Effect of pituitary adenylate cyclase-activating polypeptide on exocrine and endocrine secretion in the ovine pancreas

Onaga, Takenori; Uchida, Megumi; Kimura, Masashi; Miyazaki, M; Hashiguchi, Mineo; Kato, Shinichi; Zabielski, R.

doi:10.1016/s0742-8413(96)00078-3

Cited by 5 publications

(5 citation statements)

References 30 publications

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“…In the rabbit pancreas, PACAP-27 stimulated amylase release (162). Similar stimulatory effects were noted in other species and ascribed to a cholinergic mechanism of action (137,146,147,217). A direct effect of PACAP on the isolated guinea pig acinar cell has also been demonstrated, and CCK was found to have a synergistic effect (82).…”

Section: Pancreatic Hormones and Neuropeptidesmentioning

confidence: 57%

The islet-acinar axis of the pancreas: more than just insulin

Barreto

Carati

Toouli³

et al. 2010

American Journal of Physiology-Gastrointestinal and Liver Physi

103

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Although the role of the islets in the regulation of acinar cell function seemed a mystery to investigators who observed their dispersion among pancreatic acini, over time an appreciation for this intricate and unique structural arrangement has developed. The last three decades have witnessed a steadily growing understanding of the interrelationship of the endocrine and the exocrine pancreas. The islet innervation and vascular anatomy have been more fully characterized and provide an appropriate background for our current understanding. The interrelationship between the endocrine and exocrine pancreas is mediated by islet-derived hormones such as insulin and somatostatin, other humoral factors including pancreastatin and ghrelin, and also neurotransmitters (nitric oxide, peptide YY, substance P, and galanin) released by the nerves innervating the pancreas. Although considerable progress has been achieved, further work is required to fully delineate the complex interplay of the numerous mechanisms involved. This review aims to provide a comprehensive update of the current literature available, bringing together data gleaned from studies addressing the actions of individual hormones, humoral factors, and neurotransmitters on the regulation of amylase secretion from the acinar cell. This comprehensive view of the islet-acinar axis of the pancreas while acknowledging the dominant role played by insulin and somatostatin on exocrine secretion sheds light on the influence of the various neuropeptides on amylase secretion.

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Section: Pancreatic Hormones and Neuropeptidesmentioning

confidence: 57%

The islet-acinar axis of the pancreas: more than just insulin

Barreto

Carati

Toouli³

et al. 2010

American Journal of Physiology-Gastrointestinal and Liver Physi

103

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“…Intravenous injection of PACAP triggers amylase (Mungan et al, 1991;Alonso et al, 1994), pancreatic fluid, bicarbonate, and protein secretions (Naruse et al, 1992;Alonso et al, 1994;Zabielski et al, 1994;Rodríguez-López et al, 1995;Onaga et al, 1996;Wheeler et al, 1997;Lee et al, 1998;Glad et al, 2003). PACAP also induces vasodilation and increases pancreatic blood flow, notably in the exocrine part of the gland (Carlsson et al, 1996;Ito et al, 1998).…”

Section: H Effects Of Pituitary Adenylate Cyclase-activating Polypepmentioning

confidence: 99%

Pituitary Adenylate Cyclase-Activating Polypeptide and Its Receptors: 20 Years after the Discovery

et al. 2009

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“…dose-dependent manner, and the effect of PACAP-27 was more potent when compared to PACAP-38 (Onaga et al 1996). In the latter study it has been also shown that intravenous infusion of PACAP-38 (no data concerning PACAP-27 are available) did not influence the plasma concentration of insulin, glucagon and glucose (Onaga et al 1996) what indicates no effect of PACAP-38 on the ovine endocrine pancreas activity.…”

Section: Discussionmentioning

confidence: 72%

“…In the latter study it has been also shown that intravenous infusion of PACAP-38 (no data concerning PACAP-27 are available) did not influence the plasma concentration of insulin, glucagon and glucose (Onaga et al 1996) what indicates no effect of PACAP-38 on the ovine endocrine pancreas activity. The role of both PACAP-27 and PACAP-38 in the regulation of the pancreatic blood flow has been also experimentally determined in several animal species (Naruse et al 1998, Yamaguchi et al 2003.…”

Section: Discussionmentioning

confidence: 87%

Pituitary adenylate cyclase-activating peptide-27 (PACAP-27) is co-stored with galanin, substance P and corticotropin releasing factor (CRF) in intrapancreatic ganglia of the sheep

Arciszewski¹,

Mozel²,

Sienkiewicz³

2015

Polish Journal of Veterinary Sciences

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Pituitary adenylate cyclase activating polypeptide (PACAP) is a neuropeptide existing in two variant forms (of either 27 or 38 residues), widely present in numerous organs and evoking multiple effects both in the central and peripheral nervous systems. The present study was undertaken to evaluate the distribution pattern of PACAP-27 expression in the ovine pancreas. Using double immunohistochemical stainings co-localizations of PACAP-27 with galanin, SP or CRF were studied in intrapancreatic neurons. In intrapancreatic ganglia, immunoreactivty to PACAP-27 was found in 87.6 ± 5.4% of PGP 9.5-positive intrapancreatic neurons but not in intraganglionic nerve fibres. Numerous PACAP-27-immunoreactive nerve terminals were also observed between pancreatic acini and around small arterioles. No immunoreactivity to PACAP-27 was found in the endocrine pancreas. In 42.9 ± 6.2% of PACAP-27-immunoreactive intrapancreatic neurons the expression of galanin was also found. Statistically lower subpopulation (12.4 ± 4.0%) of intrapancreatic neurons exhibited simultaneously the immunoreactivity to PACAP-27 and SP. The expression of CRF was detected in the relatively smallest group (3.2 ± 1.4%) of PACAP-27-positive intrapancreatic neurons. The present results suggest that in the ovine pancreas PACAP-27 may play an important role as mediator of pancreatic functions. In PACAP-related pancreatic activities, a modulatory role of galanin, SP and to a lower extend of CRF is also likely.

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Effect of pituitary adenylate cyclase-activating polypeptide on exocrine and endocrine secretion in the ovine pancreas

Cited by 5 publications

References 30 publications

The islet-acinar axis of the pancreas: more than just insulin

The islet-acinar axis of the pancreas: more than just insulin

Pituitary Adenylate Cyclase-Activating Polypeptide and Its Receptors: 20 Years after the Discovery

Pituitary adenylate cyclase-activating peptide-27 (PACAP-27) is co-stored with galanin, substance P and corticotropin releasing factor (CRF) in intrapancreatic ganglia of the sheep

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