Effect of Platelet-Rich Fibrin on Peripheral Nerve Regeneration

Şenses, Fatma; Önder, M. Ercüment; Koçyiğit, İsmail; Kul, Oğuz; Aydın, Gülümser; İnal, Elem; Atıl, Fethi; Tekin, Umut

doi:10.1097/scs.0000000000003066

Cited by 19 publications

(14 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A total of 2 ml venous blood was drawn from the caudal vein of rats used in the experiment into a plain tube and immediately centrifuged at room temperature with a lab centrifuge (Electronic centrifuge 800, China) for 10 min at 3000 rpm 20 . In the middle of the tube, a fibrin clot was formed between the supernatant acellular plasma and the lower red corpuscles.…”

Section: Methodsmentioning

confidence: 99%

Healing capacity of bone marrow mesenchymal stem cells versus platelet-rich fibrin in tibial bone defects of albino rats: an in vivo study

2018

View full text Add to dashboard Cite

Background: Various techniques for tissue engineering have been introduced to aid the regeneration of defective or lost bone tissue. The aim of this study was to compare the in vivo bone-forming potential of bone marrow mesenchymal stem cells (BM-MSCs) and platelet-rich fibrin (PRF) on induced bone defects in rats’ tibiae. Methods: In total, one defect of 3-mm diameter was created in each tibia of 36 Wistar male rats. There were two groups: group A, left tibia bone defects that received PRF; and group B, right tibia bone defects of the same animal that received BM-MSCs loaded on a chitosan scaffold. Subsequently, Scanning electron microscope/energy-dispersive X-ray (SEM/EDX) analyses was performed at 3 and 10 days, and 3 weeks post‑implantation and following euthanasia; (n=12). Results: The EDX analysis performed for each group and time point revealed a significant increase in the mean calcium and phosphorous weight percentage in the BM-MSC-treated group relative to the PRF-treated group at all-time intervals (P < 0.05). Moreover, the mean calcium and phosphorus weight percentage increased as time progressed since the surgical intervention in the PRF-treated and BM-MSCs groups (P < 0.05). Conclusions: In the present study, both BM-MSCs and PRF were capable of healing osseous defects induced in a rat tibial model. Yet, BM-MSCs promoted more adequate healing, with higher mean calcium and phosphorous weight percentages than PRF at all-time points, and showed greater integration into the surrounding tissues than PRF.

show abstract

Section: Methodsmentioning

confidence: 99%

Healing capacity of bone marrow mesenchymal stem cells versus platelet-rich fibrin in tibial bone defects of albino rats: an in vivo study

2018

View full text Add to dashboard Cite

show abstract

“…Axon regeneration through conduits can be increased compared to that through empty collagen conduits by modifying their composition, architectures, and the factors/cells they contain. However, no conduit tested is as effective as allografts in inducing axon regeneration across both short and long gaps [55,68,204] under nerve injury conditions that are common clinically, such as a long gap in older patients that must be repaired at a long time post-trauma. An additional challenge is that the conduits that are most effective in animal models cannot be used clinically.…”

Section: Conclusion For Conduitsmentioning

confidence: 99%

Restoration of Neurological Function Following Peripheral Nerve Trauma

Kuffler

Foy

2020

IJMS

View full text Add to dashboard Cite

Following peripheral nerve trauma that damages a length of the nerve, recovery of function is generally limited. This is because no material tested for bridging nerve gaps promotes good axon regeneration across the gap under conditions associated with common nerve traumas. While many materials have been tested, sensory nerve grafts remain the clinical “gold standard” technique. This is despite the significant limitations in the conditions under which they restore function. Thus, they induce reliable and good recovery only for patients < 25 years old, when gaps are <2 cm in length, and when repairs are performed <2–3 months post trauma. Repairs performed when these values are larger result in a precipitous decrease in neurological recovery. Further, when patients have more than one parameter larger than these values, there is normally no functional recovery. Clinically, there has been little progress in developing new techniques that increase the level of functional recovery following peripheral nerve injury. This paper examines the efficacies and limitations of sensory nerve grafts and various other techniques used to induce functional neurological recovery, and how these might be improved to induce more extensive functional recovery. It also discusses preliminary data from the clinical application of a novel technique that restores neurological function across long nerve gaps, when repairs are performed at long times post-trauma, and in older patients, even under all three of these conditions. Thus, it appears that function can be restored under conditions where sensory nerve grafts are not effective.

show abstract

“…68 In contrast, PRF failed to increase functional recovery in a 5-mm sciatic nerve gap as shown by functional, histopathologic and electrophysiologic analyses. 87 Although the PRF in these two studies was produced using the same protocol described by Choukroun et al , 23 the effective concentrations of activated platelets and released growth factors were not examined in the latter study, making it almost impossible to know whether the observed differences were due to inter-individual variation or the preparation method.…”

Section: Prp Treatment: Preparation and Biological Characteristicsmentioning

confidence: 99%

Platelet-rich plasma for regeneration of neural feedback pathways around dental implants: a concise review and outlook on future possibilities

et al. 2017

View full text Add to dashboard Cite

Along with the development of new materials, advanced medical imaging and surgical techniques, osseointegrated dental implants are considered a successful and constantly evolving treatment modality for the replacement of missing teeth in patients with complete or partial edentulism. The importance of restoring the peripheral neural feedback pathway and thus repairing the lack of periodontal mechanoreceptors after tooth extraction has been highlighted in the literature. Nevertheless, regenerating the nerve fibers and reconstructing the neural feedback pathways around osseointegrated implants remain a challenge. Recent studies have provided evidence that platelet-rich plasma (PRP) therapy is a promising treatment for musculoskeletal injuries. Because of its high biological safety, convenience and usability, PRP therapy has gradually gained popularity in the clinical field. Although much remains to be learned, the growth factors from PRP might play key roles in peripheral nerve repair mechanisms. This review presents known growth factors contributing to the biological efficacy of PRP and illustrates basic and (pre-)clinical evidence regarding the use of PRP and its relevant products in peripheral nerve regeneration. In addition, the potential of local application of PRP for structural and functional recovery of injured peripheral nerves around dental implants is discussed.

show abstract

Effect of Platelet-Rich Fibrin on Peripheral Nerve Regeneration

Abstract: The study results suggest that PRF decreases functional recovery in sciatic nerve injury. Further studies are required to determine the efficacy of PRF on peripheral nerve regeneration.

Cited by 19 publications

References 47 publications

Healing capacity of bone marrow mesenchymal stem cells versus platelet-rich fibrin in tibial bone defects of albino rats: an in vivo study

Healing capacity of bone marrow mesenchymal stem cells versus platelet-rich fibrin in tibial bone defects of albino rats: an in vivo study

Restoration of Neurological Function Following Peripheral Nerve Trauma

Platelet-rich plasma for regeneration of neural feedback pathways around dental implants: a concise review and outlook on future possibilities

Contact Info

Product

Resources

About