Effect of pioglitazone treatment on brown adipose tissue volume and activity and hypothalamic gliosis in patients with type 2 diabetes mellitus: a proof-of-concept study

de-Lima-Júnior, José C.; Rodovalho, S.; Sande‐Lee, Simone van de; Monfort-Pires, Milena; Rachid, Briana; Cintra, Riobaldo M.R.; Ramos, Celso Darío; Cendes, Fernando; Folli, Franco; Velloso, Lı́cio A.

doi:10.1007/s00592-019-01418-2

Cited by 6 publications

(1 citation statement)

References 24 publications

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“…In vivo studies in humans identified the beta-receptor agonist mirabegron, melatonin, capsinoids, glucocorticoids, bile acid chenodeoxycholic acid and further dietary components like tea catechins and ephedrine affecting BAT activity 17 – 25 . Other substances under discussion include thiazolidinedione, resveratrol, thyroid hormones, the intestinal hormone secretin and cytarabine 26 – 30 . Additionally, active tumor disease itself might be associated with BAT activity 31 .…”

Section: Introductionmentioning

confidence: 99%

Determinants of activity of brown adipose tissue in lymphoma patients

Brendle

Stefan

Grams

et al. 2020

Sci Rep

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The determinants of brown adipose tissue (BAT) activity are not yet known in detail but might serve as future therapeutic targets against obesity and the metabolic syndrome. We analyzed 235 datasets of lymphoma patients with two PET/CT examinations at different time points retrospectively. We assessed the anthropometric characteristics, features related to the metabolic syndrome, thyroid dysfunction, season of the PET/CT examination, weight change, prior cancer history, lymphoma subgroups, disease activity, and specific lymphoma-related therapies, and evaluated their association with BAT activity. We found BAT activity in 12% of all examinations, and the incidence of BAT activity after initially negative examinations was 10%. In multivariate regression analysis, the prevalence of BAT activity was associated with age, body mass index, sex, the season of the examination, diabetes mellitus, arterial hypertension, and medication on the beta-receptors. New BAT activity arose more often in patients without preceding lymphoma-related therapy. No specific medication was associated with BAT activity. In conclusion, this study confirms the potential connection of BAT with the metabolic syndrome. Preceding lymphoma-related therapy might have an inhibitory effect on the recruitment of BAT.

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