Effect of Photofunctionalization on Early Implant Failure

Hirota, Makoto; Ozawa, Tomomichi; Iwai, Toshinori; Ogawa, Takahiro; Tohnai, Iwai

doi:10.11607/jomi.6541

Cited by 29 publications

(33 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…UV-photofunctionalization is more effective on micro-roughened Ti surfaces [5], promoting osteoblast differentiation and rapid osseointegration [9][10][11]. Photofunctionalized dental implants improved a risk of early failure [12] and promised faster and stable osseointegration even in extremely poor conditions [13].…”

Section: Introductionmentioning

confidence: 99%

Tuning of Titanium Microfiber Scaffold with UV-Photofunctionalization for Enhanced Osteoblast Affinity and Function

Iwasaki

Hirota

Tanaka

et al. 2020

IJMS

Self Cite

View full text Add to dashboard Cite

Titanium (Ti) is an osteoconductive material that is routinely used as a bulk implant to fix and restore bones and teeth. This study explored the effective use of Ti as a bone engineering scaffold. Challenges to overcome were: (1) difficult liquid/cell infiltration into Ti microfiber scaffolds due to the hydrophobic nature of Ti; and (2) difficult cell attachment on thin and curved Ti microfibers. A recent discovery of UV-photofunctionalization of Ti prompted us to examine its effect on Ti microfiber scaffolds. Scaffolds in disk form were made by weaving grade 4 pure Ti microfibers (125 µm diameter) and half of them were acid-etched to roughen the surface. Some of the scaffolds with original or acid-etched surfaces were further treated by UV light before cell culture. Ti microfiber scaffolds, regardless of the surface type, were hydrophobic and did not allow glycerol/water liquid to infiltrate, whereas, after UV treatment, the scaffolds became hydrophilic and immediately absorbed the liquid. Osteogenic cells from two different origins, derived from the femoral and mandibular bone marrow of rats, were cultured on the scaffolds. The number of cells attached to scaffolds during the early stage of culture within 24 h was 3–10 times greater when the scaffolds were treated with UV. The development of cytoplasmic projections and cytoskeletal, as well as the expression of focal adhesion protein, were exclusively observed on UV-treated scaffolds. Osteoblastic functional phenotypes, such as alkaline phosphatase activity and calcium mineralization, were 2–15 times greater on UV-treated scaffolds, with more pronounced enhancement on acid-etched scaffolds compared to that on the original scaffolds. These effects of UV treatment were associated with a significant reduction in atomic carbon on the Ti microfiber surfaces. In conclusion, UV treatment of Ti microfiber scaffolds tunes their physicochemical properties and effectively enhances the attachment and function of osteoblasts, proposing a new strategy for bone engineering.

show abstract

Section: Introductionmentioning

confidence: 99%

Tuning of Titanium Microfiber Scaffold with UV-Photofunctionalization for Enhanced Osteoblast Affinity and Function

Iwasaki

Hirota

Tanaka

et al. 2020

IJMS

Self Cite

View full text Add to dashboard Cite

show abstract

“…Similarly, Suzuki et al (2013), using an immediate loading protocol, showed considerably higher values of implant stability quotients for photofunctionalized implants. In addition, retrospective studies also demonstrated a positive outcome on implant healing time and stability as well as a decrease in early implant failure Hirota et al, 2018). Despite the fact that some of the abovementioned studies were included after the screening of titles and abstracts in the full-text reading, they were excluded from this systematic review and meta-analysis because they were case series or did not present control groups for the evaluated outcomes, but underlined the effects determined in vitro and in vivo.…”

Section: F I G U R Ementioning

confidence: 90%

“…Nevertheless, dental implant photofunctionalization has already been evaluated in clinical studies with increased marginal bone levels and implant stability quotients Hirota et al, 2018;Suzuki et al, 2013). A case series study showed the positive effect of photofunctionalization for implant stability quotient and marginal bone levels in clinically challenging scenarios with compromised bone conditions .…”

Section: F I G U R Ementioning

confidence: 99%

“…The potential advantages of photofunctionalization have also been demonstrated in animal models (Ishijima et al, 2016;Kim et al, 2016;Mehl et al, 2018;Park, Koak, Kim, Han, & Heo, 2013;Sawase et al, 2007) and clinical studies Funato, Yamada, & Ogawa, 2013;Hirota, Ozawa, Iwai, Ogawa, & Tohnai, 2018;Suzuki, Kobayashi, & Ogawa, 2013). It is wellknown from previous studies that peri-implant bone healing and the quantitative data for bone integration on the implant surface can be reliably assessed by histological evaluation of the boneto-implant contact (BIC) in animal models (Fraser et al, 2019;Han et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Photofunctionalization as a suitable approach to improve the osseointegration of implants in animal models—A systematic review and meta‐analysis

Dini

Nagay

Magno

et al. 2020

Clinical Oral Implants Res

View full text Add to dashboard Cite

Objectives To determine whether photofunctionalization influences dental implant osseointegration. Material and methods Data on osseointegration rates were extracted from 8 databases, based on bone‐to‐implant contact (BIC) and pushout tests. Internal validity was accessed through the SYRCLE risk of bias tool for animal experimental studies. Meta‐analyses were performed for investigation of the influence of photofunctionalization on implant osseointegration, with a random effect and a confidence interval of 95%. The certainty of evidence was accessed through the GRADE approach. Results Thirty‐four records were identified, and 10 were included in the meta‐analysis. Photofunctionalized implants showed higher mean values for BIC in rabbits (MD 6.92 [1.01, 12.82], p = .02), dogs (MD 23.70 [10.23, 37.16], p = .001), rats (MD 20.93 [12.91, 28.95], p < .0001), and in the pooled BIC analyses (MD 14.23 [7.80, 20.66], p < .0001) compared to those in control implants in the overall assay. Conversely, at late healing periods, the pooled BIC meta‐analyses showed no statistically significant differences (p > .05) for photofunctionalized and control implants at 12 weeks of follow‐up. For pushout analysis, photofunctionalized implants presented greater bone strength integration (MD 19.92 [13.88, 25.96], p < .0001) compared to that of control implants. The heterogeneity between studies ranged from “not important” to “moderate” for rabbits I2 = 24%, dogs I2 = 0%, rats I2 = 0%, and pooled BIC (I2 = 49%), while considerable heterogeneity was observed for pushouts (I2 = 90%). Conclusion Photofunctionalization improves osseointegration in the initial healing period of implants, as summarized from available data from rabbit, dog, and rat in vivo models.

show abstract

“…A previous clinical study showed that the stability of implants inserted into the patients' jaw bones increased more rapidly when the implants were UV-photofunctionalized [121]. The retrospective clinical studies concluded that UV-mediated photofunctionalization reduced early implant failure, and the success rate of the photofunctionalized implants was 97.6% during the functional loading period of approximately 2.5 years [122,123]. No prospective long-term clinical study (published in English) evaluating UV-mediated photofunctionalization has yet been found in the field of implant dentistry.…”

Section: Photofunctionalizationmentioning

confidence: 99%

Modifications of Dental Implant Surfaces at the Micro- and Nano-Level for Enhanced Osseointegration

2019

View full text Add to dashboard Cite

This review paper describes several recent modification methods for biocompatible titanium dental implant surfaces. The micro-roughened surfaces reviewed in the literature are sandblasted, large-grit, acid-etched, and anodically oxidized. These globally-used surfaces have been clinically investigated, showing survival rates higher than 95%. In the past, dental clinicians believed that eukaryotic cells for osteogenesis did not recognize the changes of the nanostructures of dental implant surfaces. However, research findings have recently shown that osteogenic cells respond to chemical and morphological changes at a nanoscale on the surfaces, including titanium dioxide nanotube arrangements, functional peptide coatings, fluoride treatments, calcium–phosphorus applications, and ultraviolet photofunctionalization. Some of the nano-level modifications have not yet been clinically evaluated. However, these modified dental implant surfaces at the nanoscale have shown excellent in vitro and in vivo results, and thus promising potential future clinical use.

show abstract

Effect of Photofunctionalization on Early Implant Failure

Cited by 29 publications

References 0 publications

Tuning of Titanium Microfiber Scaffold with UV-Photofunctionalization for Enhanced Osteoblast Affinity and Function

Tuning of Titanium Microfiber Scaffold with UV-Photofunctionalization for Enhanced Osteoblast Affinity and Function

Photofunctionalization as a suitable approach to improve the osseointegration of implants in animal models—A systematic review and meta‐analysis

Modifications of Dental Implant Surfaces at the Micro- and Nano-Level for Enhanced Osseointegration

Contact Info

Product

Resources

About