Effect of parental arterial stiffness in offspring: the Kailuan study

Wu, Yuntao; Liu, Qian; Ma, Yu; Zhao, Xiaohong; Zhao, Haiyan; Song, Mingzhu; Sun, Junyan; Wang, Xingyu; Wu, Shouling

doi:10.1097/hjh.0000000000002984

Cited by 6 publications

(4 citation statements)

References 35 publications

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“…The Kailuan Study is a prospective cohort study conducted in the community of Tangshan, China. The relevant design of the Kailuan study has been described in detail in previous articles [ 10 – 12 ]. Here, young and middle-aged participants were defined as males aged less than 55 years or females aged less than 65 years [ 13 ].…”

Section: Methodsmentioning

confidence: 99%

Association of the triglyceride-glucose index with early-onset atherosclerotic cardiovascular disease events and all-cause mortality: a prospective cohort study

Hou,

Qi,

Han

et al. 2024

Cardiovasc Diabetol

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Background The association between the triglyceride glucose (TyG) index and the risk of early-onset atherosclerotic cardiovascular disease (ASCVD) events or all-cause mortality in young and middle-aged people is not fully elucidated. Methods The present study included 64,489 young and middle-aged people who participated in the 2006 Kailuan Study physical examination. Multivariate Cox proportional hazards models and restricted cubic spline curves were used to assess the association of TyG index with early-onset ASCVD events and all-cause mortality. Results During a median of 11-year follow-up, 1984 (3.08%) participants experienced at least one ASCVD event and 1,392 (2.16%) participants experienced all-cause death. A higher TyG index was significantly associated with a higher risk of early-onset ASCVD events (HR: 1.61, 95% CI 1.38–1.89) and all-cause mortality (HR: 1.39, 95% CI 1.17–1.65), respectively. For each unit increase in TyG index, the risk of early-onset ASCVD events increased by 20%. In addition, there was a non-linear association between the TyG index and early-onset ASCVD events (P for non-linear < 0.01), and a linear association between TyG index and all-cause mortality (P for non-linear = 0.476). Conclusions A higher TyG index is significantly associated with an increased incidence of early-onset ASCVD events and all-cause mortality in a young and middle-aged population from North China.

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Section: Methodsmentioning

confidence: 99%

Association of the triglyceride-glucose index with early-onset atherosclerotic cardiovascular disease events and all-cause mortality: a prospective cohort study

Hou,

Qi,

Han

et al. 2024

Cardiovasc Diabetol

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“…Diabetes status was based on receiving hypoglycemic drugs, a self-reported history of diagnosed diabetes, or FBG ≥ 7.0 mmol/L [ 23 ]. The remaining detailed design and basic description were obtained from published literature [ 24 ].…”

Section: Methodsmentioning

confidence: 99%

Relationship between early-onset stroke and triglyceride-glucose index among young Chinese adults

Zhao

Liu

et al. 2023

Lipids Health Dis

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Background The triglyceride–glucose index (TyG index), an alternative indicator of peripheral insulin resistance (IR), is associated with cardiovascular disease (CVD) in the general population. The aim of this research was to determine the correlation between early-onset stroke and the TyG index among young Chinese adults. Methods Participants (age ≤ 40 years) who attended their first physical examination in Kailuan General Hospital or its 11 subsidiary hospitals between 2006 and 2012 were enrolled. The subjects were divided into four equal points according to the quartile of the TyG index, with the lowest quartile (Q1) as the reference group. A Cox proportional hazard model was employed to assess the correlation between early-onset stroke incidence and the TyG index. Restricted cubic spline analysis was further conducted to examine nonlinear associations. The TyG index was calculated as Ln [Triglyceride (TG, mg/dL) × Fasting Blood Glucose (FBG, mg/dL)/2]. Results Overall, 35,999 subjects met the inclusion criteria. Their mean age was 30.8 ± 5.7 years, and 77.1% of subjects were males. During a median observation period of 11 years, 281 stroke events occurred (62 hemorrhagic strokes and 219 ischemic strokes). Compared to the Q1 group (as the lowest group), subjects in groups Q2-Q4 had significantly higher risks of early-onset stroke (P < 0.05) after adjustment for relevant confounders in the Cox proportional hazards model. Similar results were consistent with ischemic stroke. However, no significant associations were observed between the risk of hemorrhage and the baseline TyG index. The restricted cubic splines revealed that the risk of stroke progressively increased with a high TyG index ≥ 8.41. Conclusions The TyG index may be a major risk factor for early-onset stroke among young Chinese adults. A TyG index ≥ 8.41 can be used as an indicator for screening high-risk stroke groups.

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“…VP-1000 Plus vascular screening device 2 [356,323] VaSera VS-1500 vascular screening system 1 [353] BOSO-ABI System 100 device 1 [359] BP-203RPEIII networked arterial stiffness detection device 1 [331] Mylab90 device 1 [125] Estimated PWV using age and mean blood pressure 1 [326] Omron Colin device 1 [325] Volume plethysmography device 1 [322] SOMNOscreen plus device 1 [349] DOI: 10.1159/000527765…”

Section: Analytic Considerationsmentioning

confidence: 99%

Assessments of Perfusion, Blood Flow, and Vascular Structure in Ambulatory Subjects: Guidance for Translational Research Scientists

et al. 2023

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Research involving human subjects in ambulatory settings is a critical link in the chain comprising translational research, spanning preclinical research to human subject and patient cohort studies. There are presently a wide array of techniques and approaches available to investigators wishing to study blood flow, perfusion, and vascular structure and function in human subjects. In this multi-sectioned review, we discuss capillaroscopy, carotid intima-media thickness, flow-mediated dilation, laser Doppler flowmetry, near-infrared spectroscopy, peripheral arterial tonometry, pulse wave velocity, retinal fundus imaging, and vascular plethysmography. Each section contains a general overview and the physical basis of the technique followed by a discussion of the procedures involved and the necessary equipment, with attention paid to specific requirements or limitations. Subsequently, we detail which aspects of vascular function can be studied with a given technique, the analytical approach to the collected data, and the appropriate application and limitation(s) to the interpretation of the data collected. Finally, a modified scoping review provides a summary of how each assessment technique has been applied in previous studies. It is anticipated that this review will provide an efficient source of information and insight for preclinical investigators seeking to add translational aspects to their research programs.

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Effect of parental arterial stiffness in offspring: the Kailuan study

Cited by 6 publications

References 35 publications

Association of the triglyceride-glucose index with early-onset atherosclerotic cardiovascular disease events and all-cause mortality: a prospective cohort study

Association of the triglyceride-glucose index with early-onset atherosclerotic cardiovascular disease events and all-cause mortality: a prospective cohort study

Relationship between early-onset stroke and triglyceride-glucose index among young Chinese adults

Assessments of Perfusion, Blood Flow, and Vascular Structure in Ambulatory Subjects: Guidance for Translational Research Scientists

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