Effect of Phenytoin on Antibody Production: Use of a Murine Model

Margaretten, Nadine C.; Warren, Reed P.

doi:10.1111/j.1528-1157.1987.tb03627.x

Cited by 13 publications

(2 citation statements)

References 15 publications

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“…Although there are variable studies concerning the effect of phenytoin on immunoglobulin production in vivo [6,9,30,31], phenytoin administration did not reduce the serum levels of total IgG and IgE in this study (data not shown). This may be due to the species and strains of animals used for experiments, administered dose of phenytoin, and the antigen used for immunization.…”

Section: Discussioncontrasting

confidence: 55%

Phenytoin promotes Th2 type immune response in mice

Okada

Sugiura²,

Kuroda³

et al. 2001

Clinical and Experimental Immunology

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The effects of chronic administration of phenytoin, a common anticonvulsive drug, on immune responses were studied in mice. Anti‐keyhole limpet haemocyanin (KLH) IgE antibody response after KLH‐immunization was enhanced in phenytoin‐treated mice. Proliferative responses of spleen cells induced with KLH, concanavalin A (ConA), lipopolysaccharide and anti‐CD3 antibody were reduced in phenytoin‐treated mice. Accessory function of spleen adherent cells on ConA‐induced T cell proliferative response was reduced in phenytoin‐treated mice. KLH‐induced IL‐4 production of spleen cells was enhanced, while IFN‐γ production was reduced in phenytoin‐treated mice. In addition, production of IL‐1α, but not IL‐6 and IL‐12 by spleen adherent cells from phenytoin‐treated mice was reduced. Natural killer cell activity was reduced in phenytoin‐treated mice. These results suggest that phenytoin treatment preferentially induces a Th2 type response. We also observed that plasma ACTH and corticosterone levels were increased in phenytoin‐treated mice, and speculated that phenytoin might act directly and indirectly, through HPA axis activation, on the immune system to modulate Th1/Th2 balance.

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Section: Discussioncontrasting

confidence: 55%

Phenytoin promotes Th2 type immune response in mice

Okada

Sugiura²,

Kuroda³

et al. 2001

Clinical and Experimental Immunology

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“…1982; Bardana et al, 1983;Mauguiere and Courson 1983;Chapman et Roberts, 1984;Sorrell and Forbes, 1975;Margaretten and Warren, 1987). PHT-induced abnormalities have been suggested to result from an alteration in suppressor T-cell function (Fontana, 1983).…”

Section: E Andrade-mena Et Almentioning

confidence: 99%

Effects of Carbamazepine on Murine Humoral and Cellular Immune Responses

Andrade-Mena¹,

Sardo‐Olmedo²,

Ramírez-Lizardo³

1994

Epilepsia

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Oral administration of carbamazepine (CBZ) (15, 10, or 5 mg/kg) to mice significantly decreased both humoral and cellular immune responses evaluated by enumeration of direct and indirect plaque-forming spleen cells (PFC) and delayed-type hypersensitivity reaction (DTH) against sheep red blood cells (SRBC) as compared with those observed in normal control animals. Moreover, spleen T cells obtained from CBZ-treated donor mice were capable of decreasing both PFC and DTH responses of normal spleen cells transferred into lethally irradiated recipient animals. The immunodepressor effect of CBZ was observed even though administration of CBZ induced augmentation of spleen cellularity.

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