Effect of palmitoylethanolamide–polydatin combination on chronic pelvic pain associated with endometriosis: Preliminary observations

Indraccolo, Ugo; Barbieri, F

doi:10.1016/j.ejogrb.2010.01.008

Cited by 69 publications

(64 citation statements)

References 19 publications

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“…For dyspareunia there was a significant reduction at day 30, which remained constant until the end of the study (p < 0.0132). The reduction in pain intensity was paralleled by a statistically significant (p < 0.0176) reduction in analgesics use [145].…”

Section: Effect Of Pea On Visceral Painmentioning

confidence: 70%

New Targets in Pain, Non-Neuronal Cells, and the Role of Palmitoylethanolamide

Hesselink¹

2012

TOPAINJ

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Persistent pain in neuropathic conditions is often quite refractory to conventional analgesic therapy, with most patients obtaining, at best, only partial relief of symptoms. The tendency still exists to treat these complex pains with one or a combination of two analgesics at the most. Given the complex nature of the underlying pathogenesis, this approach more often than not fails to produce a meaningful improvement. New targets are therefore badly needed. In this regard non-neuronal cells -glia and mast cells in particular -are emerging as new targets for the treatment of neuropathic pain. An extensive preclinical database exists showing that the naturally occurring fatty acid amide palmitoylethanolamide is endowed with anti-inflammatory activity, and clinical trials assessing the efficacy and safety of palmitoylethanolamide in neuropathic pain have been successful in generating proof-of-concept for treatment in man. Here I will review salient preclinical and clinical evidence supporting non-neuronal cells as viable targets in the treatment of neuropathic pain. This will be followed by a discussion of recent proof-of-concept clinical trials demonstrating the efficacy and safety of palmitoylethanolamide in the treatment of various neuropathic pain states.

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Section: Effect Of Pea On Visceral Painmentioning

confidence: 70%

New Targets in Pain, Non-Neuronal Cells, and the Role of Palmitoylethanolamide

Hesselink¹

2012

TOPAINJ

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“…6,10,12,13,15,[17][18][19][20][22][23][24][26][27][28]31,32 The main results of these studies are summarized in Table 3.…”

Section: Resultsmentioning

confidence: 98%

“…Of the 17 studies that evaluated the influence of medication on decreasing pain levels, seven evaluated one drug alone 6,13,20,[26][27][28]32 and 10 evaluated drugs in combination. 10,12,15,[17][18][19][22][23][24]31 Thus, 3 studies employed contraceptives; 24,26,27 10 used isolated progestins; 10,12,13,15,17,19,20,22,23,28 5 used GnRHa, 6,10,22,24,32 one used danazol 23 and 4 used aromatase inhibitors. 12,15,19,22 The use of aromatase inhibitors for the treatment of endometriosis and its associated symptoms is justified by the fact that endometriotic tissue over-expresses aromatase, an enzyme key for the production of estrogen, noting that endometriosis is an estrogen-dependent gynecological condition.…”

Section: Discussionmentioning

confidence: 99%

“…Two studies have evaluated the combination of N-palmitoyl ethanolamine and transpolydatin/polydatin, drugs that act on inflammation, in the treatment of pain associated with endometriosis. 18,31 Polydatin is a resveratrol glycoside that has antioxidant activities. Therefore, the combination of these drugs work on the inflammatory processes and oxidative stress involved in the development of endometriosis.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of endometriosis-associated pain and influence of conventional treatment: a systematic review

Marqui

2015

Rev. Assoc. Med. Bras.

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Financial support: none Conflict of interest: noneEndometriosis is a chronic gynecological disease characterized by sustained painful symptoms that are responsible for a decline in the quality of life of sufferers. Conventional treatment includes surgical and pharmacological therapy aiming at reducing painful symptoms. This study aimed to evaluate pain levels in women with endometriosis, focusing on the influence of conventional treatment in controlling this variable. To do so, a literature search was conducted in the Medline/Pubmed databases, with 119 scientific articles found. After applying the inclusion and exclusion criteria, 27 were selected for reading and elaboration of this review. Thus, 9 studies evaluated the contribution of surgery, 17 the use of drugs to reduce pain levels in patients with endometriosis and one assessed surgical and medical treatment. The main results of these searches are presented and discussed in this revision. Surgery and the use of drugs provided reduced pain scores in patients with endometriosis but nevertheless exhibit disadvantages, such as risk of recurrence and side effects, respectively. Treatment of endometriosis is, therefore, a challenge for gynecologists and patients, as they must select the best therapeutic approach for this disease.However, improved quality of life in these patients has been obtained with the use of conventional treatment.

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“…In Italy and other European states, products based on PEA are approved as therapeutics classified as "dietary foods for special medical purposes". The combination of micronized PEA and polydatin, in particular, provides significant and long-lasting relief of pelvic pain symptomatology (Table 3) [100][101][102][103][104][105]. Given the optimal safety profile of PEA, products based on this fatty acid amide may find utility as tools to control pain in pelvic disorders associated to CPP, as well as co-morbid anxiety and depression.…”

Section: Depression Inflammation and Pelvic Pain Management: Mcs As mentioning

confidence: 99%

Inflammation and Chronic Pelvic Pain: A Biological Trigger for Depression in Women?

Graziottin¹,

Skaper²,

Fusco³

2014

J Depress Anxiety

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Effect of palmitoylethanolamide–polydatin combination on chronic pelvic pain associated with endometriosis: Preliminary observations

Cited by 69 publications

References 19 publications

New Targets in Pain, Non-Neuronal Cells, and the Role of Palmitoylethanolamide

New Targets in Pain, Non-Neuronal Cells, and the Role of Palmitoylethanolamide

Evaluation of endometriosis-associated pain and influence of conventional treatment: a systematic review

Inflammation and Chronic Pelvic Pain: A Biological Trigger for Depression in Women?

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