Effect of Plant Seeds Peganum harmala Evaporation on Fertility of White Rats Male Treated with Drug Chlorpromazine

Al-Mushhadani, Thaer M.; Arteen, Hussian E.; Jumaa, Hamad J.

doi:10.33899/rjs.2014.88652

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar observations were reported by El-Dwairi and Banihani [ 22 ] in rats treated for 60 days with P. harmala seeds extract. In another study, the research team members concluded that the evaporation of P. harmala seeds for 7, 14, and 21 days, respectively, caused an increased sperm count in male rats treated with chloropromazine [ 47 ]. Likewise, the in vitro addition of low concentrations of total alkaloids P. harmala seeds in the sperm produced stimulation of motility and protection against oxidative damages [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Peganum harmala Total Alkaloid Extract on Sexual Behavior and Sperm Parameters in Male Mice

Derbak,

Imre,

Benabdelhak

et al. 2023

Veterinary Sciences

View full text Add to dashboard Cite

The study was designed to evaluate the effects of the total alkaloid extract of Algerian Peganum harmala seeds on sexual behavior and male reproductive function. After two weeks of acclimatization, the male mice were randomly divided into four groups (seven mice in each group). For 35 days, the extract was administered orally at dose levels of 6.25, 12.5, and 25 mg/kg body weight per day to the respective groups of male mice (n = 7) and normal saline daily to the control group. On day 28, sexual behavior parameters were recorded. At the end of the trial, reproductive organ weights, sperm quality, seminal fructose, and testosterone hormone levels were evaluated. The three treated groups were compared with the control using statistical variance analysis (one-way ANOVA, p < 0.05), followed by Tukey’s test. The results of the groups treated with 12.5 and 6.25 mg/kg of P. harmala alkaloid revealed the MF and IF parameters to be the lowest compared to the control group (p < 0.05). However, the male mice treated with 25 mg/kg recorded the highest values. A low significant value of ML was observed in the group treated with 25 mg/kg of the total alkaloid extract of P. harmala compared to the control group (p < 0.01), while a rise was observed in the concentration group treated with 6.25 mg/kg. Regarding IL, the male mice treated with different concentrations of the total alkaloid extract of P. harmala recorded a higher time than the control group. Moreover, an increase in the gonadosomatic index was noticed in all groups compared to the control group. However, there was a significant (p < 0.01) decrease in the sperm counts of the groups treated with 12.5 mg/kg and 6.25 mg/kg. However, there was no significant difference in the motility, membrane integrity, and total antioxidant capacity of sperm cells compared to the control. The extract treatment also brought about a non-significant increase in fructose content of the seminal vesicle and serum testosterone level. The findings of this study demonstrate that the extract acts in a dose-dependent manner, and it has varying effects on the reproductive parameters of male mice.

show abstract

Section: Discussionmentioning

confidence: 99%