Effect of Plasma Mebendazole Concentrations in the Treatment of Human Echinococcosis

Woodtli, W; Bircher, J; Witassek, F; Eckert, Johannes; Wüthrich, B; Ammann, Rudolf W.

doi:10.4269/ajtmh.1985.34.754

Cited by 38 publications

(14 citation statements)

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“…The concentrations we used were in the range of therapeutic achievable levels (24,25). A study by Woodtli and colleagues revealed that plasma levels of 0.30 mmol/L mebendazole are the optimal therapeutic levels for treatment of inoperable echinococcosis (26). In our studies, the similar concentration of 0.25 mmol/L mebendazole induced apoptosis shown by nuclear fragmentation in 65% of the multiple myeloma cells (Fig.…”

Section: Discussionsupporting

confidence: 55%

Targeting the Microtubular Network as a New Antimyeloma Strategy

Feng

Liu

et al. 2011

Molecular Cancer Therapeutics

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We identified nocodazole as a potent antimyeloma drug from a drug screening library provided by the Multiple Myeloma Research Foundation. Nocodazole is a benzimidazole that was originally categorized as a broad-spectrum anthelmintic drug with antineoplastic properties. We found that nocodazole inhibited growth and induced apoptosis of primary and multiresistant multiple myeloma cells cultured alone and in the presence of bone marrow stromal cells. Nocodazole caused cell-cycle prophase and prometaphase arrest accompanied by microtubular network disarray. Signaling studies indicated that increased expression of Bim protein and reduced X-linked inhibitor of apoptosis protein and Mcl-1 L levels were involved in nocodazole-induced apoptosis. Further investigation showed Bcl-2 phosphorylation as a critical mediator of cell death, triggered by the activation of c-jun-NH 2 kinase (JNK) instead of p38 kinase or extracellular signalregulated kinases. Treatment with JNK inhibitor decreased Bcl-2 phosphorylation and subsequently reduced nocodazole-induced cell death. Nocodazole combined with dexamethasone significantly inhibited myeloma tumor growth and prolonged survival in a human xenograft mouse model. Our studies show that nocodazole has potent antimyeloma activity and that targeting the microtubular network might be a promising new treatment approach for multiple myeloma. Mol Cancer Ther; 10(10); 1886-96. Ó2011 AACR.

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Section: Discussionsupporting

confidence: 55%

Targeting the Microtubular Network as a New Antimyeloma Strategy

Feng

Liu

et al. 2011

Molecular Cancer Therapeutics

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“…The diagnosis of alveolar echinococcosis-had been confirmed clinically, histologically and serologically (WOODTLI et al, 1985;AMMANN et al ., 1989). All patients had received surgical treatment with subsequent long-term mebendazole chemotherapy (for details see AMMANN et al, 1989).…”

Section: Patientsmentioning

confidence: 93%

Em2-ELISA for the follow-up of alveolar echinococcosis after complete surgical resection of liver lesions

Gottstein

Tschudi

Eckert

et al. 1989

Transactions of the Royal Society of Tropical Medicine and Hygi

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Alveolar echinococcosis, a serious and often fatal human disease, can be efficiently cured only by complete surgical resection of the Echinococcus multilocularis lesion. The present study showed that the determination in patients who had undergone surgery of antibody activity directed against the antigen Em2 reliably reflected complete or incomplete surgical resection. From 9 patients with pre-operative positive results in the Em2 enzyme-linked immunosorbent assay (Em2-ELISA) and successful surgical resection, 6 converted to negative within one year and the remaining 3 patients within 4 years after surgery. Six of 7 additional patients who showed recurrences in an average of 6 years after surgery despite assumed complete surgical resection, were positive by Em2-ELISA at the time of recurrence. Discrimination was not possible between these 2 groups of patients when using an ELISA employing crude antigen obtained from E. granulosus hydatid cyst fluid.

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“…In contrast to previous reports, patients were not selected based on clinical signs and symptoms that suggested IVC obstruction but were selected on the basis of repeated CT scans in a large series of patients prospectively followed up because of AE. 10 One of the most striking findings of our study was the low rate of signs and symptoms of chronic venous insufficiency. The finding is remarkable since edema of Table).…”

Section: Commentmentioning

confidence: 78%

“…The protocol of the study has been published. 10 Briefly, patients were examined at yearly intervals. Control studies included a physical examination, routine laboratory tests, a chest radiograph, and ultrasonography and CT scan of the abdomen.…”

Section: Methodsmentioning

confidence: 99%