Effect of Phototherapy on Zinc Status in Term Neonates With Indirect Hyperbilirubinemia

El-Magid, Mahmoud Ali Ahmed Abd; El-Samannody, Mohamed Ibrahim; El-Mazahy, Mohamed Mohamed; El-Ghannam, Magdy Zaki

doi:10.21608/amj.2021.139848

Cited by 2 publications

(3 citation statements)

References 7 publications

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“…These properties could be valuable in heme catabolism and bilirubin production [108,109]. Its combination with phototherapy may be beneficial and safe for reducing the level of bilirubin and the duration of phototherapy in term and premature newborns with indirect jaundice [110][111][112][113]. A group of researchers tested and found that phototherapy has no effect on the level of zinc in the serum.…”

Section: Zinc Sulfatementioning

confidence: 99%

“…A group of researchers tested and found that phototherapy has no effect on the level of zinc in the serum. However, zinc supplements are encouraged in cases of neonatal jaundice, because they are usually zinc deficient [111]. On the other hand, another group of researchers claimed that it must be taken into account that there could be a risk of raising the level of zinc in the serum during phototherapy.…”

Section: Zinc Sulfatementioning

confidence: 99%

“…On the other hand, another group of researchers claimed that it must be taken into account that there could be a risk of raising the level of zinc in the serum during phototherapy. Therefore, giving zinc supplements, together with intensive phototherapy, may cause zinc toxicity, and is thus not appropriate for newborns with high levels of indirect bilirubin in the serum under intensive phototherapy treatment [111]. There is no consensus regarding a recommendation for zinc supplementation in these newborns.…”

Section: Zinc Sulfatementioning

confidence: 99%

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“Light” on Phototherapy—Complications and Strategies for Shortening Its Duration, A Review of the Literature

Shoris,

Gover,

Toropine

et al. 2023

Children

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Neonatal hyperbilirubinemia is an extremely common metabolic complication of the neonatal period which may be associated with bilirubin encephalopathy and even death. Adverse neurological consequences are preventable if a timely diagnosis and treatment are provided. Phototherapy is usually the preferred option to decrease hyperbilirubinemia. Although considered to be safe, evidence in recent years has shown that this treatment may not be free of side effects and short- and long-term unfavorable outcomes. These are usually mild or rare, but should be decreased or avoided if possible. Many useful complementary measures and treatments have been described that could shorten the duration of exposure to phototherapy. However, there is no current unequivocal recommendation to use any of the methods presented in this review. Our review aims to depict the wide range of possible complementary treatments to phototherapy, and to provide the scientific and clinical evidence available regarding their usefulness. It is essential that, while utilizing the full potential of phototherapy to treat hyperbilirubinemia, caregivers are aware of its side effects and possible inherent dangers, and seek ways to minimize the exposure to phototherapy to what is really needed for the newborn. Further studies are needed to clarify the preferred complementary treatments that could reduce the duration of exposure to phototherapy without impairing its effectiveness.

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Section: Zinc Sulfatementioning

confidence: 99%

Section: Zinc Sulfatementioning

confidence: 99%

Section: Zinc Sulfatementioning

confidence: 99%

See 1 more Smart Citation

“Light” on Phototherapy—Complications and Strategies for Shortening Its Duration, A Review of the Literature

Shoris,

Gover,

Toropine

et al. 2023

Children

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Recent Advances in Adjuvant Pharmacotherapy for Neonatal Indirect Hyperbilirubinemia: A Narrative Review

Nouri

Zarkesh

2023

J Compr Ped

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Context: Hyperbilirubinemia is a common cause for diagnostic work-up and therapeutic intervention in neonates and needs a convenient, quick, and safe treatment modality. Phototherapy is the most common treatment for neonatal jaundice; however, complementary treatment is still needed. Despite the identification of the enzymatic pathways of bilirubin catabolism, few pharmacological interventions have been found to be effective in reducing bilirubin, along with traditional phototherapy. This review was conducted to evaluate recent pharmacotherapies as adjuvants to phototherapy for the treatment of neonatal indirect hyperbilirubinemia (IHB). Evidence Acquisition: This study was carried out through a literature search with the keywords of Infant, Newborn, and Indirect Hyperbilirubinemia, combined with Drug Therapy, in PubMed, Scopus, International Statistical Institute, Web of Science, Cochrane, and Embase databases. This study included relevant articles (i.e., randomized controlled trials, observational studies, guidelines, and reviews) written in English and published between 2012 - 2022. Results: This narrative review first assessed the relevant articles to define IHB and its etiology. Then, the efficacy and side effects of recent pharmacologic agents as adjuvants to phototherapy were discussed. Additionally, this study reviewed the efficacy and safety of drugs prescribed to neonates to prevent jaundice. Conclusions: The best drug for adjuvant pharmacotherapy, in addition to phototherapy, for neonatal jaundice has not still been identified. The use of probiotics, prebiotics, synbiotics, and ursodeoxycholic acid (UDCA) in adjuvant to phototherapy has been recently increasing, and beneficial results were observed in most studies. The use of agar, charcoal, fibrate, and phenobarbital had a minor therapeutic role in recent years. There were conflicting results about the efficacy of herbal agents in neonatal jaundice. The use of intravenous immunoglobulin (IVIG), metalloporphyrin, and albumin is also limited to severe or immune-related IHB cases. The prescription of the aforementioned drugs sometimes had different results. Therefore, further research in this regard is necessary.

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Effect of Phototherapy on Zinc Status in Term Neonates With Indirect Hyperbilirubinemia

Cited by 2 publications

References 7 publications

“Light” on Phototherapy—Complications and Strategies for Shortening Its Duration, A Review of the Literature

“Light” on Phototherapy—Complications and Strategies for Shortening Its Duration, A Review of the Literature

Recent Advances in Adjuvant Pharmacotherapy for Neonatal Indirect Hyperbilirubinemia: A Narrative Review

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