Effect of oxy-vanadium (IV) and oxy-zirconium (IV) ions in O,N-bidentate arylhydrazone complexes on their catalytic and biological potentials that supported via computerized usages

Mononucleating complexes of isatin hydrazone sodium sulfonate ligand (HLn) with palladium (II) and cobalt (II) ions: The complexes were synthesized within 1:1 and 2:1 molar ratio of HLn with Pd 2+ and Co 2+ ion in PdLn and Co (Ln) 2 , respectively. The catalytic reactivity of both complexes was examined in the oxidation of sulfides (diphenyl sulfide, dps, and methylphenyl sulfide, mps) using hydrogen peroxide under aerobic conditions. Oxoproducts, dipheylsufoxide, dpo, and methyl phenyl sulfoxide, mpo, are the chemoselective products with detection of large amounts of the unselective further oxidation products of dioxoproducts (dipheylsufone, dpn, and methylphenyl sulfone, mpn). The homogenous catalyst of Co (Ln) 2 revealed more efficient action compared to that of PdLn depending on the high electrochemical reversible potential of the central metal ion in the catalytic reaction within the electron and/or oxygen transfer system. Exploring the importance of the M 2+ ion in the coordinated ligand, the bioreactivity of HLn, PdLn, and Co (Ln) 2 was illustrated within some commonly well-known bacteria and fungi strains. Additionally, they were involved as anticancer reagents against some human cancer cell lines in vitro. Both metal complexes presented high inhibited action versus the growth of the studied microorganism and cancer. The interaction effect of Pd 2+ and Co 2+ ions in their pincer complexes was tested with calf thymus DNA spectroscopically and via the viscosity changes.

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“…From Equation 2, A was the pre-exponential factor, and R was the gas constant. [37] 2.5 | Biological assays…”

Section: Kinetics Of the Catalytic Oxidation Of Sulfidesmentioning

confidence: 99%

Promoted catalytic potential in sulfides oxidation and biological screening of green Pd (II) and Co (II) complexes of salicylidene isatin hydrazone ligand

Adam

Makhlouf

Mohamed

et al. 2022

Applied Organom Chemis

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“…The activity index [ 18 , 19 , 20 , 21 , 22 , 23 ] of Na abietate for each evaluated bacterial strain was estimated by the ratio between the inhibition zones of the tested compound and of the standard antimicrobial. Promising results were obtained, especially against the S. enterica Typhimurium strain, with an activity index of 1.17 ( Figure 6 d).…”

Section: Resultsmentioning

confidence: 99%

“…The activity index ( A.I ) was also calculated according to Equation (1) [ 18 , 19 , 20 , 21 , 22 , 23 ].

…”

Section: Methodsmentioning

confidence: 99%

Green Synthesis of Na abietate Obtained from the Salification of Pinus elliottii Resin with Promising Antimicrobial Action

et al. 2023

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The growing concern about the emergence of increasingly antibiotic-r4esistant bacteria imposes the need to search and develop drugs to combat these microorganisms. This, combined with the search for low-cost synthesis methods, was the motivation for the elaboration of this work. Abietic acid present in the resin of Pinus elliotti var. elliotti was used to generate a sodium salt by salification. The synthesis route was low-cost, consisting of only two reaction steps at mild temperatures without toxic organic solvents, and eco-friendly and easy to conduct on an industrial scale. Sodium abietate (Na-C20H29O2) was characterized by mass spectrometry, infrared spectroscopy, elemental analysis, X-ray diffraction, scanning electron microscopy, and energy-dispersive spectroscopy. To perform the antimicrobial tests, the determination of minimum inhibitory concentration and the disk diffusion assay was performed. The results obtained showed that the salt Na abietate performed an antimicrobial action against the bacterial strains S. aureus, E. coli, L.monocytogenes, and S. enterica Typhimurium and the yeast C. albicans. The disk diffusion test showed a high inhibition potential against S. enterica compared to the standard antimicrobial tetracycline, as an inhibition index of 1.17 was found. For the other bacterial strains, the inhibition values were above 40%. The MIC test showed promising results in the inhibition of E. coli, L. monocytogenes, and C. albicans, indicating bacteriostatic activity against the first microorganism and bactericidal and fungicidal activities against the others. Therefore, the results showed the action of Na abietate as a possible effective antimicrobial drug, highlighting its sustainability within a circular economy.

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“…The literature presents very good results regarding the diffusion disk method applied to vanadium complexes [ 14 , 25 , 26 , 29 ]. One of the works reports a zone of inhibition of 10.4 to 12.6 mm for E. coli and 10.8 to 21.6 mm for S.aureus for vanadium complexes synthesized with ligands derived from thiourea [ 25 ].…”

Section: Resultsmentioning

confidence: 99%

Eco-Friendly Synthesis of an Oxovanadium(IV)-bis(abietate) Complex with Antimicrobial Action

et al. 2022

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The search for less expensive and viable products is always one of the challenges for research development. Commonly, the synthesis of coordination compounds involves expensive ligands, through expensive and low-yield routes, in addition to generating toxic and unusable residues. In this work, the organic ligand used is derived from the resin of a reforestation tree, Pinus elliottii var. elliottii. The synthesis method used Pinus resin and an aqueous solution of vanadium(III) chloride at a temperature of 80 °C. The procedure does not involve organic solvents and does not generate toxic residues, thus imparting the complex formation reaction a green chemistry character. The synthesis resulted in an unprecedented oxovanadium(IV)-bis(abietate) complex, which was characterized by mass spectrometry (MS), chemical analysis (CHN), vibrational (FTIR) and electronic spectra (VISIBLE), X-ray diffraction (XRD), and thermal analysis (TG/DTA). Colorimetric studies were performed according to the CIELAB color space. The structural formula found, consisted of a complex containing two abietate ligands, [VO(C20H29O2)2]. The VO(IV)-bis(abietate) complex was applied against microorganisms and showed promising results in antibacterial and antifungal activity. The best result of inhibitory action was against the strains of Gram-positive bacteria S. aureus and L. monocytogenes, with minimum inhibitory concentration (MIC) values of 62.5 and 125 μmol L−1, respectively. For Gram-negative strains the results were 500 μmol L−1 for E. coli; and 1000 μmol L−1 for Salmonella enterica Typhimurium. Antifungal activity was performed against Candida albicans, where the MIC was 15.62 μmol L−1, and for C. tropicalis it was 62.5 μmol L−1. According to the MFC analysis, the complex presented, in addition to the fungistatic action, a fungicidal action, as there was no growth of fungi on the plates tested. The results found for the tests demonstrate that the VO(IV)-bis(abietate) complex has great potential as an antimicrobial and mainly antifungal agent. In this way, the pigmented ink with antimicrobial activity could be used in environments with a potential risk of contamination, preventing the spread of microorganisms harmful to health.

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Effect of oxy-vanadium (IV) and oxy-zirconium (IV) ions in O,N-bidentate arylhydrazone complexes on their catalytic and biological potentials that supported via computerized usages

Cited by 20 publications

References 96 publications

Promoted catalytic potential in sulfides oxidation and biological screening of green Pd (II) and Co (II) complexes of salicylidene isatin hydrazone ligand

Promoted catalytic potential in sulfides oxidation and biological screening of green Pd (II) and Co (II) complexes of salicylidene isatin hydrazone ligand

Green Synthesis of Na abietate Obtained from the Salification of Pinus elliottii Resin with Promising Antimicrobial Action

Eco-Friendly Synthesis of an Oxovanadium(IV)-bis(abietate) Complex with Antimicrobial Action

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