“…MLV exhibit, under heating, a characteristic transition from the gel (L b ) phase to the liquid crystal (L a ) phase [13][14][15][16] that can be revealed by DSC by measuring the associated thermodynamic parameters (transition temperature, T m , and enthalpy changes, DH). Amphiphilic compounds, interacting with the phospholipid bilayers, may cause modification of the lipid chain packing, resulting in a variation of the transition thermodynamic parameters [11,[16][17][18][19][20][21][22][23][24]. This behavior, which can be analyzed by the Van't Hoff model of the freezing point depression of solutions, has been verified for several classes of chemical compounds, such as anesthetics [24], and applied on theoretical basis by some researchers [24][25][26]; the deviations from the model due to the complex structure as well as to the size of the compounds have been also taken into account [15,27].…”