Effect of Platelet-Rich Plasma on the Peri-implant Bone Response:

Fontana, Sebasti n; Olmedo, Daniel Gustavo; Linares, J.A.; Guglielmotti, Mar a Beatriz; Crosa, M

doi:10.1097/01.id.0000116455.68968.29

Cited by 59 publications

(58 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In rats, Fontana et al 34 (titanium laminar implant), Pryor et al 35 (collagen sponge) and Plachokova et al 36 (beta-tricalcium phosphate, hidroxiapatite) did not find results that justify the use of PRP. However, Weibrich et al 14 (implants) while studying different levels of PRP concentration, found positive results with concentrations lower than six times, and observed that the use of highly concentrated PRP (6-11 times) inhibits the bone repair.…”

Section: Discussionmentioning

confidence: 97%

Effects of a highly concentrated platelet-rich plasma on the bone repair using non-critical defects in the calvaria of rabbits

et al. 2010

View full text Add to dashboard Cite

PURPOSE: To verify the effect of highly concentrated platelet-rich plasma (hPRP) in the pathways of bone repair using non-critical defects in the calvaria of rabbits. METHODS: The hPRP was produced from collected venous blood of 21 rabbits. Four non-critical defects of 8 mm in diameter were created on the calvaria of each animal. The defects were all treated differently: autogenous particled bone (APB, group 1), autogenous particled bone associated with hPRP (APB + hPRP, group 2), isolated hPRP (group 3), and blood clot (control, group 4). Animals were submitted to euthanasia on the 2nd, 4th and 6th week postoperatively. Histological and histomorphometric analysis were carried through. RESULTS: After two weeks, groups 1 and 2 were in more advanced stage of repair than 3 and 4. At this period, comparing the groups 1 and 2, no significant differences were found between both, which also happened between the groups 3 and 4. However, after four and six weeks, the group 1 showed a more advanced stage of repair among all the other studied groups, while group 2 was in more advanced signs of bone repair than groups 3 and 4. Comparing groups 3 and 4, after four and six weeks, the least advanced stage of bone repair was found to be within group 3. CONCLUSION: The use of a highly concentrated PRP was considered prejudicial to the repair of non-critical defects in the calvaria of rabbits, either in the association of autogenous particled bone, when compared to autogenous particled bone alone, or in its isolated form, when compared to blood clot (control).

show abstract

Section: Discussionmentioning

confidence: 97%

Effects of a highly concentrated platelet-rich plasma on the bone repair using non-critical defects in the calvaria of rabbits

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Uma amostra do PRP foi separada para a contagem manual do número de plaquetas presentes. No momento da aplicação do enxerto ao leito receptor, adicionaram-se ao PRP e à hidroxiapatita 20% de tromboplastina cálcica c para a coagulação do PRP (FONTANA et al, 2004 ), VO, a cada 24 horas, durante sete dias.…”

Section: Methodsunclassified

Plasma rico em plaquetas combinado a hidroxiapatita na formação do calo ósseo em fraturas induzidas experimentalmente no rádio de cães

et al. 2007

View full text Add to dashboard Cite

show abstract

“…Preparation of platelets The washed platelets were prepared from platelet-rich plasma (PRP) by the single centrifuging and dilution procedure described by Fontana et al [10] . Briefly, blood was taken from the inferior caval vein of healthy rats not taking any medication, and directly added into 3.8% sodium citrate (1:9 v/v blood), followed by centrifugation at 250 r/min for 10 min.…”

Section: Methodsmentioning

confidence: 99%

Effect of curcumin on the adhesion of platelets to brain microvascular endothelial cellsin vitro¹

Zhang

Qin

et al. 2008

Acta Pharmacologica Sinica

View full text Add to dashboard Cite

Aim: To determine whether curcumin prevents the adhesion of platelets to brain microvascular endothelial cells (BMECs) cultured in vitro. Methods: [ 3 H]Adenine-labeled platelets were incubated with BMECs to investigate the role of curcumin in the adhesion of platelets to BMECs. The number of platelets adhering to the BMECs monolayer was determined by liquid scintillation spectroscopy. The thrombin-induced expression of platelets P-selectin, glycoprotein IIb (GPIIb), and glycoprotein IIIa (GPIIIa) on the cell surface, was measured by flow cytometry. P-selectin mRNA levels of BMECs were determined by RT-PCR. The TNF-α-induced expressions of P-selectin and E-selectin on the surface of BMECs were determined by Western blotting. Results: The adhesion between thrombin-activated platelets and normal BMECs, and that of TNF-α-activated BMECs and normal platelets were significantly increased, and this increase could be inhibited by curcumin (30-240 µmol/L) in a concentration-dependant manner. The platelets activated with thrombin and BMECs stimulated by TNF-α demonstrated an upregulated expressions of P-selectin and E-selectin, and this increase, when pretreated with curcumin for 30 min, could be restrained dose dependently. Curcumin also inhibited the increase of the GPIIb/GPIIIa expression of thrombinactivated platelets in a concentration-dependent manner. Conclusion: Curcumin can inhibit the platelets to BMECs. This effect may be related to the decreased expressions of P-selectin, E-selectin, and GPIIb/GPIIIa on platelets and BMECs.

show abstract

Effect of Platelet-Rich Plasma on the Peri-implant Bone Response:

Cited by 59 publications

References 18 publications

Effects of a highly concentrated platelet-rich plasma on the bone repair using non-critical defects in the calvaria of rabbits

Effects of a highly concentrated platelet-rich plasma on the bone repair using non-critical defects in the calvaria of rabbits

Plasma rico em plaquetas combinado a hidroxiapatita na formação do calo ósseo em fraturas induzidas experimentalmente no rádio de cães

Effect of curcumin on the adhesion of platelets to brain microvascular endothelial cellsin vitro¹

Contact Info

Product

Resources

About

Effect of Platelet-Rich Plasma on the Peri-implant Bone Response:

Cited by 59 publications

References 18 publications

Effects of a highly concentrated platelet-rich plasma on the bone repair using non-critical defects in the calvaria of rabbits

Effects of a highly concentrated platelet-rich plasma on the bone repair using non-critical defects in the calvaria of rabbits

Plasma rico em plaquetas combinado a hidroxiapatita na formação do calo ósseo em fraturas induzidas experimentalmente no rádio de cães

Effect of curcumin on the adhesion of platelets to brain microvascular endothelial cellsin vitro1

Contact Info

Product

Resources

About

Effect of curcumin on the adhesion of platelets to brain microvascular endothelial cellsin vitro¹