Treatment of erectile dysfunction: New targets and strategies from recent research

Decaluwé, Kelly; Pauwels, Bart; Boydens, Charlotte; Voorde, Johan Van de

doi:10.1016/j.pbb.2013.11.024

Cited by 17 publications

(27 citation statements)

References 221 publications

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“…In this connection, the upregulation of the production of NO and the increase of the cGMP levels are valuable strategies in the strengthening of corpus cavernosum smooth muscle relaxation [27]. Besides this, other potential NO-cGMP-independent vasorelaxation routes have been enlightened through the years and are now being investigated.…”

Section: Alternative Targetsmentioning

confidence: 99%

“…In this sense, herbal supplements are encountering a renewed interest, since they have always been popular in many countries; their easy availability is one of the points to consider among the pros. The mechanism of action of most of these natural remedies is quite unclear, but it often seems to involve a stimulating effect on the previously described NO-cGMP signaling pathway [27].…”

Section: The Old Made New: Traditional Medicinementioning

confidence: 99%

“…Indeed, oxidative stress is demonstrated to be involved in the pathophysiology of ED, and during the years, it became clearer that polyphenols can act as antioxidants, affecting NOcGMP pathway and also angiogenesis; this means that these compounds can be representative of a new, potential, effective approach for treating ED [27]. Among polyphenol-containing natural derivatives, a sui generis one can be considered to be red wine.…”

Section: Polyphenols: Antioxidants For Treating Edmentioning

confidence: 99%

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The Old Made New: Natural Compounds against Erectile Dysfunction

Pavan

Mucignat‐Caretta

Redaelli

et al. 2015

Archiv der Pharmazie

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The interest toward sex-related diseases keeps growing through the years. In this review, we focus our attention on erectile dysfunction (ED), a condition that caught much attention especially after the introduction on the market of phosphodiesterase 5 inhibitors such as the well-known sildenafil. Here, we briefly describe both the etiology of ED and the available treatments, examining then extensively some natural derivatives that, coming from traditional medicine, could represent promising starting points for the development of alternative remedies. In fact, herbal remedies from several parts of the world have been traditionally known for long, and were recently reconsidered and are now being studied to demonstrate their eventual potential in the treatment of ED. Among the various examples reported in the literature and reviewed here, plants and extracts containing polyphenols—especially a class of compounds called kraussianones—appear to be particularly effective and promising against ED.

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Section: Alternative Targetsmentioning

confidence: 99%

Section: The Old Made New: Traditional Medicinementioning

confidence: 99%

Section: Polyphenols: Antioxidants For Treating Edmentioning

confidence: 99%

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The Old Made New: Natural Compounds against Erectile Dysfunction

Pavan

Mucignat‐Caretta

Redaelli

et al. 2015

Archiv der Pharmazie

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“…Erectile dysfunction (ED) in particular is typically presented in older men, but has been increasing in ED is a complex problem that can have both physical and psychologic etiologies. Although the physical factors that lead to ED have promising treatments [5], the psychologic factors associated with ED are multifaceted and require more research. Military populations are particularly vulnerable to ED and other SFPs because of various potential risk factors, including exposure to trauma, immersion in a masculine culture, and high daily performance demands [6][7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Genital Image, Sexual Anxiety, and Erectile Dysfunction Among Young Male Military Personnel

Wilcox

Redmond

Davis

2015

The Journal of Sexual Medicine

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Introduction More than a third of young military personnel report experiencing some level of erectile dysfunction (ED). Preoccupation with body image, particularly genitals, is a distraction that can influence sexual anxiety (SA) and sexual functioning problems (SFPs), particularly ED. Aims This study assessed the relationships between male genital self-image (MGSI), SA, and ED in a sample of male military personnel age 40 or younger. Methods Data were from a larger study on SFPs in military populations. This sample consisted of 367 male military personnel age 40 or younger. Hierarchical regression analyses and process modeling using mediation analysis were performed to examine the effects of MGSI on ED with SA as an intermediate variable. We predicted that SA would mediate the relationship between MGSI and ED. Main Outcome Measures ED severity was assessed with the International Index of Erectile Function. MGSI was assessed using the MGSI Scale. SA was assessed with the SA subscale of the Sexual Needs Scale. Results As hypothesized, greater satisfaction with MGSI was predictive of significantly lower SA (F[8, 352] = 4.07, P = 0.001) and lower ED (F[8, 352] = 13.20, P = 0.001). Lower levels of SA were predictive of lower levels of ED (F[8, 354] = 21.35, P < 0.001). Additionally, results also revealed a significant indirect effect of MGSI on ED through SA (b = −0.07, standard error = 0.03, confidence interval = [−0.14,−0.02], P < 0.05), indicating mediation of MGSI on ED via SA. Conclusions This study underscores the complex etiologic basis of SFPs, particularly ED, and highlights the importance of considering psychologic contributors to ED, such as SA and MGSI. Strategies aimed at reducing SA may be useful in improving ED in young military populations and are worth considering as complements to strategies that improve SFPs.

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“…Phosphodiesterase type 5 inhibitors (PDE5i) have revolutionized ED treatment, although there are limitations in their use (e.g., diabetes and nerve injury patients often respond poorly to PDE5i). In the last decade, several new treatment strategies for the treatment of ED have been pursued, aiming at treating underlying microvascular abnormalities, restoring smooth muscle contractility, preventing cavernosal fibrosis, promoting endothelial revascularization, modulating neurohumoral pathways, and regenerating new penile tissue [3].…”

mentioning

confidence: 99%

Introductory Chapter: Sexual Dysfunction - Introduction and Perspective

Olivier¹

2017

Sexual Dysfunction

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Psychiatric Association [1] gives the following classifications of sexual dysfunctions: delayed ejaculation, erectile disorder, female orgasmic disorder, female sexual interest/arousal disorder, genito-pelvic pain/penetration disorder, male hypoactive sexual desire disorder, premature (early) ejaculation, substance-/medication-induced sexual dysfunction, other specified sexual dysfunction, and unspecified sexual dysfunction. It is evident that sexual dysfunctions constitute a heterogeneous group of disorders. They are characterized by clinically significant disturbances to respond sexually or experience sexual pleasure. Determining the character of the sexual dysfunction is a complex issue, which needs extensive clinical and psychological/ psychiatric expertise in order to come to a correct clinical judgment and includes partner and relationship factors, individual vulnerability, psychiatric comorbidity, stressors, and cultural, religious, and medical factors.Sexual functioning involves a complex interaction of biological, sociocultural, and psychological factors, which makes a clear diagnosis sometimes rather difficult. In any case, problems should be ruled out that are caused by interfering factors, like drugs, medicines, a medical condition (e.g., pelvic nerve damage) or external factors like partner violence, or other severe stressors.

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Treatment of erectile dysfunction: New targets and strategies from recent research

Cited by 17 publications

References 221 publications

The Old Made New: Natural Compounds against Erectile Dysfunction

The Old Made New: Natural Compounds against Erectile Dysfunction

Genital Image, Sexual Anxiety, and Erectile Dysfunction Among Young Male Military Personnel

Introductory Chapter: Sexual Dysfunction - Introduction and Perspective

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