Effect of Periodontitis and Smoking on Blood Leukocytes and Acute‐Phase Proteins

Fredriksson, M.; Figueredo, Carlos Marcelo; Gustafsson, Anders; Bergström, Kurt; Åsman, B.

doi:10.1902/jop.1999.70.11.1355

Cited by 135 publications

(144 citation statements)

References 18 publications

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“…So it is plausible that CAL is not a suitable variable to investigate the association with periodontal disease and CRP levels. On the other hand, there are two studies that diagnosed periodontal disease with clinical attachment loss [13,28]. These studies reported a positive relation with CAL and CRP levels unlike the result of the present study.…”

Section: Discussioncontrasting

confidence: 99%

“…Elevated WBC in patients with periodontitis have been reported in some studies [19,27,28]. Kweider et al [19] were the first to report higher numbers of WBC in periodontitis (8.7 × 10 3 cells/μL in patients in comparison to 6.0 × 10 3 cell/μL in controls).…”

Section: Discussionmentioning

confidence: 94%

“…This discrepancy can be explained by confounding factors. One study [13] did not contain any confounding factors in the statistical analysis, which can confuse the association, whereas the other study [28] contained only age, gender, smoking, TG, cholesterol and BMI. Analysis of tooth loss and WBC counts might be explained in the same manner.…”

Section: Discussionmentioning

confidence: 99%

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Periodontal parameters and tooth loss were associated with Creactive protein and leukocyte counts in adult population aged 50 or older

et al. 2017

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·············································································································································································The association between periodontal disease and cardiovascular disease (CVD) has received considerable attention. This study investigated the correlation between tooth loss (the chief clinical parameter of periodontal disease) and systemic biomarkers of CVD, C-reactive protein (CRP) levels, and leukocyte (WBC) counts, in Koreans aged 50 years or older. A cross-sectional data of 5,322 participants was obtained from the 2008 to 2010 Dong-gu Study. Oral examination, survey questionnaire, physical examination, and biochemical assessments were performed. Oral examinations were completed in all dentate participants, and included the percentage of sites with ≥ 4 mm of probing depth (PD4%), clinical attachment level ≥ 4 mm (CAL4%), and bleeding on probing (BOP%). The number of missing teeth was categorized as 0-7, 8-15, 16-31, and edentulous. The serum CRP levels and WBC counts were assessed. Multivariate linear regression analysis was performed after adjusting for other potential confounders, to evaluate the association between the clinical parameters of periodontal disease, CRP levels and WBC counts. In the fully adjusted model, PD4%, BOP% and the number of missing teeth positively correlated with the CRP levels (p < 0.05), but CAL4% did not. The PD4%, CAL4%, and BOP% (p < 0.05) were concomitant with the WBC counts, but the number of missing teeth was not. The clinical parameters of periodontal disease and tooth loss directly correlated with CRP levels and WBC count in adults aged 50 years and above. This association indicates the potential significance of periodontal inflammatory burden for systemic inflammation.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

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Periodontal parameters and tooth loss were associated with Creactive protein and leukocyte counts in adult population aged 50 or older

et al. 2017

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“…Several mechanisms may explain the significant relationship between cigarette smoking and CRP concentrations. Cigarette smoking promotes inflammation in the oral cavity and airway tract, leading to periodontitis and chronic bronchitis (26,27). Also, free radicals generated by cigarette smoking can induce the production of inflammatory cytokines and consequently elevate CRP concentrations, as mentioned earlier (28).…”

Section: Discussionmentioning

confidence: 99%

Gender difference and determinants of C-reactive protein level in Korean adults

Lee

Shin

et al. 2009

Clinical Chemistry and Laboratory Medicine

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Background: C-reactive protein (CRP) has emerged as an important predictor for cardiovascular disease (CVD). To facilitate clinical and public health interventions, CRP thresholds have been defined as follows: low-risk (-1.0 mg/L), average-risk (1.0-3.0 mg/L), and high-risk ()3.0 mg/L). However, these cut-off thresholds are based on distributions in Western populations, and do not distinguish between men and women. Methods: We examined CRP distribution, gender difference, and determinants of CRP concentrations ranging from 0.02 mg/L to 10.0 mg/L, in 4923 Korean adults (2248 men; 2675 women) who received health checkups at Gangnam Severance Hospital from March 2006 to May 2007. Results: The distribution of CRP was highly skewed toward lower concentrations. CRP was higher in men than women, and the cut-off thresholds for the highrisk tertile of CRP concentrations corresponded to 1.01 mg/L in men and 0.62 mg/L in women, based on the current study population. Age, male gender, cigarette smoking, physical activity, body mass index, total cholesterol, high density lipoprotein cholesterol, g-glutamyltransferase, and uric acid were independently associated with CRP concentrations. Conclusions: CRP distribution and gender difference in Korean adults were found to be different from previous Western studies, although similar risk factors influence CRP concentrations. Our results suggest that ethnicity and gender specific cut-off thresholds

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“…Estos bajos niveles de bacteriemia pueden contribuir al incremento sistémico de la respuesta inmune e inflamatoria (40,41). La proximidad de dichos patóge-nos con el endotelio vascular, permite que tanto bacterias como moléculas proinflamatorias accedan a la circulación a través de las capas epiteliales quienes pueden haber perdido parte de su integridad por los procesos inflamatorios e infecciosos característicos de esta entidad (42).…”

Section: El Amiloide a Sérico Y Su Relación Con Enfermedad Periodontalunclassified

Proteína amiloide A sérica como marcador de inflamación sistémica en pacientes con enfermedad periodontal

Romero-Sánchez

Uribe-Rivera

Velandia-Quintero

et al. 2013

Avances en Periodoncia

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RESUMENLa respuesta de fase aguda es la reacción inflamatoria inmediata del huésped que contrarresta desafíos como lesión de los tejidos, infección y trauma. Los reactantes de fase aguda que han recibido mayor atención son: proteína C reactiva (PCR), componente sérico P, proteína amiloide sérica (AAS) y alfa 1 ácido glicoproteína. Se ha establecido en décadas pasadas que las proteínas de fase aguda no solamente aparecen en procesos de enfermedades severas y agudas si no también en condiciones crónicas. El AAS es el principal componente de las placas amiloideas secundarias depositadas en los órga-nos principales como consecuencia de la enfermedad inflamatoria crónica. La familia de la AAS contiene un número de diferentes apolipoproteínas expresadas, las cuales son sintetizadas principalmente por el hígado. El aumento de AAS es considerado un marcador sistémico de enfermedades inflamatorias agudas y enfermedades crónicas que afecta la composición y función de lipoproteínas de alta densidad (HDL). Se ha demostrado que la intervención terapéutica en la periodontitis disminuye la inflamación y reduce el AAS significativamente y por consiguiente puede reducir el riesgo de enfermedad cardiovascular (ECV). Además es posible que pacientes con periodontitis, que presentan un aumento de la PCR y el AAS, representen un subgrupo específico en términos de riesgo para la aterosclerosis y enfermedad cardiovascular en comparación a los pacientes con periodontitis cuyos niveles plasmáticos de AAS son normales, estableciendo así una relación directa entre la enfermedad periodontal y los niveles de AAS.

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Effect of Periodontitis and Smoking on Blood Leukocytes and Acute‐Phase Proteins

Abstract: In general, the combination of periodontitis and cigarette smoking alters the parameters studied. The effects of periodontitis on CRP and IgG2 means that periodontal lesions may also leak agents, priming the peripheral neutrophils to increased CL.

Cited by 135 publications

References 18 publications

Periodontal parameters and tooth loss were associated with Creactive protein and leukocyte counts in adult population aged 50 or older

Periodontal parameters and tooth loss were associated with Creactive protein and leukocyte counts in adult population aged 50 or older

Gender difference and determinants of C-reactive protein level in Korean adults

Proteína amiloide A sérica como marcador de inflamación sistémica en pacientes con enfermedad periodontal

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