Effect of piroxicam treatment on pregnancy rate in intracytoplasmic sperm injection (ICSI)

Asgharnia, M; Mehrafza, Marzieh; Oudi, M; Hoseeieni, A.

doi:10.1016/j.fertnstert.2007.07.553

Cited by 3 publications

(3 citation statements)

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“…Both the Dal Prato and Borini (2009) and Bernabeu et al (2006) studies used vaginal progesterone as luteal support for all participants, while Moon et al (2004) and Firouzabadi et al (2007) did not. Still, Asgharnia et al (2007) and Sohrabvand et al (2009) did not mention progesterone either and still did not show a significant difference with the control group. Studies of the prostaglandin synthetase inhibitor aspirin (acetylsalicylic acid) have shown slight improvement in implantation and pregnancy rates.…”

Section: Treatment Optionsmentioning

confidence: 90%

“…Moon et al (2004) found that the administration of the prostaglandin inhibitor piroxicam before ET increased both the implantation rate (18.7% versus 8.7%) and pregnancy rate (46.8% versus 27.6%), when compared with a placebo control group, as did Firouzabadi et al (2007). By contrast, four other studies did not find a positive effect on success rates (for implantation or pregnancy) using either piroxicam or indomethacin (Asgharnia et al, 2007;Bernabeu et al, 2006;Dal Prato and Borini, 2009;Sohrabvand et al, 2009). Dal Prato and Borini (2009) suggested that these results differ due to the additional use of progesterone as luteal support.…”

Section: Treatment Optionsmentioning

confidence: 91%

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Uterine peristalsis and fertility: current knowledge and future perspectives: a review and meta-analysis

Kuijsters

Methorst

Kortenhorst

et al. 2017

Reproductive BioMedicine Online

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Although uterine contractions in the non-pregnant uterus have been studied extensively, the knowledge gained has not been used in general fertility treatment work-up. In this review paper, we provide an overview of the current knowledge on uterine peristalsis (UP), based on the available literature. This literature shows that UP influences pregnancy chances in both natural and artificial cycles. Although the physiological background of these contractions is not completely clear, we know that several factors can be of influence, like uterine pathologies and hormones. Several options to alter pregnancy outcome by interfering with uterine contractions have been studied. Our meta-analysis on therapeutic options shows positive results of progesterone at time of embryo transfer in IVF cycles or prostaglandins at time of intrauterine insemination, although the quality of evidence is low. These therapies are probably most beneficial in selected groups of patients with abnormal contraction patterns. The introduction of an objective and user-friendly UP measuring tool suitable for use in daily practice would make it possible to identify and monitor these patients. We suggest that future research should focus on the physiology of initiation of UP and on the development of an effective standard measuring tool.

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Section: Treatment Optionsmentioning

confidence: 90%

Section: Treatment Optionsmentioning

confidence: 91%

Uterine peristalsis and fertility: current knowledge and future perspectives: a review and meta-analysis

Kuijsters

Methorst

Kortenhorst

et al. 2017

Reproductive BioMedicine Online

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show abstract

“…Four studies investigated the use of beta adrenergic receptors agonists (Hanevik et al, 2012;Pinheiro et al, 2003;Rabiee et al, 2011;Tsirigotis et al, 2000). Seven studies investigated the use of prostaglandin synthetase inhibitors (Asgharnia et al, 2007;Bernabeu et al, 2006;Dal Prato and Borini, 2009;Firouzabadi et al, 2007;Moon et al, 2004;Sohrabvand et al, 2009Sohrabvand et al, , 2014.…”

Section: Resultsmentioning

confidence: 99%

The effect of peri-implantation administration of uterine relaxing agents in assisted reproduction treatment cycles: a systematic review and meta-analysis

Khairy

Dhillon

Chu

et al. 2016

Reproductive BioMedicine Online

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Sub-endometrial junctional zone peristalsis is increased by ovarian stimulation and traumatic embryo transfer, and is linked with decreased implantation and pregnancy rates in assisted reproduction treatments. Various agents have been used to inhibit uterine hyper-peristalsis at the time of embryo transfer with conflicting results. This systematic review aimed to identify if uterine relaxants administered in the peri-implantation period during assisted reproduction treatments could improve pregnancy outcomes through literature search with no language restrictions. The review reports on 3546 patients in 17 randomized controlled trials published between 1993 and 2014. Women undergoing assisted reproduction techniques who either received a uterine relaxant agent in the peri-implantation period versus placebo or no treatment were included. Primary outcome was live birth rate. The meta-analyses did not show statistically significant benefit of any uterine relaxing agents on live birth rate. Other meta-analyses did not show a significant effect on the clinical pregnancy, spontaneous abortion, ectopic pregnancy and multiple pregnancy rate. Most of the included studies were of low quality and lacked significant power to detect minimally important effect. Evidence is insufficient to recommend using these agents in routine practice. Further methodologically robust randomized controlled trials with more refined selection criteria might reveal a beneficial effect.

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Nonsteroidal anti-inflammatory drugs for assisted reproductive technology

Nyachieo

Siristatidis

Vaidakis³

2019

Cochrane Database of Systematic Reviews

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Effect of piroxicam treatment on pregnancy rate in intracytoplasmic sperm injection (ICSI)

Cited by 3 publications

References 0 publications

Uterine peristalsis and fertility: current knowledge and future perspectives: a review and meta-analysis

Uterine peristalsis and fertility: current knowledge and future perspectives: a review and meta-analysis

The effect of peri-implantation administration of uterine relaxing agents in assisted reproduction treatment cycles: a systematic review and meta-analysis

Nonsteroidal anti-inflammatory drugs for assisted reproductive technology

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