Effect of Physical Exercise on Colorectal Cancer: Systematic Review

Abstract

Aerobic and resistance physical exercise can activate different molecular pathways due to different intensities, duration, and mechanical loads imposed on the muscles. The activity can result in metabolic adaptations, such as increased mitochondrial mass, oxygen supply, glucose uptake, and antioxidant capacity. The method of this systematic review followed recommendations proposed by the PRISMA Statement. Were included studies that used physical exercise as an intervention in rats and mice with induced colorectal cancer. The Studies' selection was on databases: Bireme, PubMed, Science Direct, Medline, Ibecs, Lilacs, Bdenf, Binacis, Scielo, and bibliographic references selected articles. Animal models researches showed that aerobic and resistance exercise could reduce several risk factors like oxidating stress and the tumor's pro-inflammatory status. That happens due to cytokines' regulation, thereby improve organic's defenses and reduce colon inflammation.