Effect of pH-Sensitive P(MAA-co-PEGMA) Hydrogels on Release and Stability of Albumin

Abstract

pH-sensitive P(MAA-co-PEGMA) hydrogel particles were prepared and their feasibility as smart delivery carriers for cosmetic ingredients was evaluated. P(MAA-co-PEGMA) hydrogel particles having an average size of approx. 2 µm were synthesized via dispersion photopolymerization. There was a drastic change in the swelling ratio of P(MAAco-PEGMA) particles at a pH of around 5 due to the ionization of MAA in the hydrogel and as the amount of MAA in the hydrogel increased, the swelling ratio increased at a pH above 5. The P(MAA-co-PEGMA) hydrogel particles showed a pH-sensitive release behavior. Thus, at pH 4 almost none of the albumin permeated through the skin while at pH 6 relatively high skin permeability was obtained. The albumin loaded in the P(MAA-co-PEGMA) hydrogel particles was hardly degraded in the presence of pepsin and its stability was maintained.Keywords: pH-sensitive, hydrogel particles, albumin stability, smart delivery system, skin permeability.

Preparation and characterization of thermoresponsive poly(N‐isopropylacrylamide‐co‐N‐isopropylmethacrylamide) hydrogel materials for smart windows

“…6 Stimulus sensitive polymers have reversible and repetitive changes in chemical and physical properties in response to external stimuli, such as, light, 7,8 temperature, 2,9 and pH. 10,11 In particular, thermoresponsive (temperature-responsive) polymers using temperature as a stimulus source exhibit reversible sol-gel phase transition or volume phase transition at a specific temperature. This temperature is called lower critical solution temperature (LCST).…”