Effect of particulate porous hydroxyapatite on osteoinduction of demineralized bone autografts in experimental reconstruction of the rat mandible

Comparison of Biomaterial Implants in the Dental Socket: Histological Analysis in Dogs

“…This result is in accord with other studies using this model. 14,20,21 Considering the analysis time (4, 8, and 28 weeks), no inflammatory response was observed with this biomaterial, although a foreign body reaction was presented. Normal healing requires the presence of a periodontal ligament because the periodontal ligament cells proliferate and migrate into the center of the extraction socket where they differentiate into osteoblasts that have become involved in the formation of new bone.…”

“…After 8 weeks, all extraction alveolar sockets were filled by lamellar bone, and after 28 weeks, extraction alveolar sockets showed compact bone in the control group. 9,11,15,17,21 The reason for the disparate results may be explained by the different sites of implantation, variation in the animal species, and periods of analysis. 11,27 However, Gauthier and colleagues 9 showed similar results between the test and control groups, although in this study, extraction sockets were debrided with a dental curette to remove the periodontal ligament, which consequently interfered with the normal sequence of alveolar healing.…”

“…The major disadvantages of ABG are donor site morbidity, limitations on the quantity of grafted materials, and high cost. 12,13,16,17,[19][20][21][22] BGs are a class of biomaterials based on amorphous silicate compounds. Therefore, there is a critical need for the development of bone substitute materials that match the properties of bone without the drawbacks of autografts or allografts, that can be supplied at any time, in any amount, and at lower costs.…”

Treatment of contaminated bone defects with clindamycin‐reconstituted bone xenograft‐composites

“…Effective anti‐infection action is another important function of the C‐RBX‐C matrix. Staphylococcus aureus is reportedly the main pathogen in bone infection 34, 35. Clindamycin has excellent in vitro activity against most strains of Staphylococcus aureus and is not inactivated by β‐lactamase.…”

The Production of Porous Hydroxyapatite Scaffolds with Graded Porosity by Sequential Freeze-Casting

“…Among them, hydroxyapatite (HA, Ca 10 (PO 4 ) 6 (OH) 2 ) is one of the main components of bone and has the ability to promote osteoconduction [7]. Therefore, HA has been used in several ways, including as a coating material for enhancing the biocompatibility of pure materials [7,8,9,10,11], bone cement to compensate for bone loss during orthopedic surgery [12,13,14,15], and artificial bone scaffolds to replace autografts or allografts, which have limited donor availability [16,17]. However, dense HA has a low resorption rate under physiological conditions, which can result in poor fixation between the scaffold and the newly generated bone [7].…”