Effect of Oxymatrine Combined with Low Dose 5-FU on Lymphatic Vessel and Microvascular Endothelial Cell Growth of Gastric Cancer in a Severe Combined Immunodeficient Mouse Orthotopic Implantation Model

Js, Zhu; Zp, Xu; Song, Minju; Zhang, Q.

doi:10.1177/1721727x1100900107

Cited by 10 publications

(7 citation statements)

References 26 publications

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“… 36 We previously confirmed the inhibitory effects of OMT on vascular and lymph node invasion in GC. 37 Herein, we found that OMT displayed anti-tumor effects via regulation of JAK/STAT signaling pathway, suggesting the potential therapeutic target for treatment of GC.…”

Section: Introductionmentioning

confidence: 83%

“… 36 We have also reported that OMT combined with low-dose 5-fluorouracil (FU) or angiogenesis inhibitor NM-3 exhibits anti-tumor activity in GC cells. 37 , 44 Guo et al 45 have found that OMT inhibits the proliferation and invasion of GC cells via blockade of EGFR/AKT pathway. Here, we found that OMT exerted obvious anticancer effects on GC cells, which was related to inhibiting cell growth and invasion, arresting cell cycle, and inducing cell apoptosis, showing that OMT might be a novel candidate for adjuvant treatment of GC.…”

Section: Discussionmentioning

confidence: 99%

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Oxymatrine exhibits anti-tumor activity in gastric cancer through inhibition of IL-21R-mediated JAK2/STAT3 pathway

Huang

Zhang

Wang

et al. 2018

Int J Immunopathol Pharmacol

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Oxymatrine (OMT) as a type of alkaloids collected from Sophora flavescens Ait exerts some biological functions including anticancer properties. Here, we investigated the therapeutic effects of OMT in gastric cancer cells (HGC 27 and AGS). As a result, the exposure of gastric cancer (GC) cells to OMT contributed to the suppression of cell proliferation and invasion. Interleukin 21 receptor (IL-21R) was identified to be differentially expressed between OMT treatment group (4 mg/mL) and control group (0 mg/mL), and knockdown of IL-21R repressed cell proliferation and invasion via inactivation of the JAK2/STAT3 pathway. The rescue experiment showed that IL-21R overexpression attenuated the anti-tumor effects of OMT through activation of the JAK2/STAT3 pathway. Moreover, the expression of IL-21R was significantly upregulated in GC samples compared with the adjacent normal tissues and associated with overall survival (OS) and tumor recurrence of GC patients. Taken together, in this study, we evaluated the anti-tumor effects of OMT on GC by investigating proliferation and invasion ability changes, and our findings show that OMT exhibits effects via regulation of JAK/STAT signaling pathway. Through the mechanism study, we may enlighten the potential therapeutic target for treatment of GC.

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Section: Introductionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Oxymatrine exhibits anti-tumor activity in gastric cancer through inhibition of IL-21R-mediated JAK2/STAT3 pathway

Huang

Zhang

Wang

et al. 2018

Int J Immunopathol Pharmacol

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“…It is commonly known that oxymatrine exhibits many biological activities and possesses a wide range of pharmacological effects, such as anti-inflammation [ 16 ], antifibrosis [ 17 ], analgesic [ 18 ], immunosuppression [ 19 ], and antivirus [ 20 ]. Oxymatrine also has been extensively studied, for their cancer chemoprevention potentially against various cancers, for instance, gastric cancer [ 21 ], breast cancer [ 22 ], hepatocellular carcinoma [ 23 ], and pancreatic cancer [ 24 ]. However, the mechanisms of the antitumor properties of oxymatrine in laryngeal cancer are not well established to date.…”

Section: Discussionmentioning

confidence: 99%

Oxymatrine DownregulatesHPV16E7Expression and Inhibits Cell Proliferation in Laryngeal Squamous Cell Carcinoma Hep-2 Cells In Vitro

Ying

Jin

Chen

et al. 2015

BioMed Research International

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Objective. To investigate the possible mechanisms of oxymatrine's role in anti laryngeal squamous cell carcinoma. Methods. We examined the effects of oxymatrine on the proliferation, cell cycle phase distribution, apoptosis, and the protein and mRNA expression levels of HPV16E7 gene in laryngeal carcinoma Hep-2 cells in vitro. The HPV16E7 siRNA inhibition was also done to confirm the effect of downregulating HPV16E7 on the proliferation in Hep-2 cells. Results. Oxymatrine significantly inhibited the growth and proliferation of Hep-2 cells in a dose-dependence and time-dependence manner. Oxymatrine blocked Hep-2 cells in G0/G1 phase, resulting in an obvious accumulation of G0/G1 phase cells while decreasing S phase cells. Oxymatrine induced apoptosis of Hep-2 cells, whose apoptotic rate amounted to about 42% after treatment with 7 mg/mL oxymatrine for 72 h. Oxymatrine also downregulated the expression of HPV16E7 gene, as determined by the western blotting and reverse transcription-polymerase chain reaction analysis. Knockdown of HPV16E7 effectively inhibited the proliferation of Hep-2 cells. Conclusions. Oxymatrine inhibits the proliferation and induces apoptosis of laryngeal carcinoma Hep-2 cells, which might be mediated by a significant cell cycle arrest in G0/G1 phase and downregulation of HPV16E7 gene. Oxymatrine is considered to be a likely preventive and curative candidate for laryngeal cancer.

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“…IL-IFIO cDNA encodes 152-amino acid protein that shares between 41% and 43% amino acid identity with human IL-l receptor antagonist (IL-lRA). IL-IF 10 shares characteristics of the IL-l RA family, including key amino acid consensus sequences and a similar genomic structure (61)(62)(63)(64)(65). IL-IFIO mRNA is expressed in several tissue such as heart, placenta, fetal liver, spleen, thymus, and activated B cells of the human tonsil (66)(67)(68)(69)(70).…”

Section: Il-38 (Il-lflo)mentioning

confidence: 99%

IL-36 Receptor Antagonist with Special Emphasis on IL-38

Shaik

Sabatino

Maccauro

et al. 2013

Int J Immunopathol Pharmacol

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IL-36 is another family member of IL-1 and induces the production of proinflammatory cytokines and activates MAPK and NFκB pathways. IL-36 is a common mediator of innate and adaptive immune response and is inhibited by IL-36 receptor antagonist (RA). IL-36RA acts on IL-36 receptor ligand which exerts proinflammatory effect in vivo and in vitro. IL-38 binds to IL-36 receptor as does IL-36RA and has similar biological effects on immune cells. IL-38 is also a member of IL-1 cytokine and shares some characteristics of IL-1RA, binding the same IL-1 receptor type I. IL-38 plays a role in the pathogenesis of inflammatory diseases, exerting protective effect in some autoimmune diseases. Both IL-38 and IL-36RA have an anti-inflammatory biological effect, however in some cases have contrary effects.

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Effect of Oxymatrine Combined with Low Dose 5-FU on Lymphatic Vessel and Microvascular Endothelial Cell Growth of Gastric Cancer in a Severe Combined Immunodeficient Mouse Orthotopic Implantation Model

Cited by 10 publications

References 26 publications

Oxymatrine exhibits anti-tumor activity in gastric cancer through inhibition of IL-21R-mediated JAK2/STAT3 pathway

Oxymatrine exhibits anti-tumor activity in gastric cancer through inhibition of IL-21R-mediated JAK2/STAT3 pathway

Oxymatrine DownregulatesHPV16E7Expression and Inhibits Cell Proliferation in Laryngeal Squamous Cell Carcinoma Hep-2 Cells In Vitro

IL-36 Receptor Antagonist with Special Emphasis on IL-38

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