Effect of piceatannol on circadian Per2 expression in vitro and in vivo

Yamamoto, Takayuki; Iwami, Shiho; Aoyama, Shogo; Maruki‐Uchida, Hiroko; Mori, Sadao; Hirooka, Rina; Takahashi, Kengo; Morita, Minoru; Shibata, Shigenobu

doi:10.1016/j.jff.2019.02.042

Cited by 12 publications

(11 citation statements)

References 56 publications

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“…Maternal supplementation with piceatannol is neuroprotective in rat neonatal hypoxia-ischemia [18]. Piceatannol affects peripheral clock gene expression and may prevent circadian disturbance [19].…”

Section: Introductionmentioning

confidence: 99%

Piceatannol Increases Antioxidant Defense and Reduces Cell Death in Human Periodontal Ligament Fibroblast under Oxidative Stress

et al. 2019

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Piceatannol is a resveratrol metabolite that is considered a potent antioxidant and cytoprotector because of its high capacity to chelate/sequester reactive oxygen species. In pathogenesis of periodontal diseases, the imbalance of reactive oxygen species is closely related to the disorder in the cells and may cause changes in cellular metabolism and mitochondrial activity, which is implicated in oxidative stress status or even in cell death. In this way, this study aimed to evaluate piceatannol as cytoprotector in culture of human periodontal ligament fibroblasts through in vitro analyses of cell viability and oxidative stress parameters after oxidative stress induced as an injury simulator. Fibroblasts were seeded and divided into the following study groups: control, vehicle, control piceatannol, H2O2 exposure, and H2O2 exposure combined with the maintenance in piceatannol ranging from 0.1 to 20 μM. The parameters analyzed following exposure were cell viability by trypan blue exclusion test, general metabolism status by the 3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyltetrazolium bromide (MTT) method, mitochondrial activity through the ATP production, total antioxidant capacity, and reduced gluthatione. Piceatannol was shown to be cytoprotective due the maintenance of cell viability between 1 and 10 μM even in the presence of H2O2. In a concentration of 0.1 μM piceatannol decreased significantly cell viability but increased cellular metabolism and antioxidant capacity of the fibroblasts. On the other hand, the fibroblasts treated with piceatannol at 1 μM presented low metabolism and antioxidant capacity. However, piceatannol did not protect cells from mitochondrial damage as measured by ATP production. In summary, piceatannol is a potent antioxidant in low concentrations with cytoprotective capacity, but it does not prevent all damage caused by hydrogen peroxide.

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Section: Introductionmentioning

confidence: 99%

Piceatannol Increases Antioxidant Defense and Reduces Cell Death in Human Periodontal Ligament Fibroblast under Oxidative Stress

et al. 2019

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“…In 2019, Yanamoto et al studied the effect of PIC on circadian Per2 (peripheral clock gene) expression using bioluminescence in mPer2Luc cells knock-in mice and their embryonic fibroblasts. 68 In vitro, results showed that PIC accelerates and slows down the PER2::LUC oscillation phase due to the difference in treatment time. In vivo imaging system, oral administration of PIC significantly increases peripheral rhythmic PER2::LUC luminescence.…”

Section: Piceatannol Human Mesenchymal Stem Cells (Hmsc)mentioning

confidence: 98%

“…Protective effects of PIC against cardiovascular diseases are shown in Figure 5. In 2019, Yanamoto et al studied the effect of PIC on circadian Per2 (peripheral clock gene) expression using bioluminescence in mPer2Luc cells knock‐in mice and their embryonic fibroblasts 68 . In vitro, results showed that PIC accelerates and slows down the PER2::LUC oscillation phase due to the difference in treatment time.…”

Section: Activity Of Piceatannol On Various Diseasesmentioning

confidence: 99%

Exploring the therapeutic potential of naturally occurring piceatannol in non‐communicable diseases

Gandhi,

Mahant,

Sharma

et al. 2023

BioFactors

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Piceatannol is a naturally occurring hydroxylated resveratrol analogue that can be found in a variety of fruits and vegetables. It has been documented to have a wide range of beneficial effects, including anti‐inflammatory, antioxidant, anti‐aging, anti‐allergic, antidiabetic, neuroprotective, cardioprotective, and chemopreventive properties. Piceatannol has significantly higher antioxidant activity than resveratrol. Piceatannol has been shown in preclinical studies to have the ability to inhibit or reduce the growth of cancers in various organs such as the brain, breast, lung, colon, cervical, liver, prostate, and skin. However, the bioavailability of Piceatannol is comparatively lower than resveratrol and other stilbenes. Several approaches have been reported in recent years to enhance its bioavailability and biological activity, and clinical trials are required to validate these findings. This review focuses on several aspects of natural stilbene Piceatannol, its chemistry, and its mechanism of action, and its promising therapeutic potential for the prevention and treatment of a wide variety of complex human diseases.

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“…160 Likewise, in PER::LUC mice with a high fat diet, a significant delay in the phase change of PER2 had been observed and the administration of oxyresveratrol successfully advanced the rhythm, thus potentially preventing circadian disturbance. 161 Hence, since circadian rhythms are closely interrelated with overall metabolism, the effects of stilbenes against circadian dysregulation highlight their potential as precautionary therapeutics, especially under various disruptions stemming from changes in modern lifestyle.…”

Section: Hypoglycemic Effect Of Resveratrol and Related Stilbenes And...mentioning

confidence: 99%

Hypoglycemic effects and associated mechanisms of resveratrol and related stilbenes in diet

Peng,

Lu,

Luo

et al. 2024

Food Funct.

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Effect of piceatannol on circadian Per2 expression in vitro and in vivo

Cited by 12 publications

References 56 publications

Piceatannol Increases Antioxidant Defense and Reduces Cell Death in Human Periodontal Ligament Fibroblast under Oxidative Stress

Piceatannol Increases Antioxidant Defense and Reduces Cell Death in Human Periodontal Ligament Fibroblast under Oxidative Stress

Exploring the therapeutic potential of naturally occurring piceatannol in non‐communicable diseases

Hypoglycemic effects and associated mechanisms of resveratrol and related stilbenes in diet

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