Effect of pegylated nano niosomal 2, 4- dichlorophenoxyacetic acid on intracellular taxol production

Abstract

Nowadays, studies about yew tree as a main source of taxol (anticancer drugs) is being expanded rapidly. In the last few years, taxol is being isolated from the bark of Taxus brevifolia as the species of yew tree, containing very low amount (approximately 0.01%) .Taxol is diterpenoid amide and can be produced by different approaches, suspended cell culture is a method through which taxol can be produced. In this study, 2,4-dichlorophenoxy acetic acid(2,4-D) was nano niosomated in order to deliver the plant hormone to the cells under cultivation. The result demonstrated that the amount of taxol was significantly increased when the cell culture was exposed to pegylated nano niosomal 2 , 4dichlorophenoxy acetic acid(2,4-D) .