Effect of platelet‐rich plasma on orthodontic tooth movement in dogs

Abstract

Local injection of PRP in the present animal study resulted in accelerated orthodontic tooth movement with no obvious clinical or microscopic side effects.

Effect of platelet-rich plasma on the rate of orthodontic tooth movement:

“…20 Textor and Tablin 21 showed that calcium chloride activation might be the most inexpensive and effective method, although it might need 20 minutes for activation of PRP. 20 The injection technique in five different areas around the retracted canine followed the same protocol reported by Rashid et al 5 This may be compared with the findings of Gülec et al, 10 who injected the PRP only at the buccal vestibular mucosa adjacent to the mesial root of the first molar. Intraligamentary injection at the distobuccal and distopalatal surfaces of the canine root was advocated in this study based on the work by Von Böhl et al, 22,23 who reported that, as a consequence of local stress and shear concentrations, most hyalinized areas were not found in the area of the central plane but rather lingually and buccally from it.…”

“…24 Conversely, previous studies evaluating the effects of local pharmacologic agent injection to accelerate tooth movement reported only one or two submucosal or gingival injection sites. 4,10,[25][26][27] Injections were delivered every 3 weeks and repeated until the sixth week following the protocol reported by Rashid et al 5 Although the study continued for 4 months, injections were not continued through the whole duration of the study in order to determine whether PRP injections were enough in the initial phases of tooth movement only, as compared with corticotomy 12 or low-level laser therapy applications. 3 The results of the current study showed a faster rate of canine retraction on the intervention side in the first month by 15% and in the second month by 5%.…”

“…PRP was prepared by the double-spin technique as described by Marx and Garg 13 and Rashid et al 5 The intervention side was anesthetized with 2% mepivacaine with vasoconstrictor and left for 15 minutes. Then, 25 units (0.25 mL) of PRP was injected intraligamentally in the middle, distobuccal, and distopalatal areas of the distal surface of the canines (5 units each area) together with submucosal injections buccally and palatally (5 units each area).…”

“…One of the recently used local agents to accelerate the rate of orthodontic tooth movement is platelet-rich plasma (PRP). 5 PRP is defined as an autologous concentration of platelets in a minute volume of plasma. 6 The alpha granules in the platelets are the most abundant secretory granules.…”

“…9 The relationship between PRP and orthodontic tooth movement has drawn some attention lately. In two recently published animal studies, Rashid et al 5 and Gülec et al 10 evaluated the effects of PRP on tooth movement. Both studies showed a positive correlation between local injection of PRP and acceleration of orthodontic tooth movement.…”