Effect of Pirenoxine Ophthalmic Solution on Senile Incipient Cataract in Dogs

Asakura, Soichiro; Ohta, Mitsuharu; Takimoto, Yoshiyuki; Hara, Kikuji; Nishi, Masaru

doi:10.12935/jvma1951.46.952

Cited by 2 publications

(8 citation statements)

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“…Eye drops containing antioxidants, as well as oral antioxidants, have been widely used in humans and dogs. Pirenoxine antioxidant eye drops were reported to suppress the progression of presbyopia in rats and also reduce lens opacity and delayed cataract progression in dogs [ 26 27 28 ]. Additionally, the instillation of eye drops containing N-acetyl carnosine, another antioxidant, resulted in the delayed progression of senile cataracts and subtle reduction in the opacification of the lens in humans and dogs [ 3 21 29 30 31 32 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of oral antioxidants on the progression of canine senile cataracts: a retrospective study

Park

Kang

Yoo³

et al. 2022

J Vet Sci

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Background Cataracts are the leading cause of impaired vision or blindness in dogs. There are many antioxidants that can prevent cataract progression, but whether they are clinically effective in dogs has not been established. Objectives To analyze the delaying or preventing effect of oral antioxidants on canine senile cataracts through retrospective analysis. Methods Medical records of dogs from January 1, 2015 to July 10, 2020 were reviewed. Dogs that were 8 yr of age or older with senile cataracts were included in this study. The dogs were divided into two treatment groups (dogs administered with Ocu-GLO supplement and dogs administered with Meni-One Eye R/C supplement) and a control group (dogs that were not administered any supplement). Dogs with incipient and immature cataracts were included in this study. Altogether, 112 dogs (156 eyes) with incipient cataracts and 60 dogs (77 eyes) with immature cataracts were included. The period of time that cataracts progressed from incipient to immature, and from immature to mature was recorded for each dog. Results There was no significant delaying effect on the progression of incipient cataracts. However, both Ocu-GLO (hazard ratio = 0.265, p = 0.026) and Meni-One (hazard ratio = 0.246, p = 0.005) significantly delayed the progression of immature cataracts compared to the control group. Conclusions Although there was no significant delaying effect of oral antioxidants on incipient cataract progression, antioxidants could be used to delay the progression of senile immature cataract.

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Section: Discussionmentioning

confidence: 99%

Effect of oral antioxidants on the progression of canine senile cataracts: a retrospective study

Park

Kang

Yoo³

et al. 2022

J Vet Sci

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Section: Effects Of Pirenoxine On Age-related Cataract: Evidence From...mentioning

confidence: 99%

“…In vivo studies revealed that PRX decelerated lens opacity and slowed the progression of age-related cataract [ 27 , 28 ]. Of these findings, one study showed that the effects of PRX were noticeable after 81.6 days of treatment [ 27 ]. Interestingly, these beneficial effects were more prominent in the cortical region of the lens, especially in younger models [ 27 ].…”

Section: Effects Of Pirenoxine On Age-related Cataract: Evidence From...mentioning

confidence: 99%

“…Of these findings, one study showed that the effects of PRX were noticeable after 81.6 days of treatment [ 27 ]. Interestingly, these beneficial effects were more prominent in the cortical region of the lens, especially in younger models [ 27 ]. However, results from clinical studies are controversial.…”

Section: Effects Of Pirenoxine On Age-related Cataract: Evidence From...mentioning

confidence: 99%

“…In contrast, Kary Uni can be instantly applied. Despite being available worldwide for over six decades, its efficacy is still controversial [ 12 , 15 , 16 , 17 , 18 , 24 , 25 , 26 , 27 , 28 , 29 ], and PRX has been mainly an off-label use for age-related cataract, its pathophysiology mainly being a result of increased oxidative stress in the lens [ 17 , 30 ]. Even though PRX is widely prescribed for age-related cataract, several researchers have shifted their focus to the benefits of PRX on diabetic cataract prevention and treatment [ 18 , 31 , 32 , 33 , 34 , 35 , 36 ].…”

Section: Introductionmentioning

confidence: 99%

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The Possible Positive Mechanisms of Pirenoxine in Cataract Formation

Upaphong

Thonusin

Choovuthayakorn

et al. 2022

IJMS

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Cataract is the leading cause of blindness worldwide. A diverse range of medication has been invented to prevent or treat cataract. Pirenoxine (PRX), a drug with strong antioxidant properties, has been used topically to treat cataract, and there is much evidence to demonstrate the beneficial effects of PRX on lens opacity from in vitro and in vivo models. In clinical use, PRX has been prescribed worldwide by ophthalmologists for over six decades; however, there is still controversy with regard to its efficacy, and thus PRX remains an off-label use for cataract treatment. This comprehensive review summarizes and discusses evidence pertinent to the mechanisms of PRX and its efficacy mainly on cataract models. The issues that have been deemed uncertain over the six-decade use of PRX are examined. The information summarized in this review should provide insights into contriving novel approaches for the treatment of cataract.

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Effect of Pirenoxine Ophthalmic Solution on Senile Incipient Cataract in Dogs

Cited by 2 publications

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Effect of oral antioxidants on the progression of canine senile cataracts: a retrospective study

Effect of oral antioxidants on the progression of canine senile cataracts: a retrospective study

The Possible Positive Mechanisms of Pirenoxine in Cataract Formation

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