Effect of Patient-Optimized Doses of Tamsulosin on Erectile Function in Men With Erectile Dysfunction and Lower Urinary Tract Symptoms

Jo, Hyun Wook; Yoo, Dong Gon; Ju, Hyun Taek; Whang, Ha Wook; Park, Jinsung; Kim, Eun Tak; Kim, Dae Kyung; Woo, Seung Hyo

doi:10.4111/kju.2013.54.2.100

Cited by 6 publications

(2 citation statements)

References 29 publications

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“…Tamsulosin has emerged as a treatment option for BPH and LUTS owing to its different mode of action. One notable advantage of this alpha-1-blocker is to not interfere with erectile function or testosterone levels of patients ( 22 , 23 ). However, in some patients, combination therapy (with dutasteride and tamsulosin) is necessary to adequately treat BPH and LUTS.…”

Section: Discussionmentioning

confidence: 99%

Effects of dutasteride and tamsulosin on penile morphology in a rodent model

et al. 2023

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Purpose To evaluate the penile morphology after the isolated and combined administration of dutasteride and tamsulosin in a rodent model. Materials and Methods Forty male rats were assigned into the following groups: Control group (C, receiving distilled water, n=10); Dutasteride group (D, receiving 0.5 mg/Kg/day of dutasteride, n=10); Tamsulosin group (T, receiving 0.4 mg/Kg/day of tamsulosin, n=10); and Dutasteride associated with Tamsulosin group (DT, receiving both drugs n = 10). All drugs were administered via oral gavage. After 40 days, the animals were submitted to euthanasia and their penises were collected for histomorphometric analyses. Data were compared using one-way ANOVA followed by Bonferroni’s post-test, considering p<0.05 as significant. Results The sinusoidal space and smooth muscle fiber surface densities (Sv), and the cross-sectional penile areas of rats in groups D, T and DT were reduced in comparison to controls with the most notable reductions in the combined therapy group. The connective tissue and elastic system fibers Sv were augmented in groups D, T and DT in comparison with the control group, again with the most pronounced changes observed in animals receiving the combined therapy. Conclusion Both treatments with dutasteride or tamsulosin promoted penile morphometric modifications in a rodent model. The combination therapy resulted in more notable modifications. The results of this study may help to explain the erectile dysfunction observed in some men using these drugs.

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Section: Discussionmentioning

confidence: 99%

Effects of dutasteride and tamsulosin on penile morphology in a rodent model

et al. 2023

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“…Recently, changes in sexual function before and after the treatment of benign prostatic hyperplasia have attracted attention. Previous studies have reported that tamsulosin, which is used as a primary therapeutic agent for benign prostatic hyperplasia, was effective in the improvement of sexual function as well as the improvement of lower urinary tract symptoms (LUTS) [ 1 , 2 , 3 ]. However, studies on the effect of tamsulosin on ejaculation have reported that tamsulosin had inhibitory effects in the emission phase of ejaculation, including decreased ejaculatory volume [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Tamsulosin on Premature Ejaculation in Men with Benign Prostatic Hyperplasia

Choi

Hwa

Kam

et al. 2014

World J Mens Health

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PurposePrevious studies have revealed that tamsulosin is effective in improving lower urinary tract symptoms (LUTS) and erectile functioning but has some inhibitory effects on ejaculation, including decreased ejaculatory volume. However, these inhibitory effects on ejaculation can be beneficial to patients with premature ejaculation (PE). Therefore, this study was conducted to understand the effect of tamsulosin on PE in men with benign prostatic hyperplasia.Materials and MethodsTwenty-nine patients who visited with LUTS were categorized into 2 groups of LUTS-only patients (n=12) and LUTS combined with PE (LUTS+PE) patients (n=17), and 0.4 mg of tamsulosin was administered to the patients of both groups for 12 weeks. Comparative analyses of before and after the treatment were conducted for calculating the International Prostate Symptom Score (IPSS), International Index of Erectile Function-5 (IIEF-5), intravaginal ejaculatory latency time (IELT), premature ejaculation diagnostic tool (PEDT), and premature ejaculation profile (PEP). The patients with an IPSS score of 8 or higher were determined as LUTS patients, and the patients with IELT of less than 2 minutess and a PEDT score of 9 or higher were determined as PE patients.ResultsAfter treatment, the IPSS score significantly decreased in both groups. There was no statistically significant change in the PEDT for the LUTS group, but there was a significant decrease in PEDT (p=0.012; from 12.1±3.31 to 8.4±4.49) in the LUTS+PE group.ConclusionsTamsulosin not only has a treatment effect for LUTS but also improves the PE of LUTS+PE patients. Therefore, further studies are needed to confirm the effects of tamsulosin on PE.

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