Effect of peroxisomicine A2and T 544 of the genusKarwinskiaon peroxisomes ofCandida boidinii

Salazar‐Aranda, Ricardo; Sepúlveda-Saavedra, Julio; Torres, Noemıć Waksman de; Piñeyro-López, Alfredo; Moreno-Sepúlveda, Myrthala

doi:10.1111/j.1574-6968.1998.tb12829.x

Cited by 8 publications

(4 citation statements)

References 10 publications

(10 reference statements)

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“…As mentioned earlier, this was the reason by which T514 was renamed peroxisomicine A1 (PA1). PA2 and T544 produce a similar effect on C. boidinii [86].…”

Section: Karwinskia As a Potential Antineoplastic Agentmentioning

confidence: 77%

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Toxicity and Anticancer Potential of Karwinskia: A Review

et al. 2020

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Karwinskia genus consists of shrubs and small trees. Four toxic compounds have been isolated from Karwinskia plants, which were typified as dimeric anthracenones and named T496, T514, T516, and T544. Moreover, several related compounds have been isolated and characterized. Here we review the toxicity of the fruit of Karwinskia plants when ingested (accidentally or experimentally), as well as the toxicity of its isolated compounds. Additionally, we analyze the probable antineoplastic effect of T514. Toxins cause damage mainly to nervous system, liver, lung, and kidney. The pathophysiological mechanism has not been fully understood but includes metabolic and structural alterations that can lead cells to apoptosis or necrosis. T514 has shown selective toxicity in vitro against human cancer cells. T514 causes selective and irreversible damage to peroxisomes; for this reason, it was renamed peroxisomicine A1 (PA1). Since a significant number of malignant cell types contain fewer peroxisomes than normal cells, tumor cells would be more easily destroyed by PA1 than healthy cells. Inhibition of topoisomerase II has also been suggested to play a role in the effect of PA1 on malignant cells. More research is needed, but the evidence obtained so far indicates that PA1 could be an effective anticancer agent.

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“…As mentioned earlier, this was the reason by which T514 was renamed peroxisomicine A1 (PA1). PA2 and T544 produce a similar effect on C. boidinii [86].…”

Section: Karwinskia As a Potential Antineoplastic Agentmentioning

confidence: 77%

“…In the experiments with yeasts described above in which peroxisomes were damaged by PA1, PA2, and T544 [16,86], inhibition of CAT was also not observed.…”

Section: Karwinskia As a Potential Antineoplastic Agentmentioning

confidence: 79%

Toxicity and Anticancer Potential of Karwinskia: A Review

et al. 2020

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“…These metabolites have been extensively studied in Karwinskia, a genus closely related to Rhamnidium (Hauenschild et al, 2016;Richardson et al, 2004). Some hydroxyanthracenones have been shown to exhibit antimicrobial and antifungal activities (Salazar-Aranda et al, 1998;Salazar et al, 2006) and toxic properties (Bermudez et al, 1986;Martínez et al, 1997;Piñeyro-Lopez and Waksman, 2000;Rojas-Flores et al, 2014). This nding serves as a warning to the Pantanal population who have been using R. elaeocarpum barks for food and therapeutic purposes (Bieski et al, 2012;Bortolotto et al, 2018;Pott and Pott, 1994).…”

Section: Discussionmentioning

confidence: 99%

Unraveling the Adaptive Chemical Traits of Rhamnidium elaeocarpum in Response to Fire and Environmental Factors in Pantanal Wetlands

Siqueira

Santos

Júnior

et al. 2023

Preprint

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We conducted a study on the effects of fire on Rhamnidium elaeocarpum, a widely distributed woody species found in the Pantanal wetlands, using LC-MS metabolomics, total phenolic and tannin content analysis, and thermogravimetric behavior. We sampled individuals from four different groups and found that recent fires had no significant impact on the species' phenolic metabolism, except for those specimens whose aerial parts had died during the 2020 megafire, which showed a compound decline due to leaching. The high levels of phenolics in R. elaeocarpum suggest that the species has a biochemical tolerance to the stress caused by seasonal fires. Metabolomic profiling revealed the presence of proanthocyanidin oligomers, which protect against oxidative stress and post-fire environmental disturbances. However, the passage of fire also led to a high incidence of toxic karwinaphthopyranone derivatives, which could be a concern for the species' medicinal use. Finally, the thermogravimetric analysis showed that the species is thermotolerant, with an intrinsic relationship between the secondary compounds and thermotolerance. Our study enhances our understanding of the impact of fire on woody species' metabolism, although distinguishing whether chemical traits are an adaptive feature or a response to surrounding environmental factors is challenging.

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“…These metabolites have been extensively studied in Karwinskia , a genus closely related to Rhamnidium 82 , 83 . Some hydroxyanthracenones, have been shown to exhibit antimicrobial and antifungal activities 84 , 85 and toxic properties 52 , 58 , 86 , 87 . This finding serves as a warning to the Pantanal population who have been using R. elaeocarpum barks for food and therapeutic purposes 29 , 30 , 88 , since the effects of long-term effects on the organism are still unknown.…”

Section: Discussionmentioning

confidence: 99%

Unraveling the adaptive chemical traits of Rhamnidium elaeocarpum Reissek in response to fire in pantanal wetlands

Siqueira¹,

Santos²,

Carollo³

et al. 2023

Sci Rep

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We conducted a study on the effects of fire on Rhamnidium elaeocarpum, a widely distributed woody species found in the Pantanal wetlands, using LC–MS metabolomics, total phenolic and tannin content analysis, and thermogravimetric behavior. We sampled individuals from four groups: No Fire, Fire 2019, Fire 2020, and APD 20 (individuals whose aerial parts had died during the 2020 fire event). We found that recent fires had no significant impact on the species' phenolic metabolism except for those in the fourth group. These specimens showed a decline in secondary metabolites due to leaching. The high levels of phenolics in R. elaeocarpum suggest that this species has a biochemical tolerance to the stress caused by seasonal fires. Metabolomic profiling revealed the presence of proanthocyanidin oligomers, which protect against oxidative stress and post-fire environmental disturbances. However, the passage of fire also led to a high incidence of toxic karwinaphthopyranone derivatives, which could be a concern for the species' medicinal use. Finally, the thermogravimetric analysis showed that the species is thermotolerant, with an intrinsic relationship between the secondary compounds and thermotolerance. Our research has deepened the comprehension of how fire affects the metabolic processes of woody plants. The challenge now lies in determining if the identified chemical changes are adaptive characteristics that evolved over time or merely transient responses to external environmental stimuli.

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Effect of peroxisomicine A₂and T 544 of the genusKarwinskiaon peroxisomes ofCandida boidinii

Cited by 8 publications

References 10 publications

Toxicity and Anticancer Potential of Karwinskia: A Review

Toxicity and Anticancer Potential of Karwinskia: A Review

Unraveling the Adaptive Chemical Traits of Rhamnidium elaeocarpum in Response to Fire and Environmental Factors in Pantanal Wetlands

Unraveling the adaptive chemical traits of Rhamnidium elaeocarpum Reissek in response to fire in pantanal wetlands

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