Effect of Piroxicam and/or Ascorbic Acid on Postoperative Pain in Orchidectomised Goats

Abstract

The study evaluates effects of varied doses of ascorbic acid and piroxicam on behavioural signs of pain in orchidectomised Savannah Brown goats during their postsurgical pain management. The goats were divided into 6 groups of 3 goats each. Orchidectomy was performed on all animals under sedation with xylazine and linear infiltration with lignocaine. After surgery, varied doses of piroxicam (IM) and ascorbic acid (IV) were administered to the goats: Group A = piroxicam, 5 mg/kg + ascorbic acid, 100 mg/kg; Group B = piroxicam, 5 mg/kg + ascorbic acid, 200 mg/kg; Group C = piroxicam, 10 mg/kg + ascorbic acid, 100 mg/kg; Group D = piroxicam, 5 mg/kg; Group E: ascorbic acid, 100 mg/kg together with antibiotics, procaine penicillin, 20,000 IU/kg + streptomycin, 10 mg/kg (IM); and Group F (control) received only the antibiotics. After surgery, pain intensity was determined in each goat by numerical rating scale. Vocalisation, teeth grinding, rapid and shallow breathing, tail wagging, occasionally bleating, neck extension, and dorsal lip curling were recorded at varying degrees across the experimental groups. The goats in the control group showed the highest degree of behavioural signs of pain. It is concluded that treatment with a combination of piroxicam and ascorbic acid ameliorated pain more than either of the agents in orchidectomised Savannah Brown goats.

Hematological prediction study of peritonitis following laparotomy in goats

“…The surgical sites were dressed using povidone iodine (Wosan ® , Jawa International Limited, Lagos, Nigeria). Postoperative antibiotic was not administered to any of the animals; however, piroxicam (Yanzhou Xier Kangtai Pharmaceutical, Yanzhou, China) was administered as an analgesic at 5 mg/kg intramuscularly for 3 days post-surgery [22].…”

Effect of Joint Inflammation on Piroxicam Pharmacokinetics in Rats

“…Piroxicam is a nonsteroidal anti-inflammatory drug of the oxicam class used to relieve the symptoms of painful, inflammatory conditions like arthritis, surgery, cancers in dogs and cats [1], horse [2] andgoats [3], as well as mastitis in goat and cattle [4]. Piroxicam hasantipyretic, anti-inflammatoryand analgesic properties with advantage of once-a-day dosing and so can be used for acute or long term therapy of arthritis.…”