Effect of peripheral retinal ablation with cryotherapy versus diode laser photocoagulation on axial length in the growing rabbit eye

Axer‐Siegel, Ruth; Bourla, Dan; Kremer, I; Weinberger, Dov; Snir, Moshe

doi:10.1136/bjo.2005.082768

Cited by 15 publications

(8 citation statements)

References 21 publications

(18 reference statements)

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“…Whitmore et al reported that transcleral cryotherapy of the anterior retina in young rabbits slowed the growth of the anterior and posterior segments of rabbits eyes [211]. Later Axel-Siegel et al reported that cryotherapy of the peripheral retina in rabbits resulted in elongation of the eye [5]. …”

Section: Diverse Tissuementioning

confidence: 99%

Experimental cryosurgery investigations in vivo

2009

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Cryosurgery is the use of freezing temperatures to elicit an ablative response in a targeted tissue. This review provides a global overview of experimentation in vivo which has been the basis of advancement of this widely applied therapeutic option. The cellular and tissue-related events that underlie the mechanisms of destruction, including direct cell injury (cryolysis), vascular stasis, apoptosis and necrosis, are described and are related to the optimal methods of technique of freezing to achieve efficacious therapy. In vivo experiments with major organs, including wound healing, the putative immunological response following thawing, and the use of cryoadjunctive strategies to enhance cancer cell sensitivity to freezing, are described.

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Section: Diverse Tissuementioning

confidence: 99%

Experimental cryosurgery investigations in vivo

2009

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“…Randomized trials by Ng and Connolly showed laser photocoagulation to be as effective as cryotherapy [2][3][4][5]. Laser treatment was also found to be less destructive to the ocular coats with a significantly lower myopic refractive error and a functional visual difference that was maintained over 10 years [2,[6][7][8]. Conventional treatment strategy using laser photocoagulation is restricted to ablation of the avascular retina with the purpose of reducing the production of vasoproliferative factors (predominantly vascular endothelial growth factor) from this area.…”

Section: Introductionmentioning

confidence: 98%

Laser photocoagulation (810 nm diode) for threshold retinopathy of prematurity: a prospective randomized pilot study of treatment to ridge and avascular retina versus avascular retina alone

et al. 2010

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The purpose of this study was to compare the structural outcome of laser treatment to avascular retina and ridge versus laser treatment to avascular retina alone in cases with threshold retinopathy of prematurity (ROP). A prospective, randomized, interventional, comparative study of consecutive cases referred to a single tertiary center was considered here. 50 infants with bilateral symmetrical threshold ROP were recruited into this study over a period of 3 years. Threshold ROP was defined as per CRYO-ROP study. Perinatal history details for all patients including significant maternal history were recorded. One eye of each patient was randomized (Microsoft Excel 2000) to one of the two treatment groups--laser treatment to avascular retina (Group A) or laser treatment to avascular retina and ridge (Group B). Laser treatment was performed with a 810 nm diode laser (Iris Medical Instruments, Inc. Mountain View, CA, USA). Treatment was continued until regression of ROP. Structural outcome was assessed at a minimum follow-up of 6 months and was considered favorable or unfavorable as per the CRYO-ROP study criteria. An unfavorable outcome consisted of either (1) a retinal fold involving the macula; (2) any retinal detachment involving zone 1; or (3) a retrolental mass that obscured visualization of the posterior pole. Secondary outcome measures included the difference in time to regression of ROP and complications of treatment between the two treatment groups. 100 eyes of 50 infants received laser photocoagulation for threshold ROP after randomization (50 eyes in each group). Of these 50 infants, 20 (40%) were female and 30 (60%) were male. A significant proportion of the children (46%) were conceived as twins. The average birth weight was 1360 ± 326 g (range 750-2200 g). The mean gestational age at birth was 30.72 ± 1.6 weeks (range 26-36 weeks). Zone I disease was present in 14 (14%) eyes and zone II in the remaining 86 eyes (86%). Threshold stage retinopathy (CRYO-ROP criteria) extending 360° (12 clock hours) was present in 21 infants (42%), 5 contiguous clock hours of stage 3+ in 14 infants (28%) and intermediate range in the remaining 15 infants (30%). At 6 months follow-up, 3 eyes (6%) in group A and 1 eye (2%) in group B had an adverse structural outcome; however, the time to regression of retinopathy 2.98 ± 1.5 weeks in group A and 3.12 ± 1.1 in group B (P = 0.889) and the rate of complications such as retinal hemorrhage, 3 eyes in group A and 4 eyes in group B, was comparable. Zone I eyes showed equal incidence of favorable anatomical outcome (85.7%) in each group. Laser treatment to ridge was found to be safe and effective in the treatment of threshold ROP in this short-term pilot study; however, it needs to be ascertained whether this treatment has long-term advantages over conventional laser treatment to avascular retina, as well as the long-term benefits of treatment to ridge.

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“…A previous report (10) , that evaluated the influence of cryotherapy and diode laser photocoagulation on the growth of rabbit eyes, found areas of intraretinal peripheral macrocystoid edema and chronic inflammatory reaction. However, the authors performed between 15-20 cryo burns in each eye, with evaluation of histological sections after 10 weeks of follow up.…”

Section: Discussionmentioning

confidence: 99%

Assessment of the effect of intravitreal triamcinolone acetonide on the chorioretinal and vitreous inflammatory reaction to cryotherapy in rabbits

Figueirêdo

Hirata

Freitas

et al. 2012

Rev. bras.oftalmol.

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Effect of peripheral retinal ablation with cryotherapy versus diode laser photocoagulation on axial length in the growing rabbit eye

Abstract: Peripheral retinal cryotherapy causes a significantly greater elongation of the eye compared to diode laser photocoagulation in a rabbit model.

Cited by 15 publications

References 21 publications

Experimental cryosurgery investigations in vivo

Experimental cryosurgery investigations in vivo

Laser photocoagulation (810 nm diode) for threshold retinopathy of prematurity: a prospective randomized pilot study of treatment to ridge and avascular retina versus avascular retina alone

Assessment of the effect of intravitreal triamcinolone acetonide on the chorioretinal and vitreous inflammatory reaction to cryotherapy in rabbits

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