Effect of pain neuroscience education after breast cancer surgery on pain, physical, and emotional functioning: a double-blinded randomized controlled trial (EduCan trial)

Dams, Lore; Gucht, Elien Van der; Devoogdt, Nele; Smeets, Ann; Bernar, Koen; Morlion, Bart; Godderis, Lode; Haenen, Vincent; Vrieze, Tessa De; Fieuws, Steffen; Moloney, Niamh; Wilgen, Paul van; Groef, An De

doi:10.1097/j.pain.0000000000002838

Cited by 12 publications

(18 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A0: baseline assessment, A1: postoperative assessment, A4: 4 months post‐surgery assessment (=end of intensive phase), A6: 6 months post‐surgery assessment, A8: 8 months post‐surgery assessment, A12: 12 months post‐surgery assessment, and A18: 18 months post‐surgery assessment (end of maintenance phase). Missing data and reasons are shown for the primary outcome measure of the EduCan trial (pain‐related disability evaluated with Pain Disability Index; Dams et al, 2022). However, there are more missing data for the outcome measure QST in this article.…”

Section: Resultsmentioning

confidence: 99%

“…The present manuscript reports on secondary analyses of the EduCan Trial. Results on the primary analysis are reported elsewhere (Dams et al, 2022). Findings were reported in accordance with the CONsolidated Standards of Reporting Trials (CONSORT) guidelines (Moher et al, 2012; Schulz et al, 2010).…”

Section: Methodsmentioning

confidence: 99%

“…A power calculation was performed by the Leuven Biostatistics and statistical Bioinformatics Centre (L‐BioStat) for the EduCan trial project for the primary outcome pain‐related disability, evaluated with the Pain Disability Index of which results are published elsewhere (Dams et al, 2022). The current study analyzed the secondary outcome parameters of this randomized trial.…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Effectiveness of pain neuroscience education on somatosensory functioning after surgery for breast cancer: A double‐blinded randomized controlled trial

Dams

Gucht

Haenen

et al. 2023

The Anatomical Record

View full text Add to dashboard Cite

Pain is one of the most prevalent and long‐term adverse effects described by people who have undergone breast cancer surgery. Non‐helpful perceptions and thoughts about pain may contribute to the transition of acute to persistent pain. Adding educational interventions to the current physical therapy program in this population may help to improve or prevent persistent pain. Pain neuroscience education (PNE) is a type of educational intervention that addresses the experience of pain in a broader sense by explaining pain not only from a biomedical perspective, but also from a psychological and social perspective. A double‐blinded randomized controlled trial (EduCan trial) investigated whether PNE, in addition to a standard physiotherapy program immediately after surgery for breast cancer, was more effective on somatosensory functioning in the short (4 months postoperatively) and long term (18 months postoperatively), than providing a biomedical explanation for pain. Somatosensory functioning was evaluated using a self‐reported questionnaire as well as a comprehensive quantitative sensory testing evaluation. The findings of this study revealed that adding six sessions of PNE to a standard physical therapy program (n = 184) did not result in a significantly different course of somatosensory functioning up to 18 months postoperatively as compared to biomedical pain education. These findings provide an interesting basis for future research into who should receive PNE after surgery for breast cancer (e.g., patient profiling or phenotyping) and how we can tailor it to the individual to increase its effectiveness.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Effectiveness of pain neuroscience education on somatosensory functioning after surgery for breast cancer: A double‐blinded randomized controlled trial

Dams

Gucht

Haenen

et al. 2023

The Anatomical Record

View full text Add to dashboard Cite

show abstract

“…PNE covers topics such as acute versus chronic pain, the purpose of acute pain, the origins of acute pain, the transition to chronic pain and potential factors that sustain chronic pain, explained from a biopsychosocial view rather than a pure patho-anatomical output, and as a consequence, patients’ illness perceptions also change to the biopsychosocial perspective 23 24. Previous single-arm studies using PNE in BCSs showed positive results on central sensitisation symptoms25 26 and pain-related function and quality of life,26 whereas results in a large randomised controlled trial comparing PNE combined with physical activity with biomedically focused education did not find any significant differences in different pain-related outcomes 27. However, the latter trial was conducted in BCSs who were not preselected for having significant pain, which might explain the absence of an added value of the respective PNE-based intervention 27.…”

Section: Introductionmentioning

confidence: 99%

Effect of perceived injustice-targeted pain neuroscience education compared with biomedically focused education in breast cancer survivors: a study protocol for a multicentre randomised controlled trial (BCS-PI trial)

Roose,

Huysmans,

Leysen

et al. 2024

BMJ Open

Self Cite

View full text Add to dashboard Cite

IntroductionCurrent treatments for pain in breast cancer survivors (BCSs) are mostly biomedically focused rather than biopsychosocially driven. However, 22% of BCSs with pain are experiencing perceived injustice, which is a known predictor for adverse pain outcomes and opioid prescription due to increased maladaptive pain behaviour. Educational interventions such as pain neuroscience education (PNE) are suggested to target perceived injustice. In addition, motivational interviewing can be an effective behavioural change technique. This trial aims to examine whether perceived injustice-targeted PNE with the integration of motivational interviewing is superior to biomedically focused pain education in reducing pain after 12 months in BCS with perceived injustice and pain. In addition, improvements in quality of life, perceived injustice and opioid use are evaluated, and a cost-effectiveness analysis will finally result in a recommendation concerning the use of perceived injustice-targeted PNE in BCSs with perceived injustice and pain.Methods and analysisThis two-arm multicentre randomised controlled trial will recruit female BCS (n=156) with pain and perceived injustice. Participants will be randomly assigned to perceived injustice-targeted PNE or biomedically focused pain education in each centre. Both interventions include an online session, an information leaflet and three one-to-one sessions. The primary outcome (pain), secondary outcomes (quality of life, perceived injustice and outcomes for cost-effectiveness analysis) and explanatory outcomes (pain phenotyping, sleep, fatigue and cognitive-emotional factors) will be assessed at baseline and at 0, 6, 12 and 24 months postintervention using self-reported questionnaires online. Treatment effects over time will be evaluated using linear mixed model analyses. Additionally, a cost-utility analysis will be done from a healthcare payer and societal perspective.Ethics and disseminationThe ethical agreement was obtained from the Main Ethics Committee (B.U.N.1432020000068) at the University Hospital Brussels and all other participating hospitals. Study results will be disseminated through presentations, conferences, social media, press and journals.Trial registration numberNCT04730154.

show abstract

“…It typically involves elucidating the etiological underpinnings and remedial strategies of pain sensitization, promoting patient engagement in rehabilitative exercise and cognitive modi cations. These components collectively contribute to enhanced pain control, improved quality of life, and augmented physical functionality ,Dams 2023]. However, extant PNE frameworks are primarily con gured for chronic pain management and lack speci city for surgical contexts [Landry 2020].…”

Section: Introductionmentioning

confidence: 99%

The effect of peri-operative pain neuroscience education on post-operative pain and recovery in adult patients receiving laparoscopic inguinal hernia repair---A prospective randomized controlled trial

Peng,

Wang,

Zhang

et al. 2024

Preprint

View full text Add to dashboard Cite

Background Peri-operative pain neuroscience education(PNE) is emerging as a peri-operative pain-specific cognitive therapy. To optimize the efficacy of analgesia for patients receiving laparoscopic inguinal hernia repair, PNE was incorporated into multi-modal analgesia. Materials and methods A randomized controlled trial was conducted to compare conventionally peri-operative multi-modal analgesia (group CA) and the addition of pain neuroscience education into it (group PNE). Setting: this study was designed and conducted in a tertiary teaching hospital in Southwest China.patients receiving laparoscopic hernia repair. The peri-operative pain trajectory were investigated. Characteristics of peri-operative pain was evaluated with Douleur Neuropathique 4 questionnaire (DN−4), central sensitization inventory (CSI) and pain catastrophizing scale (PCS) post-operatively. Pressure pain threshold was also compared between two groups .Post-operative quality of recovery was measured with EuroQol five dimensions questionnaire (EQ-5D-5L).The incidence of chronic post-operative pain at 3 months after surgery was also recorded. Results A total of 184 patients consented to participate in this study and finished follow-up.Compared with those receiving conventional analgesia (group CA,N = 91), patients in group PNE (N = 93) reported reduced intensity of acute pain from 12 till 72 hours after surgery and less dosages of opioid during hospitalization (p < 0.05). Catastrophizing, sensitization of peri-operative pain were reduced in group PNE (p < 0.05). Quality of recovery was improved till one month after surgery(p < 0.05). Conclusions The addition of pain neuroscience education into peri-operative multi-modal analgesia improved analgesic effect and quality of recovery for patients undergoing laparoscopic inguinal hernia repair. This psychological analgesic regimen also helped reduce sensitization and catastrophizing of acute surgical pain in these patients.

show abstract

Effect of pain neuroscience education after breast cancer surgery on pain, physical, and emotional functioning: a double-blinded randomized controlled trial (EduCan trial)

Abstract: Supplemental Digital Content is Available in the Text.Adding 6 sessions of pain neuroscience education to standard physiotherapy after breast cancer surgery did not result in a better course of functioning compared with biomedical pain education.

Cited by 12 publications

References 64 publications

Effectiveness of pain neuroscience education on somatosensory functioning after surgery for breast cancer: A double‐blinded randomized controlled trial

Effectiveness of pain neuroscience education on somatosensory functioning after surgery for breast cancer: A double‐blinded randomized controlled trial

Effect of perceived injustice-targeted pain neuroscience education compared with biomedically focused education in breast cancer survivors: a study protocol for a multicentre randomised controlled trial (BCS-PI trial)

The effect of peri-operative pain neuroscience education on post-operative pain and recovery in adult patients receiving laparoscopic inguinal hernia repair---A prospective randomized controlled trial

Contact Info

Product

Resources

About