Effect of plant sterols and glucomannan on lipids in individuals with and without type II diabetes

Yoshida, Makiko; Vanstone, Catherine A.; Parsons, William D.; Zawistowski, Jerzy; Jones, Peter J.H.

doi:10.1038/sj.ejcn.1602347

Cited by 72 publications

(72 citation statements)

References 26 publications

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“…Two pertinent dietary changes with a high level of compliance could result in substantial cholesterol lowering. There is a limited number of studies in the literature where changes have been made to two discrete cholesterol-lowering components, without significant manipulation of the background diet, and where the effect of each has been quantified separately and as a combination, necessary to establish the extent of synergy between the agents; see, for example, Theuwissen & Mensink (103) and Yoshida et al (107) . In a further study the effects of oats and soya protein were assessed independently and together, but after all subjects had complied with the macronutrient targets of an American Heart Association step 1 diet for 3 weeks (108) .…”

Section: Simple Food Combinationsmentioning

confidence: 99%

“…Study duration was relatively short and varied between 3 weeks and 3 months. Three studies used plant stanol or sterolsoluble fibre combinations (103,107,112) , of which two determined the effect of the individual components, as well as the combination (103,107) .…”

Section: Simple Food Combinationsmentioning

confidence: 99%

“…A study in which a glucomannan -plant sterol combination was used also provides an insight to the mechanisms involved. In this study plasma lathosterol, a cholesterol precursor and an index of cholesterol synthesis, was determined (107) . Plasma lathosterol concentrations were increased from baseline with plant sterol treatment, but not with glucomannan supplementation; furthermore the glucomannan -plant sterol combination resulted in decreased plasma lathosterol (P, 0·05), suggesting that glucomannan suppresses the compensatory increase of cholesterol synthesis by plant sterol intake (107) .…”

Section: Simple Food Combinationsmentioning

confidence: 99%

“…In this study plasma lathosterol, a cholesterol precursor and an index of cholesterol synthesis, was determined (107) . Plasma lathosterol concentrations were increased from baseline with plant sterol treatment, but not with glucomannan supplementation; furthermore the glucomannan -plant sterol combination resulted in decreased plasma lathosterol (P, 0·05), suggesting that glucomannan suppresses the compensatory increase of cholesterol synthesis by plant sterol intake (107) . In a study where mildly hypercholesterolaemic subjects consumed b-glucan with or without plant stanol esters, there was no significant effect on inflammatory parameters, nor were there changes in expression profiles of eighty-four genes involved in atherosclerosis metabolism when Food combinations for cholesterol lowering b-glucan was included in the diet and the expression of only three genes -ADFP (adipose differentiation-related protein), CDH5 (cadherin 5, type 2) and CSF2 (granulocyte-macrophage colony-stimulating factor 2) -changed after plant stanol ester consumption (113) .…”

Section: Simple Food Combinationsmentioning

confidence: 99%

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Food combinations for cholesterol lowering

Harland

2012

Nutr. Res. Rev.

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Reducing elevated LDL-cholesterol is a key public health challenge. There is substantial evidence from randomised controlled trials (RCT) that a number of foods and food components can significantly reduce LDL-cholesterol. Data from RCT have been reviewed to determine whether effects are additive when two or more of these components are consumed together. Typically components, such as plant stanols and sterols, soya protein, b-glucans and tree nuts, when consumed individually at their target rate, reduce LDL-cholesterol by 3 -9 %. Improved dietary fat quality, achieved by replacing SFA with unsaturated fat, reduces LDL-cholesterol and can increase HDL-cholesterol, further improving blood lipid profile. It appears that the effect of combining these interventions is largely additive; however, compliance with multiple changes may reduce over time. Food combinations used in ten 'portfolio diet' studies have been reviewed. In clinical efficacy studies of about 1 month where all foods were provided, LDL-cholesterol is reduced by 22-30 %, whereas in community-based studies of .6 months' duration, where dietary advice is the basis of the intervention, reduction in LDL-cholesterol is about 15 %. Inclusion of MUFA into 'portfolio diets' increases HDL-cholesterol, in addition to LDL-cholesterol effects. Compliance with some of these dietary changes can be achieved more easily compared with others. By careful food component selection, appropriate to the individual, the effect of including only two components in the diet with good compliance could be a sustainable 10 % reduction in LDL-cholesterol; this is sufficient to make a substantial impact on cholesterol management and reduce the need for pharmaceutical intervention.

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Section: Simple Food Combinationsmentioning

confidence: 99%

Section: Simple Food Combinationsmentioning

confidence: 99%

Section: Simple Food Combinationsmentioning

confidence: 99%

Section: Simple Food Combinationsmentioning

confidence: 99%

See 2 more Smart Citations

Food combinations for cholesterol lowering

Harland

2012

Nutr. Res. Rev.

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“…In addition to improving blood lipid profile, glocomanan can also improve glycemic control and cystole blood pressure [13]. And combination of glucomannan and sterol substantially can improve the low-density lipoprotein cholesterol (LDL) as well [15]. Time-point measurement of blood LDLcholesterol LDL-cholesterol were measured using blood serum at day 11 (before the cholesterol diet, cholesterol diet start at day 12), 35 (before diet Amorphophallus, the diet begins day 38), 49, and 63.…”

Section: Introductionmentioning

confidence: 99%

Effect of Dietary Amorphophallus sp From East Java on LDL-C Rats (Rattus novergicus Wistar Strain)

Harijati¹,

Widyarti²,

Azrianingsih³

2012

JTLS

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One of indication of obesity is high LDL-C . Obesity has serious risk to health, it can cause heart disease and stroke. Effort to lower obesity using drugs have significant side effects such as insomnia, increased blood pressure, dry mouth and so forth. Therefore using natural products that contain glucomannan to reduce obesity and LDL-C is good choise. Glucomannan in the global market derived from Amorphophallus konjac. In this study, we used glucomannan from Amorphophallus endemic East Java to reduce fattened Wistar rats. Amorphophallus that used include Amorphophallus muelleri, A.variabilis (variant: Brongkos 32; Brongkos 5; Wonorejo, Brangsi) and Amorphophallus campanulatus (Var Selopuro). Amorphophallus diet was given to white rats of Wistar strain that previously fattened using a mixture of cholesterol and lard, in addition to PARS (Chicken Feed Race Super) as a basic food. Amorphophallus konjac was used as control. Measurement of LDL-C was conducted in four different time points, namely 1). Prior to dietary cholesterol, 2). 24 days after the dietary cholesterol, 3) 11 days after Amorphophallus (+cholesterol) diet, 4). 25 days after Amorphophallus (+cholesterol) diet. The results showed that the diet of A.variabilis potentially lowered blood cholesterol levels for their respective 22.98%, 5.85% and 7.37% for consecutive variant Brongkos 32; Brongkos 5; Wonorejo. Diet from A.campanulatus and A.konjac had not been able to reduce cholesterol to the end of observation (25 days).

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Konjac Glucomannan

Parry

2009

Food Stabilisers, Thickeners and Gelling Agents

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Effect of plant sterols and glucomannan on lipids in individuals with and without type II diabetes

Cited by 72 publications

References 26 publications

Food combinations for cholesterol lowering

Food combinations for cholesterol lowering

Effect of Dietary Amorphophallus sp From East Java on LDL-C Rats (Rattus novergicus Wistar Strain)

Konjac Glucomannan

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