickness

Thermal Polymerization on the Surface of Iron Oxide Nanoparticles Mediated by Magnetic Hyperthermia: Implications for Multishell Grafting and Environmental Applications

Casein-Coated Iron Oxide Nanoparticles for in vitro Hyperthermia for Cancer Therapy

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