Effect of Phonophoresis on Skin Permeation of Commercial Anti-inflammatory Gels: Sodium Diclofenac and Ketoprofen

Souza, Josiane de; Meira, Alianise da Silva; Volpato, Nádia Maria; Mayorga, Paulo; Gottfried, Carmem

doi:10.1016/j.ultrasmedbio.2013.02.009

Cited by 18 publications

(11 citation statements)

References 53 publications

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“…Лікування гострого больового синдрому передбачає призначення нестероїдних протизапальних препаратів (НПЗП), глюкокортикоїдів (ГКС), хворобомодифікуючих агентів та нефармакологічних методів лікування (модифікація способу життя, фізіотерапевтичні процедури, акупунктура, лікувальна фізкультура, використання допоміжного обладнання та ортезів) [1,26].…”

Section: вступunclassified

Efficiency of the combination of physical therapy modalities with topical nonsteroidal anti-inflammatory drugs for treatment of pain in rheumatology

Kapeltsova

Dolynna

Shkolina

et al. 2018

PMJUA

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Pain is the most common syndrome in rheumatology. NSAIDs are often used in its treatment. But they have limitations associated with side effects. An advantage of topical drugs and physical factors (electrophoresis, phonophoresis) combination is the use of low doses of the drug and a decrease in time, to achieve a therapeutic effect, reduce the risk of adverse reactions, increase the concentration of the drug in the inflammation focus, prolonged action (creating a drug depot in tissues). Ketoprofen gel (“Artrocol gel”) is one of the representatives of this pharmacological group. Physicochemical properties help ketoprofen to penetrate easily through the skin and create a therapeutic concentration in the underlying tissues. Objective. To assess the effectiveness of ketoprofen gel (“Arthrocol gel”) electrophonophoresis in the treatment of pain in rheumatological patients. Materials and methods. The study was carried out on the basis of Physiotherapy Department of Vinnytsia Regional Clinical Hospital named after M. I. Pirogov. All patients treated according to the unified clinical protocols were divided into experimental group (EG) and control group (CG). Patients of EG (98 persons) underwent electrophonophoresis with ketoprofen gel once a day for a week. In CG (43 persons) ketoprofen gel was used without electrophonophoresis. The intensity of the pain syndrome is monitored using a visual analog scale (VAS) of Huskisson at rest and during movement. A week later, the patient and the doctor evaluated satisfaction with the results of treatment on the scale: not effective, insufficient, satisfactory, good, excellent. Results. There was a persistent decrease in the intensity of pain syndrome in patients of both groups. The VAS scores were lower in the EG starting from the 3rd day of treatment. The intensity of the acute pain syndrome after 1-week treatment at rest (t = 4.71, p < 0.001) and during the movement (t = 3.84, p < 0.001) more decrease in EG. Satisfaction with the results of treatment was higher in EG.

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Section: вступunclassified

Efficiency of the combination of physical therapy modalities with topical nonsteroidal anti-inflammatory drugs for treatment of pain in rheumatology

Kapeltsova

Dolynna

Shkolina

et al. 2018

PMJUA

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“…Ультрафонофорез используется прежде всего с целью репарации и регенерации [14,31]. В литературе описан эффект фонофореза с препаратами, содержащими диметилсульфоксид и хондроитина сульфат [32], кетопрофен [33][34][35], пироксикам [36,37] и ряд других компонентов [34]. В последних «Рекомендациях консенсуса по борьбе с болью при ОА локальными формами НПВП в Азиатско-Тихоокеанском регионе» (Consensus recommendations for managing osteoarthritic pain with topical NSAIDs in Asia-Pacific) прямо указывается на возможность применения метода фонофореза для доставки соответствующих лекарственных веществ [38].…”

Section: х а р а к т е р и с т и к а п а ц и е н т о в 1 -й и 2 -й г unclassified

Ultraphonophoresis with a hyaluronic acid-containing gel for knee osteoarthritis with periarthritis

Аношенкова¹,

Калягин

Максимова³

et al. 2018

Sovremennaâ revmatologiâ

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Ведение больных остеоартритом (ОА) коленных суставов на фоне коморбидной патологии вызывает существенные трудности, связанные с ограничениями фармакотерапии. Цель исследования-оценка клинической эффективности ультрафонофореза с гелем, содержащим гиалуроновую кислоту (ГнК), у пациентов с ОА коленных суставов, осложненным периартритом. Пациенты и методы. В открытом наблюдательном сравнительном исследовании участвовали 30 пациентов с достоверным диагнозом ОА коленных суставов, которые были разделены на две группы: в 1-й (основной) группе (n=15) в течение 10 дней проводили ультрафонофорез с гелем, содержащим ГнК; во 2-й (контрольной, n=15)-ультрафонофорез с интактным гелем. Для определения клинической эффективности утрафонофореза с гелем, содержащим ГнК, проводили опрос пациентов, клинический осмотр с пальпацией коленных суставов для выявления синовита и периартрита, УЗИ, а также оценку стартовой боли и боли при ходьбе по 100-миллиметровой визуальной аналоговой шкале (ВАШ) боли.

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“…The importance of factoring in drug properties when selecting an adjunct to phonophoresis was shown in a study that evaluated skin permeation of diclofenac gel and ketoprofen gel in the Franz diffusion cell model adapted to an ultrasound transducer under conditions of no ultrasound, one application of ultrasound and two applications of ultrasound [49]. Permeation of ketoprofen increased with two ultrasound applications, whereas that of diclofenac decreased in the presence of ultrasound.…”

Section: Does Phonophoresis Affect Skin Permeation Of Topical Nsaids?mentioning

confidence: 99%

Consensus Recommendations for Managing Osteoarthritic Pain with Topical NSAIDs in Asia-Pacific

Rafanan¹,

Valdecanas²,

Lim

et al. 2017

Pain Manag.

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Osteoarthritis prevalence is expected to increase markedly in the Asia-Pacific region due to rapid population aging. Identifying effective and safe therapeutic options to manage osteoarthritic pain is viewed as a priority. The Asia-Pacific Experts on Topical Analgesics Advisory Board developed consensus statements for use of topical NSAIDs in musculoskeletal pain. Evidence supporting these statements in osteoarthritic pain was reviewed. Best available evidence indicates that topical NSAIDs have a moderate effect on relief of osteoarthritic pain, comparable to that of oral NSAIDs but with a better risk-to-benefit ratio. International clinical practice guidelines recommend topical NSAIDs on par with or ahead of oral NSAIDs for pain management in patients with knee and hand osteoarthritis, and as the first-line choice in persons aged ≥75 years.

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Effect of Phonophoresis on Skin Permeation of Commercial Anti-inflammatory Gels: Sodium Diclofenac and Ketoprofen

Cited by 18 publications

References 53 publications

Efficiency of the combination of physical therapy modalities with topical nonsteroidal anti-inflammatory drugs for treatment of pain in rheumatology

Efficiency of the combination of physical therapy modalities with topical nonsteroidal anti-inflammatory drugs for treatment of pain in rheumatology

Ultraphonophoresis with a hyaluronic acid-containing gel for knee osteoarthritis with periarthritis

Consensus Recommendations for Managing Osteoarthritic Pain with Topical NSAIDs in Asia-Pacific

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