Effect of plumbagin free alcohol extract of Plumbago zeylanica Linn. root on reproductive system of female Wistar rats

Gupta, Seema; Ahirwar, Dheeraj; Sharma, Neeraj Kumar; Jhade, Deenanath; Ahirwar, Bharti

doi:10.1016/s1995-7645(11)60230-7

Cited by 26 publications

(17 citation statements)

References 11 publications

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“…A positive correlation has been established between testosterone level and motility, density and fertilizing capacity of the spermatozoa. It has been reported that androgen binding protein and testosterone produced by the Leydig cells reaches to the epididymis through the testicular fluid and maintains the Epididymis testosterone level 119,120,121 . Since testosterone level affect the functional integrity of testis and epididymis, motility density and viability of spermatozoa suggests that Withania somnifera (W S) extract treatment might altered the functional integrity of testis and epididymis responsible to cause degenerative changes in these organs, responsible for reduction of fertility in W S treated rats.…”

Section: Discussionmentioning

confidence: 99%

“…Cholesterol is a steroid metabolite found in the cell membranes and transported in the blood plasma of animals. It is an essential structural component of mammalian cell membranes, an important component for the manufacture of bile acids, steroid hormones, and fat soluble vitamins 40,41 .The effect of W.somnifera on cholesterol is a reduction in cholesterol level of blood in diabetic W.somnifera treated group relative to diabetic control group has been observed 25 . Maytenus emargineta plant extracts also showed same effect on male albino rats 43 .…”

Section: Effect On Cholesterolmentioning

confidence: 98%

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2013

IJPSR

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Rapid rising population has caused serious problems in the economic growth and all around human development especially in developing countries like India. Our future well-being depends on increased access to family planning and reproductive health services and decreased consumption by people. Family planning has been promoted through several methods of contraception. But due to series adverse effects produced by synthetic steroidal contraceptives, attention has now been given to indigenous plants for possible contraceptive effects. Thus there is a need of replace these agents by plants. The investigation of plant constituents with development of an effective, reversible and safe male contraceptive represents a potential alternative approach to birth control from the existing available methods. This review concentrates on those recent advances in science and technology that offer possible inroads for shifting the paradigm for male-based contraception. This review presents updated information gathered on scientifically proved medicinal plant (Withania Somnifera) and their more than 50 secondary metabolites might be can use as male contraceptive agents and other biological activity. The aim of this review is to highlight the work on various plant drugs and their bioactive extracts involved in male antifertility mechanism.

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Section: Discussionmentioning

confidence: 99%

Section: Effect On Cholesterolmentioning

confidence: 98%

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2013

IJPSR

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“…Hence, one-five of this dose, i.e., up to 500 mg/kg body weight, was used for antifertility investigation. Hematological and biochemical parameters were also performed before and after treatment and no significant changes were observed [12][13][14][15][16].…”

Section: Acute Oral Toxicitymentioning

confidence: 99%

“…The reduced level of hormone may also be due to inactivation of luteinization of ovarian follicles, which could be responsible for the reduction in the concentration of serum progesterone in this study [14,[22][23][24][25][26][27][28]. An elevated level of progesterone during pregnancy plays a key role in maintaining the conditions and is an important factor in the implantation process.…”

Section: Hormonal Analysismentioning

confidence: 99%

Evaluate the Antifertility Potential of Ficus Racemosa Linn Bark in Female Wistar Rats

Shah¹

2016

Asian J Pharm Clin Res

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Objective: The present study was formulated to evaluate the antifertility potential of Ficus racemosa Linn bark on female Wistar rats.Methods: Effects of F. racemosa bark extract were studied on physicochemical parameters, successive solvent extraction, and phytochemical screening and antifertility activity. After acute oral toxicity study, antifertility activity in proven fertile female Wistar rats at the doses 500 mg/kg b.wt./day for 30 days. Effects on dimensions of the reproductive outcome, anti-implantation, abortifacient, estrogenic, and antiestrogenic activity were observed.Results: Phytochemical studies of F. racemosa bark shown a positive test for alkaloids, steroid, flavonoids, terpene, carbohydrates, and tannin. The extract of F. racemosa has the antifertility effect; the control rats showed a good number of litters. Treatment of animal with different extracts resulted a significant (p<0.05, p<0.01). Antifertility activity of 56.5% and 40.3% was exhibited by alcoholic F. racemosa extract (AFR) and aqueous F. racemosa Extract (WFR), respectively. After 21 days of the extract-free period, the antifertility effect of the extracts was reversed. The extract treatment with AFR, an increase in the percentage of resorption index indicates the failure in development of embryo. The mean percentage of anti-implantation and percent resorption (abortifacient) was found to be highest for AFR-41.21%, WFR 28.07, and AFR-32.56%, WFR-20.76%, respectively. The decrement in implantation caused by the extracts may be due to estrogenic or antiestrogenic activity. However, along with standard, AFR exhibiting more potent estrogenic and less potent antiestrogenic when compared with standard. Conclusion:The above results revealed the potential, reversible female antifertility effect of alcoholic extract F. racemosa bark.

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“…The number of litters was determined after the completion of one gestation period in all experimental groups. [15] The litters were allowed to grow and the growth of litters produced from the extractadministered group was compared with those of control group. The reversibility of antifertility effect of the extracts was also studied in the treated groups.…”

Section: Antifertility Studymentioning

confidence: 99%

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Shah

2016

IJGP

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Aim: The aim of this study was to investigate the antifertility activity of extracts of Piper betle petiole on female Wistar rats. Materials and Methods: Ethanolic and aqueous extract of petiole of P. betle was study antifertility activity in proven fertile female Wistar rats at the doses 500 mg/kg b.wt./day for 30 days. Different parameters were studied in female Wistar rats, including phytochemical, effect of the reproductive outcome, anti-implantation, abortifacient, and estrogenic and antiestrogenic activity, were observed. Results: P. betle showed positive test for alkaloids, steroids, flavonoids, terpenes, carbohydrates, and tannins. The extract of P. betle has antifertility effect the control rats showed good number of litters. Treatment of animal with different extracts resulted a significant (P < 0.05, P < 0.01). Antifertility activity 51% and 37.2% was exhibited by alcoholic extract P. betle (APB) and water extract P. betle (WPB), respectively. After 21 days of the extracts free period, the antifertility effect of the extracts was reversed. The extract treatment with APB, an increase in the percentage of resorption index indicates the failure in development of embryo. The mean percentage of anti-implantation and abortifacient was found to be highest for APB -38.45%, WPB -13.62%, and APB -28.96%, WPB -26.22%, respectively. The decrement in implantation caused by the extracts may be due to estrogenic or antiestrogenic activity. However, along with standard APB exhibiting more potent estrogenic and less potent antiestrogenic when compared with standard. Conclusion: Female antifertility agents should include acceptability, safety, and efficacy during and after the treatment. The above results revealed the potential, reversible female antifertility effect of APB.

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Effect of plumbagin free alcohol extract of Plumbago zeylanica Linn. root on reproductive system of female Wistar rats

Cited by 26 publications

References 11 publications

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Evaluate the Antifertility Potential of Ficus Racemosa Linn Bark in Female Wistar Rats

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